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Peer-reviewedCC BY-NC-ND 4.0Alzheimer's & Dementia

APOE‐ε4 carriership and dementia risk over 10 years among Asian American and White older adults

  • Yingyan Wu1,2
  • L. Paloma Rojas‐Saunero1
  • Yixuan Zhou1,3
  • Eleanor Hayes‐Larson1,4
  • Joseph Oliver Fong1
  • Taylor Mobley1
  • Willa D. Brenowitz5,6
  • Thomas J. Hoffmann6,7
  • Kacie D. Deters8
  • Rachel A. Whitmer9,10
  • Paola Gilsanz11
  • Gilbert C. Gee12
2 more authors
  • Ron Brookmeyer3
  • Elizabeth Rose Mayeda1
12 affiliations
  1. 1Department of Epidemiology, Fielding School of Public Health University of California, Los Angeles Los Angeles California USA
  2. 2Department of Epidemiology Boston University School of Public Health Boston Massachusetts USA
  3. 3Department of Biostatistics, Fielding School of Public Health University of California, Los Angeles Los Angeles California USA
  4. 4Leonard Davis School of Gerontology University of Southern California Los Angeles California USA
  5. 5Kaiser Permanente Center for Health Research Portland Oregon USA
  6. 6Department of Epidemiology and Biostatistics University of California, San Francisco San Francisco California USA
  7. 7Office of Research School of Nursing University of California, San Francisco San Francisco California USA
  8. 8Department of Integrative Biology and Physiology University of California Los Angeles California USA
  9. 9Department of Public Health Sciences University of California, Davis Davis California USA
  10. 10Department of Neurology University of California, Davis Sacramento California USA
  11. 11Division of Research Kaiser Permanente Northern California Pleasanton California USA
  12. 12Department of Community Health Sciences, Fielding School of Public Health University of California, Los Angeles Los Angeles California USA
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Abstract

INTRODUCTION: The Apolipoprotein E ε4 allele (APOE‐ε4) is a well‐established dementia risk factor among non‐Latino White individuals but remains understudied among Asian Americans. We estimated its association with dementia risk among Chinese, Japanese, Filipino, and non‐Latino White older adults in California.

METHODS: This longitudinal study included 1078 Chinese, 843 Japanese, 583 Filipino, and 43,821 non‐Latino White participants from the Genetic Epidemiology Research in Adult Health and Aging cohort (mean baseline age = 70 years). Dementia was identified using electronic health records. We estimated effects of APOE‐ε4 carriership on dementia risk using pooled logistic regression.

RESULTS: APOE‐ε4 carriership prevalence ranged from 14% among Filipino to 25% among non‐Latino White participants. APOE‐ε4 carriership was associated with higher dementia risk across groups; 10‐year risk ratios (95% confidence interval [CI]) ranged from 1.59 (0.66–3.10) among Filipino to 1.96 (1.36–2.78) among Japanese participants.

DISCUSSION: Despite differences in prevalence of APOE‐ε4, its association with dementia risk was similar across Chinese, Japanese, Filipino, and non‐Latino White participants.

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Cite

BibTeXRIS
BibTeX
@article{wu2026apoeε4,
  title = {{APOE‐ε4 carriership and dementia risk over 10 years among Asian American and White older adults}},
  author = {Yingyan Wu and L. Paloma Rojas‐Saunero and Yixuan Zhou and Eleanor Hayes‐Larson and Joseph Oliver Fong and Taylor Mobley and Willa D. Brenowitz and Thomas J. Hoffmann and Kacie D. Deters and Rachel A. Whitmer and Paola Gilsanz and Gilbert C. Gee and Ron Brookmeyer and Elizabeth Rose Mayeda},
  journal = {Alzheimer's \& Dementia},
  year = {2026},
  month = jul,
  doi = {10.1002/alz.71615},
  url = {https://doi.org/10.1002/alz.71615},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - APOE‐ε4 carriership and dementia risk over 10 years among Asian American and White older adults
AU  - Yingyan Wu
AU  - L. Paloma Rojas‐Saunero
AU  - Yixuan Zhou
AU  - Eleanor Hayes‐Larson
AU  - Joseph Oliver Fong
AU  - Taylor Mobley
AU  - Willa D. Brenowitz
AU  - Thomas J. Hoffmann
AU  - Kacie D. Deters
AU  - Rachel A. Whitmer
AU  - Paola Gilsanz
AU  - Gilbert C. Gee
AU  - Ron Brookmeyer
AU  - Elizabeth Rose Mayeda
PY  - 2026
DA  - 2026/07/09
JO  - Alzheimer's & Dementia
DO  - 10.1002/alz.71615
UR  - https://doi.org/10.1002/alz.71615
AB  - INTRODUCTION: The Apolipoprotein E ε4 allele (APOE‐ε4) is a well‐established dementia risk factor among non‐Latino White individuals but remains understudied among Asian Americans. We estimated its association with dementia risk among Chinese, Japanese, Filipino, and non‐Latino White older adults in California.  METHODS: This longitudinal study included 1078 Chinese, 843 Japanese, 583 Filipino, and 43,821 non‐Latino White participants from the Genetic Epidemiology Research in Adult Health and Aging cohort (mean baseline age = 70 years). Dementia was identified using electronic health records. We estimated effects of APOE‐ε4 carriership on dementia risk using pooled logistic regression.  RESULTS: APOE‐ε4 carriership prevalence ranged from 14% among Filipino to 25% among non‐Latino White participants. APOE‐ε4 carriership was associated with higher dementia risk across groups; 10‐year risk ratios (95% confidence interval [CI]) ranged from 1.59 (0.66–3.10) among Filipino to 1.96 (1.36–2.78) among Japanese participants.  DISCUSSION: Despite differences in prevalence of APOE‐ε4, its association with dementia risk was similar across Chinese, Japanese, Filipino, and non‐Latino White participants.
SN  - 1552-5260
SN  - 1552-5279
ER  -