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Peer-reviewedCC BY 4.0Frontiers in Microbiology

Multi-omics analysis reveals the anti-hyperlipidemic mechanism of 1,8-cineole from Camphora longepaniculata essential oil via gut microbiota and lipid metabolism modulation

  • Guohui Nan
  • Jingyi Yang
  • Hongxian Chen
  • Walid Tahri
  • Zhiping Fan
  • Juanjuan Zhang
  • Jie Yuan
  • Tingna Xie
  • Shiyin Jiang
  • Qin Wei
  • Shuang Yang
  • Lisong Liu
1 more authors
  • Qi Wu
Open at sourceDOICite

Abstract

BackgroundHigh-fat diet-induced hyperlipidemia exerts prominent impacts on human health and economic development. 1,8-cineole (CIN), the major component of Camphora longepaniculata essential oil, possesses bioactive properties. However, the lipid-lowering efficacy and molecular mechanisms of CIN remain insufficiently and systematically investigated.MethodsThis study assessed the effects of CIN on physiological indices and serum biochemical parameters in high-fat diet-fed mice. Metagenomic sequencing, transcriptomics, and untargeted metabolomics were further adopted to analyze CIN-induced changes in gut microbiota composition, hepatic gene expression, and serum metabolite profiles.ResultsThe results showed that CIN significantly decreased serum TG and LDL-C while increasing the level of HDL-C. In addition, CIN treatment was associated with a reduced Bacillota/Bacteroidota ratio, a restoration of the HFD-induced Bacteroidota shift and a modulation of Bacteroides at the genus and species level, modulation of hepatic expression of Fasn, Hmgcs1, Cyp4a14, and Acot1, and remodeling of serum metabolites involved in glycerophospholipid and linoleic acid metabolism.ConclusionThis study provides novel insights into the treatment of hyperlipidemia and validates the potential development of CIN as a functional food component.

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Cite

BibTeXRIS
BibTeX
@article{nan2026multiomics,
  title = {{Multi-omics analysis reveals the anti-hyperlipidemic mechanism of 1,8-cineole from Camphora longepaniculata essential oil via gut microbiota and lipid metabolism modulation}},
  author = {Guohui Nan and Jingyi Yang and Hongxian Chen and Walid Tahri and Zhiping Fan and Juanjuan Zhang and Jie Yuan and Tingna Xie and Shiyin Jiang and Qin Wei and Shuang Yang and Lisong Liu and Qi Wu},
  journal = {Frontiers in Microbiology},
  year = {2026},
  month = nov,
  doi = {10.3389/fmicb.2026.1920512},
  url = {https://www.frontiersin.org/articles/10.3389/fmicb.2026.1920512},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Multi-omics analysis reveals the anti-hyperlipidemic mechanism of 1,8-cineole from Camphora longepaniculata essential oil via gut microbiota and lipid metabolism modulation
AU  - Guohui Nan
AU  - Jingyi Yang
AU  - Hongxian Chen
AU  - Walid Tahri
AU  - Zhiping Fan
AU  - Juanjuan Zhang
AU  - Jie Yuan
AU  - Tingna Xie
AU  - Shiyin Jiang
AU  - Qin Wei
AU  - Shuang Yang
AU  - Lisong Liu
AU  - Qi Wu
PY  - 2026
DA  - 2026/11/04
JO  - Frontiers in Microbiology
DO  - 10.3389/fmicb.2026.1920512
UR  - https://www.frontiersin.org/articles/10.3389/fmicb.2026.1920512
AB  - BackgroundHigh-fat diet-induced hyperlipidemia exerts prominent impacts on human health and economic development. 1,8-cineole (CIN), the major component of Camphora longepaniculata essential oil, possesses bioactive properties. However, the lipid-lowering efficacy and molecular mechanisms of CIN remain insufficiently and systematically investigated.MethodsThis study assessed the effects of CIN on physiological indices and serum biochemical parameters in high-fat diet-fed mice. Metagenomic sequencing, transcriptomics, and untargeted metabolomics were further adopted to analyze CIN-induced changes in gut microbiota composition, hepatic gene expression, and serum metabolite profiles.ResultsThe results showed that CIN significantly decreased serum TG and LDL-C while increasing the level of HDL-C. In addition, CIN treatment was associated with a reduced Bacillota/Bacteroidota ratio, a restoration of the HFD-induced Bacteroidota shift and a modulation of Bacteroides at the genus and species level, modulation of hepatic expression of Fasn, Hmgcs1, Cyp4a14, and Acot1, and remodeling of serum metabolites involved in glycerophospholipid and linoleic acid metabolism.ConclusionThis study provides novel insights into the treatment of hyperlipidemia and validates the potential development of CIN as a functional food component.
SN  - 1664-302X
ER  -