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Peer-reviewedLicence not statedNature Genetics

Population-scale single-nucleus multi-omic profiling of skeletal muscle reveals extensive context-specific genetic regulation

  • Arushi Varshney1,2
  • Nandini Manickam1
  • Peter Orchard1
  • Adelaide Tovar1
  • Christa Ventresca3,1
  • Zhenhao Zhang1
  • Fan Feng1
  • Joseph Mears1
  • Michael R. Erdos4
  • Narisu Narisu4
  • Kirsten Nishino1
  • Vivek Rai1
24 more authors
  • Heather M. Stringham5
  • Anne U. Jackson5
  • Tricia Tamsen6
  • Chao Gao1
  • Mao Yang7
  • Olivia I. Koues6
  • Joshua D. Welch1
  • Charles F. Burant8
  • L. Keoki Williams7
  • Chris Jenkinson9
  • Ralph A. DeFronzo10
  • Luke Norton11,12,10
  • Jouko Saramies13
  • Timo A. Lakka14,15,16
  • Markku Laakso17
  • Jaakko Tuomilehto18,19,20
  • Karen L. Mohlke21
  • Jacob O. Kitzman3,1
  • Heikki A. Koistinen22,18,23,24
  • Jie Liu1
  • Michael Boehnke5
  • Francis S. Collins4
  • Laura J. Scott5
  • Stephen C. J. Parker25,26,27
27 affiliations
  1. 1Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA
  2. 2University of Michigan–Ann Arbor
  3. 3Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA
  4. 4Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
  5. 5Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA
  6. 6Biomedical Research Core Facilities Advanced Genomics Core, University of Michigan, Ann Arbor, MI, USA
  7. 7Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health, Detroit, MI, USA
  8. 8Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
  9. 9South Texas Diabetes and Obesity Research Institute, School of Medicine, University of Texas, Rio Grande Valley, TX, USA
  10. 10Department of Medicine/Diabetes, UT Health San Antonio, San Antonio, TX, USA
  11. 11Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA
  12. 12Department of Cellular and Integrative Physiology, UT Health San Antonio, San Antonio, TX, USA
  13. 13Wellbeing Services County of South Karelia, South Karelia, Finland
  14. 14Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
  15. 15Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
  16. 16Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
  17. 17Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
  18. 18Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
  19. 19Department of Public Health, University of Helsinki, Helsinki, Finland
  20. 20Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
  21. 21Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
  22. 22Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  23. 23Minerva Foundation Institute for Medical Research, Helsinki, Finland
  24. 24University of Helsinki, Faculty of Medicine, Research Programs Unit, Clinical and Molecular Metabolism (CAMM), Helsinki, Finland
  25. 25Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. [email protected]
  26. 26Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA. [email protected]
  27. 27Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. [email protected]
Open at sourceDOICite

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Cite

BibTeXRIS
BibTeX
@article{varshney2026populationscale,
  title = {{Population-scale single-nucleus multi-omic profiling of skeletal muscle reveals extensive context-specific genetic regulation}},
  author = {Arushi Varshney and Nandini Manickam and Peter Orchard and Adelaide Tovar and Christa Ventresca and Zhenhao Zhang and Fan Feng and Joseph Mears and Michael R. Erdos and Narisu Narisu and Kirsten Nishino and Vivek Rai and Heather M. Stringham and Anne U. Jackson and Tricia Tamsen and Chao Gao and Mao Yang and Olivia I. Koues and Joshua D. Welch and Charles F. Burant and L. Keoki Williams and Chris Jenkinson and Ralph A. DeFronzo and Luke Norton and Jouko Saramies and Timo A. Lakka and Markku Laakso and Jaakko Tuomilehto and Karen L. Mohlke and Jacob O. Kitzman and Heikki A. Koistinen and Jie Liu and Michael Boehnke and Francis S. Collins and Laura J. Scott and Stephen C. J. Parker},
  journal = {Nature Genetics},
  year = {2026},
  month = oct,
  doi = {10.1038/s41588-026-02786-6},
  url = {https://doi.org/10.1101/2023.12.15.571696},
}
RIS
TY  - JOUR
TI  - Population-scale single-nucleus multi-omic profiling of skeletal muscle reveals extensive context-specific genetic regulation
AU  - Arushi Varshney
AU  - Nandini Manickam
AU  - Peter Orchard
AU  - Adelaide Tovar
AU  - Christa Ventresca
AU  - Zhenhao Zhang
AU  - Fan Feng
AU  - Joseph Mears
AU  - Michael R. Erdos
AU  - Narisu Narisu
AU  - Kirsten Nishino
AU  - Vivek Rai
AU  - Heather M. Stringham
AU  - Anne U. Jackson
AU  - Tricia Tamsen
AU  - Chao Gao
AU  - Mao Yang
AU  - Olivia I. Koues
AU  - Joshua D. Welch
AU  - Charles F. Burant
AU  - L. Keoki Williams
AU  - Chris Jenkinson
AU  - Ralph A. DeFronzo
AU  - Luke Norton
AU  - Jouko Saramies
AU  - Timo A. Lakka
AU  - Markku Laakso
AU  - Jaakko Tuomilehto
AU  - Karen L. Mohlke
AU  - Jacob O. Kitzman
AU  - Heikki A. Koistinen
AU  - Jie Liu
AU  - Michael Boehnke
AU  - Francis S. Collins
AU  - Laura J. Scott
AU  - Stephen C. J. Parker
PY  - 2026
DA  - 2026/10/28
JO  - Nature Genetics
DO  - 10.1038/s41588-026-02786-6
UR  - https://doi.org/10.1101/2023.12.15.571696
SN  - 1061-4036
SN  - 1546-1718
ER  -