Characterization of quantitative susceptibility mapping in the left ventricular myocardium
Abstract
BACKGROUND: * imaging in the assessment of cardiac diseases, including intra-myocardial hemorrhage. However, the precision and repeatability of cardiac QSM have not yet been characterized. The aim of this study is to characterize these key metrics in a healthy volunteer cohort and show the feasibility of the method in patients. METHODS: Free breathing respiratory-navigated multi-echo 3D gradient echo images were acquired, from which QSM maps were reconstructed using the Morphology Enhanced Dipole Inversion toolbox. This technique was first evaluated in a susceptibility phantom containing tubes with known concentrations of gadolinium. In vivo characterization of myocardial QSM was then performed in a cohort of 10 healthy volunteers where each subject was scanned twice. Mean segment susceptibility, precision (standard deviation of voxel magnetic susceptibilities within one segment), and repeatability (absolute difference in segment mean susceptibility between repeats) of QSM were calculated for each American Heart Association (AHA) myocardial segment. Finally, the feasibility of the method was shown in 10 patients, including four with hemorrhagic infarcts. RESULTS: > 0.99). For the healthy volunteer cohort, AHA segment analysis showed the mean segment susceptibility was 0.00 ± 0.02 ppm, the mean precision was 0.05 ± 0.04 ppm, and the mean repeatability was 0.02 ± 0.02 ppm. Cardiac QSM was successfully performed in all patients. Focal iron deposits were successfully visualized in the patients with hemorrhagic myocardial infarctions. CONCLUSION: The precision and repeatability of cardiac QSM were successfully characterized in phantom and in vivo experiments. The feasibility of the technique was also successfully demonstrated in patients. While challenges still remain, further clinical evaluation of the technique is now warranted. TRIAL REGISTRATION: This work does not report on a health care intervention.
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BibTeX
@article{tyler2026characterization,
title = {{Characterization of quantitative susceptibility mapping in the left ventricular myocardium}},
author = {Andrew Tyler and Li Huang and Karl Kunze and Radhouene Neji and Ronald Mooiweer and Charlotte Rogers and Pier Giorgio Masci and Sébastien Roujol},
journal = {Journal of Cardiovascular Magnetic Resonance},
year = {2026},
month = oct,
doi = {10.1016/j.jocmr.2024.101000},
url = {https://hal.science/hal-05795985v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Characterization of quantitative susceptibility mapping in the left ventricular myocardium
AU - Andrew Tyler
AU - Li Huang
AU - Karl Kunze
AU - Radhouene Neji
AU - Ronald Mooiweer
AU - Charlotte Rogers
AU - Pier Giorgio Masci
AU - Sébastien Roujol
PY - 2026
DA - 2026/10/12
JO - Journal of Cardiovascular Magnetic Resonance
DO - 10.1016/j.jocmr.2024.101000
UR - https://hal.science/hal-05795985v1
AB - BACKGROUND: * imaging in the assessment of cardiac diseases, including intra-myocardial hemorrhage. However, the precision and repeatability of cardiac QSM have not yet been characterized. The aim of this study is to characterize these key metrics in a healthy volunteer cohort and show the feasibility of the method in patients. METHODS: Free breathing respiratory-navigated multi-echo 3D gradient echo images were acquired, from which QSM maps were reconstructed using the Morphology Enhanced Dipole Inversion toolbox. This technique was first evaluated in a susceptibility phantom containing tubes with known concentrations of gadolinium. In vivo characterization of myocardial QSM was then performed in a cohort of 10 healthy volunteers where each subject was scanned twice. Mean segment susceptibility, precision (standard deviation of voxel magnetic susceptibilities within one segment), and repeatability (absolute difference in segment mean susceptibility between repeats) of QSM were calculated for each American Heart Association (AHA) myocardial segment. Finally, the feasibility of the method was shown in 10 patients, including four with hemorrhagic infarcts. RESULTS: > 0.99). For the healthy volunteer cohort, AHA segment analysis showed the mean segment susceptibility was 0.00 ± 0.02 ppm, the mean precision was 0.05 ± 0.04 ppm, and the mean repeatability was 0.02 ± 0.02 ppm. Cardiac QSM was successfully performed in all patients. Focal iron deposits were successfully visualized in the patients with hemorrhagic myocardial infarctions. CONCLUSION: The precision and repeatability of cardiac QSM were successfully characterized in phantom and in vivo experiments. The feasibility of the technique was also successfully demonstrated in patients. While challenges still remain, further clinical evaluation of the technique is now warranted. TRIAL REGISTRATION: This work does not report on a health care intervention.
SN - 1097-6647
SN - 1532-429X
ER -