Renal cell carcinoma with venous tumor thrombus in young adults: Distinct clinicopathological features and shorter progression-free survival.
- 1Senior Department of Urology, Chinese PLA General Hospital, Beijing, China.
- 2School of Medicine, Nankai University, Tianjin, China.
- 3Chinese PLA General Hospital Chinese PLA Medical School, Beijing, China.
Abstract
Objectives
This study aimed to characterize the clinicopathological features and survival outcomes of young patients with renal cell carcinoma and venous tumor thrombus (RCC-VTT).Materials and methods
We retrospectively reviewed 468 patients with RCC-VTT who underwent radical nephrectomy and thrombectomy at a high-volume center. Patients were classified as young (≤40 years, n = 43) or older (>40 years, n = 425). Propensity score matching and overlap weighting were used to improve intergroup comparability. Kaplan-Meier analysis and Cox regression were used to evaluate survival outcomes and prognostic associations.Results
Compared with older patients, young patients had larger tumors, more frequent enlarged lymph nodes, more advanced T stages, and greater perioperative transfusion requirements. They also exhibited distinct histological profiles, with higher proportions of papillary RCC and molecularly defined subtypes. Young age was associated with shorter progression-free survival (PFS) in the unadjusted analysis (hazard ratio, 1.79; 95% confidence interval, 1.19-2.70) and remained associated with shorter PFS after accounting for measured clinicopathological characteristics. Across multivariable modeling approaches, young age was consistently retained in the PFS models, together with established prognostic factors, including distant metastasis and nuclear grade.Conclusions
Among patients with RCC-VTT undergoing surgical treatment, young patients exhibited distinct clinicopathological characteristics and shorter PFS. These findings suggest that age-related prognostic differences may not be fully explained by conventional clinicopathological characteristics and warrant further biological investigation.
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BibTeX
@article{li2026renal,
title = {{Renal cell carcinoma with venous tumor thrombus in young adults: Distinct clinicopathological features and shorter progression-free survival.}},
author = {Shichao Li and Xinlin Peng and Jialong Song and Cheng Peng and Yibo Chen and Kan Liu and Zhuo Jia and Qilong Jiao and Changwei Shi and Zhenze Yang and Manwei Huang and Juping Qi and Xu Zhang and Liangyou Gu and Xin Ma and Qingbo Huang},
journal = {Current urology},
year = {2026},
month = sep,
doi = {10.1097/cu9.0000000000000363},
url = {https://europepmc.org/article/MED/42960351},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Renal cell carcinoma with venous tumor thrombus in young adults: Distinct clinicopathological features and shorter progression-free survival.
AU - Shichao Li
AU - Xinlin Peng
AU - Jialong Song
AU - Cheng Peng
AU - Yibo Chen
AU - Kan Liu
AU - Zhuo Jia
AU - Qilong Jiao
AU - Changwei Shi
AU - Zhenze Yang
AU - Manwei Huang
AU - Juping Qi
AU - Xu Zhang
AU - Liangyou Gu
AU - Xin Ma
AU - Qingbo Huang
PY - 2026
DA - 2026/09/22
JO - Current urology
DO - 10.1097/cu9.0000000000000363
UR - https://europepmc.org/article/MED/42960351
AB - Objectives This study aimed to characterize the clinicopathological features and survival outcomes of young patients with renal cell carcinoma and venous tumor thrombus (RCC-VTT).Materials and methods We retrospectively reviewed 468 patients with RCC-VTT who underwent radical nephrectomy and thrombectomy at a high-volume center. Patients were classified as young (≤40 years, n = 43) or older (>40 years, n = 425). Propensity score matching and overlap weighting were used to improve intergroup comparability. Kaplan-Meier analysis and Cox regression were used to evaluate survival outcomes and prognostic associations.Results Compared with older patients, young patients had larger tumors, more frequent enlarged lymph nodes, more advanced T stages, and greater perioperative transfusion requirements. They also exhibited distinct histological profiles, with higher proportions of papillary RCC and molecularly defined subtypes. Young age was associated with shorter progression-free survival (PFS) in the unadjusted analysis (hazard ratio, 1.79; 95% confidence interval, 1.19-2.70) and remained associated with shorter PFS after accounting for measured clinicopathological characteristics. Across multivariable modeling approaches, young age was consistently retained in the PFS models, together with established prognostic factors, including distant metastasis and nuclear grade.Conclusions Among patients with RCC-VTT undergoing surgical treatment, young patients exhibited distinct clinicopathological characteristics and shorter PFS. These findings suggest that age-related prognostic differences may not be fully explained by conventional clinicopathological characteristics and warrant further biological investigation.
SN - 1661-7649
SN - 1661-7657
ER -