Contrast media extravasation following CT angiography in a patient with lower-extremity atherosclerotic occlusive disease: a case report
- 1Vascular Disease Center, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine , ,
Abstract
Contrast media extravasation (CME) is a recognized complication of intravenous iodinated contrast administration during computed tomography (CT) examinations, with a reported incidence rate ranging between 0.1% and 1.2%. Although most extravasation injuries are mild and self-limiting, a small proportion of them progress to skin blistering, tissue necrosis, or compartment syndrome. Blister formation, in particular, is an uncommon manifestation observed predominantly in moderate-to-severe extravasation. Herein, we report a case of iobitridol extravasation that occurred during lower-extremity CT angiography in a 68-year-old female patient with lower-extremity atherosclerotic occlusive disease. Approximately 5 h after the procedure, multiple fluid-filled skin blisters developed at the forearm injection site. A combined external regimen-topical Hirudoid (mucopolysaccharide polysulfate) cream, intermittent ice compresses, and Jinhuang San (Golden Yellow Powder) mixed with green-tea water as a wet poultice was applied immediately. The blisters were absorbed by the following day without skin breakdown, and complete resolution was achieved within 48 h. To our knowledge, this is the first report describing this specific three-component topical combination for iobitridol extravasation presenting with blistering. This case highlights the importance of early recognition and structured topical management of CME and suggests-at the hypothesis-generating level-that integrating a traditional Chinese medicine external therapy with conventional topical agents may be a useful option for such injuries. Prospective, controlled studies are required to confirm these observations.
Related
- Scoring balloon versus plain balloon vessel preparation before drug-coated balloon angioplasty for femoropopliteal atherosclerotic occlusive disease: a two-centre retrospective cohort study
- Effectiveness of Discrete Strategies and Implementation Bundles for Improving Clinician Prescription of Clinical Practice Guideline–Recommended Medications for Atherosclerotic Occlusive Disease: A Systematic Review and Meta‐Analysis
- Carotid atherosclerotic plaque characterization using dual-energy computed tomography angiography and its correlation with cerebral ischemic stroke
- Case Report: Renal rupture and massive urine extravasation following flexible ureteroscopic lithotripsy: analysis of 4 cases and literature review
- Angiography-derived fractional flow and clinical outcomes in symptomatic intracranial atherosclerotic stenosis
BibTeX
@article{yan2026contrast,
title = {{Contrast media extravasation following CT angiography in a patient with lower-extremity atherosclerotic occlusive disease: a case report}},
author = {CongBing Yan and Ting Zhang and Qin Xu and Shiyuan Bi},
journal = {Frontiers in medicine},
year = {2026},
month = oct,
doi = {10.3389/fmed.2026.1888394},
url = {https://europepmc.org/article/PMC/PMC13716790},
note = {CC BY},
}
RIS
TY - JOUR
TI - Contrast media extravasation following CT angiography in a patient with lower-extremity atherosclerotic occlusive disease: a case report
AU - CongBing Yan
AU - Ting Zhang
AU - Qin Xu
AU - Shiyuan Bi
PY - 2026
DA - 2026/10/15
JO - Frontiers in medicine
DO - 10.3389/fmed.2026.1888394
UR - https://europepmc.org/article/PMC/PMC13716790
AB - Contrast media extravasation (CME) is a recognized complication of intravenous iodinated contrast administration during computed tomography (CT) examinations, with a reported incidence rate ranging between 0.1% and 1.2%. Although most extravasation injuries are mild and self-limiting, a small proportion of them progress to skin blistering, tissue necrosis, or compartment syndrome. Blister formation, in particular, is an uncommon manifestation observed predominantly in moderate-to-severe extravasation. Herein, we report a case of iobitridol extravasation that occurred during lower-extremity CT angiography in a 68-year-old female patient with lower-extremity atherosclerotic occlusive disease. Approximately 5 h after the procedure, multiple fluid-filled skin blisters developed at the forearm injection site. A combined external regimen-topical Hirudoid (mucopolysaccharide polysulfate) cream, intermittent ice compresses, and Jinhuang San (Golden Yellow Powder) mixed with green-tea water as a wet poultice was applied immediately. The blisters were absorbed by the following day without skin breakdown, and complete resolution was achieved within 48 h. To our knowledge, this is the first report describing this specific three-component topical combination for iobitridol extravasation presenting with blistering. This case highlights the importance of early recognition and structured topical management of CME and suggests-at the hypothesis-generating level-that integrating a traditional Chinese medicine external therapy with conventional topical agents may be a useful option for such injuries. Prospective, controlled studies are required to confirm these observations.
SN - 2296-858X
ER -