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Peer-reviewedCC BY-NC 3.0RSC Advances

Ethyl gallate as an unexplored organocatalyst: unlocking sustainable routes to isoxazolones

  • Saptadwipa Bhattacharjee1
  • Puja Basak1
  • Pranab Ghosh1
  1. 1Department of Chemistry, University of North Bengal Dist-Darjeeling West Bengal India +91-(0353)-2699001 +91-(0353)-2776381
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Abstract

A simple and effective approach has been established for producing a wide range of pharmaceutically valuable functionalised 3-methyl-4-(hetero)arylmethylene isoxazole-5(4H)-ones. In this method, ethyl gallate (EG) was identified as a previously unexplored and potent organocatalyst, allowing for quick one-pot conversion to isoxazolones. The technique offers several major benefits, including metal-free conditions, good to exceptional yields, the use of readily available starting materials, and overall operational simplicity.

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Cite

BibTeXRIS
BibTeX
@article{bhattacharjee2026ethyl,
  title = {{Ethyl gallate as an unexplored organocatalyst: unlocking sustainable routes to isoxazolones}},
  author = {Saptadwipa Bhattacharjee and Puja Basak and Pranab Ghosh},
  journal = {RSC Advances},
  year = {2026},
  month = aug,
  doi = {10.1039/d6ra05201k},
  url = {https://doi.org/10.1039/d6ra05201k},
  note = {CC BY-NC 3.0},
}
RIS
TY  - JOUR
TI  - Ethyl gallate as an unexplored organocatalyst: unlocking sustainable routes to isoxazolones
AU  - Saptadwipa Bhattacharjee
AU  - Puja Basak
AU  - Pranab Ghosh
PY  - 2026
DA  - 2026/08/24
JO  - RSC Advances
DO  - 10.1039/d6ra05201k
UR  - https://doi.org/10.1039/d6ra05201k
AB  - A simple and effective approach has been established for producing a wide range of pharmaceutically valuable functionalised 3-methyl-4-(hetero)arylmethylene isoxazole-5(4H)-ones. In this method, ethyl gallate (EG) was identified as a previously unexplored and potent organocatalyst, allowing for quick one-pot conversion to isoxazolones. The technique offers several major benefits, including metal-free conditions, good to exceptional yields, the use of readily available starting materials, and overall operational simplicity.
SN  - 2046-2069
ER  -