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Peer-reviewedCC BY-NC-NDAmerican Heart Journal Plus

Rationale and design of RECOVER – a prospective, longitudinal cardiac rehabilitation registry

  • Jan Riess1
  • Elisa Alba Schmidt2
  • Gloria Petrasch2
  • Hadassa Brito Da Silva2
  • Sarah Sichler2
  • Pietro Sartori3
  • Eleonora Di Carluccio3
  • Cornelia Haberfellner2
  • Juliana Senftinger1
  • Miriam Albus2
  • Kathrin Bieri2
  • Claudio Rhyner4
31 more authors
  • Greta Hametner2
  • Luisa M. Prechtl2
  • Meike Distler2
  • Lena Jellestad5
  • Flavio D'Ascenzi6
  • Milena Sokolowska7
  • Hector Rodriguez Cetina Biefer8
  • Omer Dzemali8
  • Roger Von Moos9
  • Raphael Twerenbold10
  • Martin Loidl11
  • Felix C. Tanner12
  • Caroline Lustenberger13
  • Thijs M.H. Eijsvogels14
  • Esmée A. Bakker15
  • Corey R. Tomczak16
  • Aaron Baggish17
  • Simon Kraler18
  • Elmar Aigner19
  • Alex W. Carter20
  • Nicole Bauer21
  • Martin Röösli22
  • Imad El Haddad23
  • Daniel Häuptli2
  • Tsogyal D. Latshang2
  • Jan Steffel24
  • Mark J. Haykowsky25
  • Stefan Blankenberg26
  • Jan Vontobel2
  • Andreas Ziegler
  • David Niederseer
26 affiliations
  1. 1Hochgebirgsklinik, Medicine Campus Davos, Davos, Switzerland; Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  2. 2Hochgebirgsklinik, Medicine Campus Davos, Davos, Switzerland
  3. 3Cardio-CARE, Medicine Campus Davos, Davos, Switzerland
  4. 4Christine Kühne-Center for Allergy Research and Education (CK-CARE), Medicine Campus Davos, Davos, Switzerland; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
  5. 5Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, Zurich, Switzerland
  6. 6Department of Medical Biotechnologies, Sports Cardiology and Rehab Unit University of Siena Italy, Italy
  7. 7Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
  8. 8Department of Cardiac Surgery, City Hospital of Zurich, Triemli, Zurich, Switzerland
  9. 9Cancer Center, Cantonal Hospital, Chur, Switzerland
  10. 10Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Centre for Population Health Innovation (POINT), University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  11. 11Department of Geoinformatics, Paris Lodron University of Salzburg, Salzburg, Austria
  12. 12Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
  13. 13Neural Control of Movement Lab, Department of Health Sciences and Technology, Institute of Human Movement Sciences and Sport, ETH Zurich, Zurich, Switzerland
  14. 14Department of Medical Biosciences, Exercise Physiology Research Group, Radboud University Medical Centre, Nijmegen, the Netherlands
  15. 15Department of Primary and Community Care, Radboud University Medical Centre, Nijmegen, the Netherlands
  16. 16College of Kinesiology, University of Saskatchewan, Saskatoon, Canada
  17. 17Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland
  18. 18Department of Cardiology, Swiss Heart Center, Inselspital Bern, Bern, 3010, Switzerland
  19. 19First Department of Medicine, University Clinic Salzburg, Paracelsus Medical University, Salzburg, Austria
  20. 20Department of Health Policy, London School of Economics & Political Science, London, UK
  21. 21Swiss Federal Institute for Forest, Snow and Landscape Research (WSL), Birmensdorf, Switzerland
  22. 22Swiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland
  23. 23PSI Center for Energy and Environmental Sciences, Paul Scherrer Institute Villigen, Switzerland
  24. 24HeartClinic, Hirslanden Clinic, Zurich, Switzerland
  25. 25Hochgebirgsklinik, Medicine Campus Davos, Davos, Switzerland; Integrated Cardiovascular Exercise Physiology and Rehabilitation (iCARE) Lab, College of Health Sciences, University of Alberta, Edmonton, Canada
  26. 26Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Cardio-CARE, Medicine Campus Davos, Davos, Switzerland; Centre for Population Health Innovation (POINT), University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Abstract

Background: Cardiac rehabilitation (CR) has been performed in a structured manner since the 1970s, supported by a substantial body of evidence demonstrating its benefits across the heterogeneous pool of cardiac patients. Although therapeutic interventions, pharmacological options, and patient-centered recommendations keep emerging, the majority of CR programs have not changed accordingly. Hence, they are becoming less capable of accounting for an increasingly diverse patient cohort. With a prospective long-term cohort, we aim to achieve an in-depth characterization of CR patients, enabling the delivery of more personalized care in the contemporary era. Methods: In this non-interventional, monocentric, prospective cohort study named RECOVER (Cardiac REhabilitation COhort at the Medicine Campus DaVos to invEstigate Recovery), we plan to include 10,000 patients over 10 years across a broad spectrum of cardiovascular conditions (e.g., cardiac surgery, myocardial infarction, heart failure) with data collected across the full spectrum of inpatient CR. Data acquisition is complemented through extensive biobanking allowing detailed phenotyping and biomarker profiling of patients. Follow-up assessments are conducted at 3 and 6 months, and yearly thereafter, up to 10 years. By harnessing novel devices, digital monitoring is employed to continuously capture a wealth of health-related parameters, such as blood pressure and accelerometry-based physical activity. Addition to the field and limitations: Given the substantial research gap in personalized CR, the RECOVER study provides the opportunity to systematically evaluate recovery patterns and treatment response across distinct cardiovascular subgroups. Due to the unique and highly innovative infrastructure available at the recruiting site, the monocentric design enables performance of an extensive standardized assessment. By incorporating digital technologies in conjunction with deep phenotypic and biomarker data, RECOVER holds promise to enable tailored CR strategies.

