DYSBIOSIS OF GUT MICROBIOTA IN PATIENTS HOSPITALIZED FOR THE TREATMENT OF ALCOHOL USE DISORDER.
6 affiliations
- 1Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Gastroenterologia e Hepatologia, Porto Alegre, RS, Brasil.
- 2Hospital de Clínicas de Porto Alegre, Centro de Pesquisa Experimental, Laboratório Experimental de Hepatologia e Gastroenterologia, Porto Alegre, RS, Brasil.
- 3Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Porto Alegre, RS, Brasil.
- 4Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Porto Alegre, RS, Brasil.
- 5Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Centro de Pesquisas sobre Drogas e Álcool e Centro Colaborador em Álcool e Drogas, Porto Alegre, RS, Brasil.
- 6Hospital de Clínicas de Porto Alegre, Divisão de Gastroenterologia, Porto Alegre, RS, Brasil.
Abstract
Background and objectives
Alcohol Use Disorder (AUD) is a global issue with a significant financial impact on health. The main objective of this study was to assess the chronic effect of alcohol on the composition and diversity of intestinal microbiota in AUD patients.Methods
Prospective cohort study in patients hospitalized for AUD treatment. Demographic, clinical, and laboratory data and inflammatory markers were assessed at the time of hospital admission for AUD-T1-group and in the control group, as well evaluation of the gut microbiota composition, while the AUD-T2-group was assessed at the discharge from hospital treatment.Results
50 participants were included in the control group and 47 admitted for AUD treatment. The mean age in the AUD-T1-group was 49.3 years, all male. Mieloperoxidase concentration was significantly higher in AUD-T1-group compared to control (P<0.001). The opposite was observed for E-selectin (P<0.001). Global alpha diversity was different among the control, AUD-T1 and AUD-T2 groups, ACE index (P<0.004), Shannon index (P<0.017), observed taxa (P=0.002). The LEfSe algorithm identified a higher abundance of Faecalibacterium, Bacteroides, Agathobacter, and Ruminococcaceae unclassified in control compared to the AUD-T1. There were no differences in the abundance of bacterial genera between the AUD-T1 and AUD-T2 groups.Conclusion
Patients with AUD exhibit changes in intestinal microbiota composition, potentially associated with low-grade inflammation and functional alterations that contribute to the development of diseases. The composition of intestinal microbiota and its bioactive metabolites may serve as novel therapeutic targets for the treatment of AUD.
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BibTeX
@article{thoen2026dysbiosis,
title = {{DYSBIOSIS OF GUT MICROBIOTA IN PATIENTS HOSPITALIZED FOR THE TREATMENT OF ALCOHOL USE DISORDER.}},
author = {Rutiane Ullmann Thoen and Larisse Longo and Bruno de Souza Basso and Pabulo Henrique Rampelotto and Anne Orgler Sordi and Félix Henrique Paim Kessler and Lisia Von Diemen and Mário Reis Álvares-DA-Silva},
journal = {Arquivos de gastroenterologia},
year = {2026},
month = oct,
doi = {10.1590/s0004-2803.24612025-144},
url = {https://europepmc.org/article/MED/42961248},
note = {CC BY},
}
RIS
TY - JOUR
TI - DYSBIOSIS OF GUT MICROBIOTA IN PATIENTS HOSPITALIZED FOR THE TREATMENT OF ALCOHOL USE DISORDER.
AU - Rutiane Ullmann Thoen
AU - Larisse Longo
AU - Bruno de Souza Basso
AU - Pabulo Henrique Rampelotto
AU - Anne Orgler Sordi
AU - Félix Henrique Paim Kessler
AU - Lisia Von Diemen
AU - Mário Reis Álvares-DA-Silva
PY - 2026
DA - 2026/10/26
JO - Arquivos de gastroenterologia
DO - 10.1590/s0004-2803.24612025-144
UR - https://europepmc.org/article/MED/42961248
AB - Background and objectives Alcohol Use Disorder (AUD) is a global issue with a significant financial impact on health. The main objective of this study was to assess the chronic effect of alcohol on the composition and diversity of intestinal microbiota in AUD patients.Methods Prospective cohort study in patients hospitalized for AUD treatment. Demographic, clinical, and laboratory data and inflammatory markers were assessed at the time of hospital admission for AUD-T1-group and in the control group, as well evaluation of the gut microbiota composition, while the AUD-T2-group was assessed at the discharge from hospital treatment.Results 50 participants were included in the control group and 47 admitted for AUD treatment. The mean age in the AUD-T1-group was 49.3 years, all male. Mieloperoxidase concentration was significantly higher in AUD-T1-group compared to control (P<0.001). The opposite was observed for E-selectin (P<0.001). Global alpha diversity was different among the control, AUD-T1 and AUD-T2 groups, ACE index (P<0.004), Shannon index (P<0.017), observed taxa (P=0.002). The LEfSe algorithm identified a higher abundance of Faecalibacterium, Bacteroides, Agathobacter, and Ruminococcaceae unclassified in control compared to the AUD-T1. There were no differences in the abundance of bacterial genera between the AUD-T1 and AUD-T2 groups.Conclusion Patients with AUD exhibit changes in intestinal microbiota composition, potentially associated with low-grade inflammation and functional alterations that contribute to the development of diseases. The composition of intestinal microbiota and its bioactive metabolites may serve as novel therapeutic targets for the treatment of AUD.
SN - 0004-2803
SN - 1678-4219
ER -