Mortality trends of aspiration-associated respiratory failure in the united states : a multiple cause of death analysis.
8 affiliations
- 1Dow University of Health Sciences, Karachi, Pakistan.
- 2Faculty of Medicine, Kandahar University, District # 10, Kandahar, 3801, Afghanistan. [email protected].
- 3Bahria University College of Medicine, Bahria University, Islamabad, Pakistan.
- 4University of Medical Sciences and Technology, Khartoum, Sudan.
- 5Jinnah Sindh Medical University, Karachi, Pakistan.
- 6Department of Medicine, Howard University Hospital, Washington, DC, USA.
- 7Khyber Medical University, Peshawar, Khyber Pakhtunkhwa, Pakistan.
- 8Shaheed Mohtarma Benazir Bhutto Medical College, Lyari, Karachi, Pakistan.
Abstract
Background
Aspiration-associated respiratory failure is an important but under-recognized cause of morbidity and mortality among U.S. adults. Despite its clinical significance, national epidemiologic patterns and demographic disparities remain poorly characterized.Methods
Mortality data from the CDC WONDER Database (1999-2023) were extracted for adults aged ≥ 25 years in the U.S. with Aspiration and Respiratory Failure listed as underlying or contributing causes of death. Age-adjusted mortality rates (AAMRs) were calculated. Joinpoint regression was used to estimate the Annual Percent Change (APC) and Annual Average Percentage Change (AAPC) with 95% confidence intervals (CIs).Results
Between 1999 and 2023, 372,764 deaths involving aspiration-associated respiratory failure were identified among U.S. adults aged ≥ 25 years. The age-adjusted mortality rate increased from 4.27 to 10.17 per 100,000 population (AAPC: 3.98%; p < 0.001). Males had higher mean AAMRs than females (8.94 vs. 4.72 per 100,000). Adults aged ≥ 65 years had the highest crude mortality rate (27.79 per 100,000). Non-Hispanic African Americans (7.10) and American Indian/Alaska Native populations (6.61) had the highest mean AAMRs, while metropolitan areas had slightly higher AAMRs than non-metropolitan areas (5.99 vs. 5.40).Conclusion
Mortality involving aspiration-associated respiratory failure increased significantly from 1999 to 2023, with substantial demographic and geographic disparities. These findings support improved dysphagia prevention, surveillance, and targeted public health interventions.
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BibTeX
@article{alam2026mortality,
title = {{Mortality trends of aspiration-associated respiratory failure in the united states : a multiple cause of death analysis.}},
author = {Taha Alam and Ehsanullah Alokozay and Sohaima Kamal and Fnu Areesha and Muhammad Ibrahim Rashid and Iman Osman Abufatima and Noor Un Nisa and Muhammad Junaid Azhar and Amber Alam and Ali Chand and Nafila Zeeshan and Mahwish Gulbahar and Alem Mehari},
journal = {BMC public health},
year = {2026},
month = aug,
doi = {10.1186/s12889-026-28885-x},
url = {https://europepmc.org/article/MED/42958142},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Mortality trends of aspiration-associated respiratory failure in the united states : a multiple cause of death analysis.
AU - Taha Alam
AU - Ehsanullah Alokozay
AU - Sohaima Kamal
AU - Fnu Areesha
AU - Muhammad Ibrahim Rashid
AU - Iman Osman Abufatima
AU - Noor Un Nisa
AU - Muhammad Junaid Azhar
AU - Amber Alam
AU - Ali Chand
AU - Nafila Zeeshan
AU - Mahwish Gulbahar
AU - Alem Mehari
PY - 2026
DA - 2026/08/04
JO - BMC public health
DO - 10.1186/s12889-026-28885-x
UR - https://europepmc.org/article/MED/42958142
AB - Background Aspiration-associated respiratory failure is an important but under-recognized cause of morbidity and mortality among U.S. adults. Despite its clinical significance, national epidemiologic patterns and demographic disparities remain poorly characterized.Methods Mortality data from the CDC WONDER Database (1999-2023) were extracted for adults aged ≥ 25 years in the U.S. with Aspiration and Respiratory Failure listed as underlying or contributing causes of death. Age-adjusted mortality rates (AAMRs) were calculated. Joinpoint regression was used to estimate the Annual Percent Change (APC) and Annual Average Percentage Change (AAPC) with 95% confidence intervals (CIs).Results Between 1999 and 2023, 372,764 deaths involving aspiration-associated respiratory failure were identified among U.S. adults aged ≥ 25 years. The age-adjusted mortality rate increased from 4.27 to 10.17 per 100,000 population (AAPC: 3.98%; p < 0.001). Males had higher mean AAMRs than females (8.94 vs. 4.72 per 100,000). Adults aged ≥ 65 years had the highest crude mortality rate (27.79 per 100,000). Non-Hispanic African Americans (7.10) and American Indian/Alaska Native populations (6.61) had the highest mean AAMRs, while metropolitan areas had slightly higher AAMRs than non-metropolitan areas (5.99 vs. 5.40).Conclusion Mortality involving aspiration-associated respiratory failure increased significantly from 1999 to 2023, with substantial demographic and geographic disparities. These findings support improved dysphagia prevention, surveillance, and targeted public health interventions.
SN - 1471-2458
ER -