Associations Between Cereal-Based Food Consumption and Urinary Mycotoxin Biomarkers in a Hungarian Population.
8 affiliations
- 1HUN-REN-MATE, Mycotoxins in the Food Chain Research Group, Science, Guba S. Str. 40, 7400 Kaposvár, Hungary.
- 2MATE Doctoral School of Agricultural and Food Sciences, Guba S. Str. 40, 7400 Kaposvár, Hungary.
- 3Institute of Animal Sciences, Kaposvár Campus, Hungarian University of Agricultural and Life Sciences, Guba S. Str. 40, 7400 Kaposvár, Hungary.
- 4Institute of Sciences of Food Production (ISPA), National Research Council (CNR), 70126 Bari, Italy.
- 5Department of Dietetics and Nutritional Sciences, Faculty of Health Sciences, Semmelweis University, 1088 Budapest, Hungary.
- 6NutriComp Ltd., Üllői Street 179, 1091 Budapest, Hungary.
- 7Department of Digital Food Science, Institute of Food Chain Science, University of Veterinary Medicine Budapest, István Street 2, 1078 Budapest, Hungary.
- 8Agro-Biotechnology and Precision Breeding for Food Security National Laboratory, Institute of Physiology and Nutrition, Kaposvár Campus, Hungarian University of Agricultural and Life Sciences, Guba S. Str. 40, 7400 Kaposvár, Hungary.
Abstract
Mycotoxins are common contaminants of the food and feed chain and have been associated with developmental disorders, hepatotoxicity, nephrotoxicity, and various types of cancer. This study aimed to estimate dietary mycotoxin exposure in the Hungarian population and to identify the major cereal-based food contributors. Urinary mycotoxin concentrations were measured by LC-MS/MS, and population exposure was assessed using estimated daily intake (EDI) values. Associations between food consumption and urinary mycotoxin levels were evaluated using Spearman correlation analysis on urine samples collected in year 2018 and 2020. The average EDI values were below the tolerable daily intake (TDI) for all mycotoxins in both years, except for ochratoxin A in 2018. Distinct exposure patterns were observed between the two sampling years. In 2018, consumption of oats and oat-based products showed a moderate positive correlation with urinary fumonisin B₂ levels (r(s) = 0.497, adjusted p = 0.001962350574942). In 2020, wheat and wheat-based product consumption correlated with urinary deoxynivalenol levels (r(s) = 0.6868, adjusted p = 0.009509496), while corn and corn-based product consumption correlated with urinary zearalenone levels (r(s) = 0.6137, adjusted p = 0.04134226737). These findings highlight differences in dietary mycotoxin exposure between the studied populations and sampling periods and emphasize the importance of human biomonitoring to identify major dietary mycotoxin sources/carriers and support exposure and risk assessment.
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BibTeX
@article{schieszl2026associations,
title = {{Associations Between Cereal-Based Food Consumption and Urinary Mycotoxin Biomarkers in a Hungarian Population.}},
author = {Tamás Schieszl and György Kövér and Lucia Gambacorta and Michele Solfrizzo and Lajos Biró and Györgyi Arató and Andrea Zentai and Brigitta Bóta and András Szabó and Melinda Kovács},
journal = {Toxins},
year = {2026},
month = oct,
doi = {10.3390/toxins18100436},
url = {https://europepmc.org/article/MED/42931527},
note = {CC BY},
}
RIS
TY - JOUR
TI - Associations Between Cereal-Based Food Consumption and Urinary Mycotoxin Biomarkers in a Hungarian Population.
AU - Tamás Schieszl
AU - György Kövér
AU - Lucia Gambacorta
AU - Michele Solfrizzo
AU - Lajos Biró
AU - Györgyi Arató
AU - Andrea Zentai
AU - Brigitta Bóta
AU - András Szabó
AU - Melinda Kovács
PY - 2026
DA - 2026/10/10
JO - Toxins
DO - 10.3390/toxins18100436
UR - https://europepmc.org/article/MED/42931527
AB - Mycotoxins are common contaminants of the food and feed chain and have been associated with developmental disorders, hepatotoxicity, nephrotoxicity, and various types of cancer. This study aimed to estimate dietary mycotoxin exposure in the Hungarian population and to identify the major cereal-based food contributors. Urinary mycotoxin concentrations were measured by LC-MS/MS, and population exposure was assessed using estimated daily intake (EDI) values. Associations between food consumption and urinary mycotoxin levels were evaluated using Spearman correlation analysis on urine samples collected in year 2018 and 2020. The average EDI values were below the tolerable daily intake (TDI) for all mycotoxins in both years, except for ochratoxin A in 2018. Distinct exposure patterns were observed between the two sampling years. In 2018, consumption of oats and oat-based products showed a moderate positive correlation with urinary fumonisin B₂ levels (r(s) = 0.497, adjusted p = 0.001962350574942). In 2020, wheat and wheat-based product consumption correlated with urinary deoxynivalenol levels (r(s) = 0.6868, adjusted p = 0.009509496), while corn and corn-based product consumption correlated with urinary zearalenone levels (r(s) = 0.6137, adjusted p = 0.04134226737). These findings highlight differences in dietary mycotoxin exposure between the studied populations and sampling periods and emphasize the importance of human biomonitoring to identify major dietary mycotoxin sources/carriers and support exposure and risk assessment.
SN - 2072-6651
ER -