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Peer-reviewedCC BYPLOS Computational Biology

Ten simple rules to build genomics capacity for routine laboratory practice in the Global South

  • Emilyn Costa Conceição1
  • Abhinav Sharma2
  • Davi Josué Marcon3
  • Layana Rufino Ribeiro4
  • Danna Karen Corrêa dos Santos5
  • Lilian Eduarda de Oliveira Freitas6
  • Alex Brito Souza7
  • Hendor Neves Ribeiro de Jesus8
  • Maria Cristina da Silva Lourenço9
  • Valnete das Graças Dantas Andrade10
  • Marco Aurélio Almeida de Oliveira11
  • Tatyana Costa Amorim Ramos12
11 more authors
  • Ítalo José Mesquita Cavalcante13
  • Arabela Leal e Silva de Melo14
  • Nabila Ismail
  • Tulio de Oliveira
  • Robin Mark Warren
  • Adriana Ayden Ferreira
  • Theolis Costa Barbosa Bessa
  • Cristiane Cunha Frota
  • Philip Noel Suffys
  • Karla Valéria Batista Lima
  • REVIGET Consortium
14 affiliations
  1. 1South African Medical Research Council Centre for Tuberculosis Research (SAMRC), Division of Molecular Biology and Human Genetics (MBHG), Biomedical Research Institute (BMRI), Faculty of Medicine and Health Sciences (FMHS), Stellenbosch University, Cape Town, South Africa
  2. 2Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa
  3. 3Rede Brasileira de Pesquisas em Tuberculose (REDE-TB), Rio de Janeiro, Rio de Janeiro, Brazil
  4. 4Programa de Pós-graduação em Biologia Parasitária na Amazônia (PPG-BPA), Universidade do Estado do Pará (UEPA), Belém, Pará, Brazil
  5. 5Seção de Bacteriologia e Micologia (SABMI), Instituto Evandro Chagas (IEC), Ananindeua, Pará, Brazil
  6. 6Programa de Pós-graduação em Epidemiologia e Vigilância em Saúde (PPGEVS), Instituto Evandro Chagas (IEC), Ananindeua, Pará, Brazil
  7. 7Laboratório Central do Amazonas (LACEN-AM), Fundação de Vigilância em Saúde do Amazonas Dra. Rosemary Costa Pinto (FVS-RCP), Manaus, Amazonas, Brazil
  8. 8Instituto Gonçalo Moniz (IMG), Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Bahia, Brazil
  9. 9Laboratório de Bacteriologia e Bioensaios em Micobactérias, Instituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil
  10. 10Laboratório Central do Pará (LACEN-PA), Belém, Pará, Brazil
  11. 11Laboratório Central do Ceará (LACEN-CE), Fortaleza, Ceará, Brazil
  12. 12Laboratório Central da Bahia (LACEN-BA), Salvador, Bahia, Brazil
  13. 13Programa de Pós-graduação em Patologia, Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil
  14. 14Laboratório de Biologia Molecular Aplicada a Micobacterias, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil
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Abstract

Developing sustainable genomics capacity in the Global South requires more than technology transfer; it depends on human-centered approaches based on the workflows and existing expertise of laboratory personnel, institutional collaboration, and long-term integration into health systems. Drawing on lessons learned from regional capacity-building initiatives, this article proposes ten simple rules for implementing and sustaining genomics capacity within public health and clinical laboratory settings. These rules emphasize local context, strategic planning, continuous learning, and equitable collaboration. Together, they provide a roadmap for laboratories aiming to transform genomic technologies from research tools for diagnosis, surveillance and decision-making, into routine instruments for public health in low- and middle-income countries.

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Cite

BibTeXRIS
BibTeX
@article{conceicao2026simple,
  title = {{Ten simple rules to build genomics capacity for routine laboratory practice in the Global South}},
  author = {Emilyn Costa Conceição and Abhinav Sharma and Davi Josué Marcon and Layana Rufino Ribeiro and Danna Karen Corrêa dos Santos and Lilian Eduarda de Oliveira Freitas and Alex Brito Souza and Hendor Neves Ribeiro de Jesus and Maria Cristina da Silva Lourenço and Valnete das Graças Dantas Andrade and Marco Aurélio Almeida de Oliveira and Tatyana Costa Amorim Ramos and Ítalo José Mesquita Cavalcante and Arabela Leal e Silva de Melo and Nabila Ismail and Tulio de Oliveira and Robin Mark Warren and Adriana Ayden Ferreira and Theolis Costa Barbosa Bessa and Cristiane Cunha Frota and Philip Noel Suffys and Karla Valéria Batista Lima and REVIGET Consortium},
  journal = {PLOS Computational Biology},
  year = {2026},
  month = oct,
  doi = {10.1371/journal.pcbi.1014863},
  url = {https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1014863},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Ten simple rules to build genomics capacity for routine laboratory practice in the Global South
AU  - Emilyn Costa Conceição
AU  - Abhinav Sharma
AU  - Davi Josué Marcon
AU  - Layana Rufino Ribeiro
AU  - Danna Karen Corrêa dos Santos
AU  - Lilian Eduarda de Oliveira Freitas
AU  - Alex Brito Souza
AU  - Hendor Neves Ribeiro de Jesus
AU  - Maria Cristina da Silva Lourenço
AU  - Valnete das Graças Dantas Andrade
AU  - Marco Aurélio Almeida de Oliveira
AU  - Tatyana Costa Amorim Ramos
AU  - Ítalo José Mesquita Cavalcante
AU  - Arabela Leal e Silva de Melo
AU  - Nabila Ismail
AU  - Tulio de Oliveira
AU  - Robin Mark Warren
AU  - Adriana Ayden Ferreira
AU  - Theolis Costa Barbosa Bessa
AU  - Cristiane Cunha Frota
AU  - Philip Noel Suffys
AU  - Karla Valéria Batista Lima
AU  - REVIGET Consortium
PY  - 2026
DA  - 2026/10/01
JO  - PLOS Computational Biology
DO  - 10.1371/journal.pcbi.1014863
UR  - https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1014863
AB  - Developing sustainable genomics capacity in the Global South requires more than technology transfer; it depends on human-centered approaches based on the workflows and existing expertise of laboratory personnel, institutional collaboration, and long-term integration into health systems. Drawing on lessons learned from regional capacity-building initiatives, this article proposes ten simple rules for implementing and sustaining genomics capacity within public health and clinical laboratory settings. These rules emphasize local context, strategic planning, continuous learning, and equitable collaboration. Together, they provide a roadmap for laboratories aiming to transform genomic technologies from research tools for diagnosis, surveillance and decision-making, into routine instruments for public health in low- and middle-income countries.
SN  - 1553-7358
SN  - 1553-734X
ER  -