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Cite

BibTeXRIS
BibTeX
@article{riess2026rationale,
  title = {{Rationale and design of RECOVER – a prospective, longitudinal cardiac rehabilitation registry}},
  author = {Jan Riess and Elisa Alba Schmidt and Gloria Petrasch and Hadassa Brito Da Silva and Sarah Sichler and Pietro Sartori and Eleonora Di Carluccio and Cornelia Haberfellner and Juliana Senftinger and Miriam Albus and Kathrin Bieri and Claudio Rhyner and Greta Hametner and Luisa M. Prechtl and Meike Distler and Lena Jellestad and Flavio D'Ascenzi and Milena Sokolowska and Hector Rodriguez Cetina Biefer and Omer Dzemali and Roger Von Moos and Raphael Twerenbold and Martin Loidl and Felix C. Tanner and Caroline Lustenberger and Thijs M.H. Eijsvogels and Esmée A. Bakker and Corey R. Tomczak and Aaron Baggish and Simon Kraler and Elmar Aigner and Alex W. Carter and Nicole Bauer and Martin Röösli and Imad El Haddad and Daniel Häuptli and Tsogyal D. Latshang and Jan Steffel and Mark J. Haykowsky and Stefan Blankenberg and Jan Vontobel and Andreas Ziegler and David Niederseer},
  journal = {American Heart Journal Plus},
  year = {2026},
  month = oct,
  doi = {10.1016/j.ahjo.2026.100965},
  url = {https://doi.org/10.1016/j.ahjo.2026.100965},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Rationale and design of RECOVER – a prospective, longitudinal cardiac rehabilitation registry
AU  - Jan Riess
AU  - Elisa Alba Schmidt
AU  - Gloria Petrasch
AU  - Hadassa Brito Da Silva
AU  - Sarah Sichler
AU  - Pietro Sartori
AU  - Eleonora Di Carluccio
AU  - Cornelia Haberfellner
AU  - Juliana Senftinger
AU  - Miriam Albus
AU  - Kathrin Bieri
AU  - Claudio Rhyner
AU  - Greta Hametner
AU  - Luisa M. Prechtl
AU  - Meike Distler
AU  - Lena Jellestad
AU  - Flavio D'Ascenzi
AU  - Milena Sokolowska
AU  - Hector Rodriguez Cetina Biefer
AU  - Omer Dzemali
AU  - Roger Von Moos
AU  - Raphael Twerenbold
AU  - Martin Loidl
AU  - Felix C. Tanner
AU  - Caroline Lustenberger
AU  - Thijs M.H. Eijsvogels
AU  - Esmée A. Bakker
AU  - Corey R. Tomczak
AU  - Aaron Baggish
AU  - Simon Kraler
AU  - Elmar Aigner
AU  - Alex W. Carter
AU  - Nicole Bauer
AU  - Martin Röösli
AU  - Imad El Haddad
AU  - Daniel Häuptli
AU  - Tsogyal D. Latshang
AU  - Jan Steffel
AU  - Mark J. Haykowsky
AU  - Stefan Blankenberg
AU  - Jan Vontobel
AU  - Andreas Ziegler
AU  - David Niederseer
PY  - 2026
DA  - 2026/10/19
JO  - American Heart Journal Plus
DO  - 10.1016/j.ahjo.2026.100965
UR  - https://doi.org/10.1016/j.ahjo.2026.100965
AB  - Background: Cardiac rehabilitation (CR) has been performed in a structured manner since the 1970s, supported by a substantial body of evidence demonstrating its benefits across the heterogeneous pool of cardiac patients. Although therapeutic interventions, pharmacological options, and patient-centered recommendations keep emerging, the majority of CR programs have not changed accordingly. Hence, they are becoming less capable of accounting for an increasingly diverse patient cohort. With a prospective long-term cohort, we aim to achieve an in-depth characterization of CR patients, enabling the delivery of more personalized care in the contemporary era. Methods: In this non-interventional, monocentric, prospective cohort study named RECOVER (Cardiac REhabilitation COhort at the Medicine Campus DaVos to invEstigate Recovery), we plan to include 10,000 patients over 10 years across a broad spectrum of cardiovascular conditions (e.g., cardiac surgery, myocardial infarction, heart failure) with data collected across the full spectrum of inpatient CR. Data acquisition is complemented through extensive biobanking allowing detailed phenotyping and biomarker profiling of patients. Follow-up assessments are conducted at 3 and 6 months, and yearly thereafter, up to 10 years. By harnessing novel devices, digital monitoring is employed to continuously capture a wealth of health-related parameters, such as blood pressure and accelerometry-based physical activity. Addition to the field and limitations: Given the substantial research gap in personalized CR, the RECOVER study provides the opportunity to systematically evaluate recovery patterns and treatment response across distinct cardiovascular subgroups. Due to the unique and highly innovative infrastructure available at the recruiting site, the monocentric design enables performance of an extensive standardized assessment. By incorporating digital technologies in conjunction with deep phenotypic and biomarker data, RECOVER holds promise to enable tailored CR strategies.
SN  - 2666-6022
ER  -