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Bioinformatics & computational biology

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2,083 studies

  1. Evaluation design shapes estimates of cross-donor generalization in single-cell classification of cell-type
    Xingyi Chen, Jiabei Li, Alexis Battle
    bioRxivPreprintCC BYFull textBioinformatics & computational biologybioRxivPMC
  2. Cellular context defines brain-specific functions of genes associated with neurodevelopmental disorders
    M. Djokic, S. Karunanithi, M. Welzel +2
    bioRxivPreprintCC BY-NC-NDFull textBioinformatics & computational biologybioRxiv
  3. Steering sequence generation in protein language models through Iterative Lookback Monte Carlo Sampling
    Francesco Calvanese, Gianluca Lombardi, Martin Weigt +1
    Machine Learning : Science and TechnologyPeer-reviewedCC BY 4.0Full textBioinformatics & computational biologyHAL
  4. Pan-genome insights into the evolutionary dynamics and functional diversification of genes in monkeypox virus
    Yan Liu, Yinggen Tang, Yunhai Xu +2
    PeerJPeer-reviewedCC BY 4.0Full textBioinformatics & computational biologyGenetics & genomicsMicrobiologyCrossrefEurope PMCPMC
  5. Extensive mobilome heterogeneity in a widespread endosymbiont: A candidate dimeric plasmid and highly fragmented prophages in Wolbachia from Culex pipiens
    Alice Brunner, Maxime Mahout, Julien Amoros +6
    PLOS GeneticsPeer-reviewedCC BY 4.0Full textBioinformatics & computational biologyGenetics & genomicsZoology & animal behaviourPLOSPMC
  6. A non-allelic homologous recombination-induced inversion in intron 22 of the F8 gene is causative for haemophilia A in a Weimaraner male dog
    Sabrina Pach, Joel Fonseca Nogueira, Bertram Brenig
    PLOS OnePeer-reviewedCC BYFull textBioinformatics & computational biologyGenetics & genomicsPLOSEurope PMC
  7. HelixWings enables AI-driven enzyme engineering for biomimetic cofactor utilization
    Chuanxi Zhang, Yinghui Feng, Ying Ji +13
    iSciencePeer-reviewedCC BY-NC-ND 4.0Full textBioinformatics & computational biologySystems & synthetic biologyCell PressCrossref
  8. Harness engineering enables a multi-agent LLM system to generate cross-domain hypotheses beyond single-investigator reach
    T. Omasa, K. Watanabe
    bioRxivPreprintCC BYFull textBioinformatics & computational biologybioRxiv
  9. Representation learning of somatic missense mutation landscapes across cancer types
    Z.-L. Wang, M. Cai, Z. Li +7
    bioRxivPreprintLicence not statedFull textBioinformatics & computational biologybioRxiv
  10. GLESKit: an MCP-based system for gene-level biomedical investigation and evidence synthesis
    A. Moraes, P. G. Ferreira
    bioRxivPreprintCC BY-NCFull textBioinformatics & computational biologybioRxiv
  11. Separating benchmark discrimination from experimental retrieval in synthetic-lethality prediction
    Z. Huang, R. Huang
    bioRxivPreprintCC BYFull textBioinformatics & computational biologybioRxiv
  12. Benchmarking miRNA Target Prediction Methods
    Congliang Jin, Weibo Niu, Zhexing Wen +2
    arXivPreprintarXiv licenceFull textBioinformatics & computational biologyGenetics & genomicsarXiv
  13. How Much Can AI Virtual Cells Gain from Unified Perturbational Modeling?
    Z. Wei, Y. Ye, S. Cui +2
    bioRxivPreprintCC BY-NCFull textBioinformatics & computational biologybioRxiv
  14. Regularized logistic regression-based gene selection for functional analysis of heterogeneous scRNA-seq macrophage populations in muscle aging and regeneration.
    T. M. Costa, M. B. Lopes, J. Neves +2
    bioRxivPreprintCC BYFull textBioinformatics & computational biologybioRxiv
  15. scRM: A single-cell foundation model trained on scRNA-seq reads
    D. He, R. Patro, M. Nassar +6
    bioRxivPreprintCC BYFull textBioinformatics & computational biologybioRxiv
  16. BaitBench: a comprehensive tool for building, as-sessing, and predicting outcomes for hybrid capture enrichment probes
    A. M. Infante, B. D. Hollingsworth, S. T. Cross
    bioRxivPreprintCC BY-NCFull textBioinformatics & computational biologybioRxiv
  17. Alignment-Free k-mer Analysis Reveals Age-Associated k-mer Signals in Canine Buccal DNA and Cell-Free DNA
    S. Hu, G. D. Vecchio, M. Dlugosz +3
    bioRxivPreprintCC BYFull textBioinformatics & computational biologybioRxiv
  18. Multiscale Transcriptomic Architecture of the ALS Motor Cortex
    A. Goel, S. Pei, G. Alterovitz
    bioRxivPreprintCC BYFull textBioinformatics & computational biologybioRxiv
  19. iGEX: an interactive Gene EXpression exploration platform for the analysis of transcriptomic and proteomic datasets
    S. Saha, J. Whelan, M. W. Murcha
    bioRxivPreprintCC BYFull textBioinformatics & computational biologybioRxiv
  20. Does a map-level insulation constraint improve sequence-based prediction of 3D genome folding? A Stage 1 Registered Report with a reverse-complement-equivariant state-space model (HiFold-Mamba)
    M. Malekpouri, S. Lotfi
    bioRxivPreprintCC BYFull textBioinformatics & computational biologybioRxiv
  21. ProtAgent: Post-Training Compact Protein Tool Agents with Interaction-Level Credit Assignment
    Yuxiang Wang, Baojian Zhou, Qifang Zhao +3
    arXivPreprintarXiv licenceFull textBioinformatics & computational biologyarXiv
  22. Multiscale Topology-Regulated Nonlinear Dynamics for Protein B-Factor Prediction and Single-Cell Type Classification
    Zihan Wang, Mushal Zia, Xiaoqi Wei +2
    arXivPreprintCC BY 4.0Full textBioinformatics & computational biologyarXiv
  23. Identification of gene kinetics patterns improves RNA velocity and cell fate prediction using JuloVelo
    K.-C. Tung, Y.-H. Tu, K.-Y. Hsieh +2
    bioRxivPreprintCC BY-NC-NDFull textBioinformatics & computational biologybioRxiv
  24. In Silico Design and Evaluation of CRISPR Cytosine Base Editing Strategy for Potential Correction of the ASPA Variant Associated with Canavan Disease
    A. Verma, E. Natrajan
    bioRxivPreprintCC BY-NCFull textBioinformatics & computational biologybioRxiv
  25. OTTER: Orchestrated Transcriptomic, Tumor-xenograft (PDX/CDX), and Epigenomic Reporting Workflow
    Y. Zheng, X. Liu, Y. Yi +7
    bioRxivPreprintCC BYFull textBioinformatics & computational biologybioRxiv