Changes in the Quantitative Computed Tomography Values in Drug-associated Interstitial Lung Disease Caused by Non-anticancer Drugs
Abstract
Objective A quantitative computed tomography (QCT) analysis based on whole-lung density (WLD) histograms helps monitor the state of interstitial lung disease. We investigated the changes in QCT metrics in patients with drug-associated interstitial lung disease (DILD) and their correlation with inflammatory markers. Methods A QCT analysis using a 3D Slicer software program based on a WLD histogram was performed, excluding patients treated with anticancer agents or those undergoing treatment for malignant tumors to eliminate the effect of tumor size on QCT values. We evaluated the percentages of high attenuation areas (HAA%) at -700 Hounsfield Units (HU) (HAA%-700), -600 HU (HAA%-600), and from -600 to -250 HU [HAA%-(600-250)].Materials We analyzed patients diagnosed with DILD at our hospital between July 2013 and October 2024. Results The HAA%-700, HAA%-600, and HAA%-(600-250) values were significantly higher at diagnosis compared to the post-treatment values (28.14±13.60% versus 15.64±9.70%, p=0.0002; 18.45±10.40% versus 9.88±6.26%, p=0.0002; and 14.00±8.14% versus 7.65±4.72%, p=0.0002, respectively). The steroid-treated group had higher inflammatory marker levels than the non-steroid-treated group at the time of diagnosis. The HAA%-600 was significantly higher in the steroid-treated group than that in the non-steroid-treated group (21.42±12.35% vs. 13.18±4.31%, p=0.0128). The HAA%-700, HAA%-600, and HAA%-(600-250) values correlated with the inflammatory marker values. Conclusion The HAA% values in patients with DILD were significantly higher at diagnosis than after treatment and they also correlated with the inflammatory marker values.
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BibTeX
@article{itano2026changes,
title = {{Changes in the Quantitative Computed Tomography Values in Drug-associated Interstitial Lung Disease Caused by Non-anticancer Drugs}},
author = {Junko Itano and Hisao Higo and Goro Kimura and Megumi Takemoto and Noriko Hayashibara and Yasushi Tanimoto},
journal = {Internal Medicine},
year = {2026},
month = aug,
doi = {10.2169/internalmedicine.6510-25},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_6510-25/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Changes in the Quantitative Computed Tomography Values in Drug-associated Interstitial Lung Disease Caused by Non-anticancer Drugs
AU - Junko Itano
AU - Hisao Higo
AU - Goro Kimura
AU - Megumi Takemoto
AU - Noriko Hayashibara
AU - Yasushi Tanimoto
PY - 2026
DA - 2026/08/01
JO - Internal Medicine
DO - 10.2169/internalmedicine.6510-25
UR - https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_6510-25/_article
AB - Objective A quantitative computed tomography (QCT) analysis based on whole-lung density (WLD) histograms helps monitor the state of interstitial lung disease. We investigated the changes in QCT metrics in patients with drug-associated interstitial lung disease (DILD) and their correlation with inflammatory markers. Methods A QCT analysis using a 3D Slicer software program based on a WLD histogram was performed, excluding patients treated with anticancer agents or those undergoing treatment for malignant tumors to eliminate the effect of tumor size on QCT values. We evaluated the percentages of high attenuation areas (HAA%) at -700 Hounsfield Units (HU) (HAA%-700), -600 HU (HAA%-600), and from -600 to -250 HU [HAA%-(600-250)].Materials We analyzed patients diagnosed with DILD at our hospital between July 2013 and October 2024. Results The HAA%-700, HAA%-600, and HAA%-(600-250) values were significantly higher at diagnosis compared to the post-treatment values (28.14±13.60% versus 15.64±9.70%, p=0.0002; 18.45±10.40% versus 9.88±6.26%, p=0.0002; and 14.00±8.14% versus 7.65±4.72%, p=0.0002, respectively). The steroid-treated group had higher inflammatory marker levels than the non-steroid-treated group at the time of diagnosis. The HAA%-600 was significantly higher in the steroid-treated group than that in the non-steroid-treated group (21.42±12.35% vs. 13.18±4.31%, p=0.0128). The HAA%-700, HAA%-600, and HAA%-(600-250) values correlated with the inflammatory marker values. Conclusion The HAA% values in patients with DILD were significantly higher at diagnosis than after treatment and they also correlated with the inflammatory marker values.
SN - 1349-7235
SN - 0918-2918
ER -