Molecular biology & gene regulation
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6,626 studies
- Single-cell transcriptome analysis of muscle and blood tissues from a patient with a rare homozygous ANO5 variant causing limb-girdle muscular dystrophy type R12
- ogMapper improves speed and memory for short-sequencing read mapping using a novel guided sparse genome index
- The gut-brain-vascular axis: converging neuroinflammatory and hypertension-mediated pathways from gut dysbiosis to cognitive decline
- Deciphering the microbiota-immune axis in adult-onset Still’s disease: evidence from Mendelian randomization and experimental evaluation
- Tissue-specific moderate DNA methylation alterations featuring hypomethylation in microRNA regulatory regions associated with advanced carotid atherosclerosis
- DNA-BFN: Bayesian flow networks for generative modeling of regulatory DNA sequences
- Drosophila Heat Shock Factor (HSF) Regulates Developmental Growth by Maintaining the Basal Expression of HSP83/HSP90
- Unique features of EIGHT fold—Proteins with the most complex 83 knotted topology
- Calibration, accuracy, and domain variation across one million collective forecasts from prediction platforms
- Leveraging existing grid infrastructure for rapid US renewable and storage deployment
- mechanoLight: A genetically encoded fluorescent biosensor for visualizing 5-HT2AR mechanotransduction in live cells
- Scientists disrupt less but more persistently with career aging
- Gastrochilus immaculatus (Orchidaceae, Epidendroideae), a new epiphytic orchid from Chongqing, Southwest China.
- Scutellaria chenhedongensis (Lamiaceae), a new species from Guangzhou, Guangdong, southern China.
- Salvia zayuensis and Salvia toxantha (Lamiaceae), two new species from the Hengduan Mountains, China.
- Novel modifications of small extracellular vesicles to enhance cardiac-specific delivery of siPKA RNA and edaravone against ischemia-reperfusion cardiac injury
- Ellagic acid mitigates follicular atresia in laying chickens via GPX4 upregulation to block ferroptosis and p53 suppression to attenuate DNA damage
- The RES complex core subunits Snu17 and Bud13 buffer the spliceosome against intrinsically weak splicing signals in budding yeast
- Reliable and Efficient Agentic Protein Design with Toolset Harnessing
- PDGFRα-directed fibroblast-homing peptides for targeted delivery of nucleic acid therapeutics
- A rapid, automation-friendly, cell-free and purification-free pipeline for binding and kinetic characterisation of de novo designed binders with high quality standardised per-design data
- Firrm functions as a multiprotein interaction platform that coordinates Mcm8-9-Hrob recruitment and Fignl1-mediated Rad51 unloading
- Constitutive ATR Signaling Enforces Domain-Wide Origin Synchrony
- NEIL2 regulates RNA polymerase II dynamics to suppress transcription replication conflicts in pancreatic cancer
- HaloPROTAC-mediated degradation reveals SOX10-dependent gene expression changes in melanoma cells