Skip to content
DraconiticResearch
Search Sources API
190,869 studies31 sourcesUpdated 31 min ago
Peer-reviewedCC BYNew microbes and new infections

Prostate tissue microbiota dysbiosis associated with prostate cancer: results from the MICROPROSTK multicenter study.

  • R Lotte1,2,3
  • A Gaudart1
  • C Cruzel4
  • S Droupy5
  • J P Lavigne6
  • F Bruyère7
  • P Lanotte8
  • E Lechevallier9
  • G Dubourg10
  • P E Fournier10
  • R Haider11
  • L Lotte12
12 more authors
  • K Youssef13
  • A Emery1
  • R Madany1
  • M Payen1
  • L Pfauwadel1
  • B Tibi14
  • Y Ahallal14
  • S Zouari14
  • I Bentellis14
  • E Fontas4
  • M Durand14
  • R Ruimy1,2,3
14 affiliations
  1. 1Laboratoire de Bactériologie du CHU de Nice, Hôpital Archet 2, Nice, France.
  2. 2Inserm U1065, Centre Méditerranéen de Médecine Moléculaire, Équipe 6, Nice, France.
  3. 3Université Cote d'Azur, Faculté de Médecine de Nice, Nice, France.
  4. 4Délégation à la Recherche Clinique et à l'Innovation du CHU de Nice, Hôpital de Cimiez, Nice, France.
  5. 5Service d'Urologie du CHU de Nîmes, Hôpital Carémeau, Nîmes, France.
  6. 6Laboratoire de Microbiologie du CHU de Nîmes, Hôpital Carémeau, Nîmes, France.
  7. 7Service d'Urologie du CHU de Tours, Hôpital Bretonneau, Tours, France.
  8. 8Laboratoire de Bactériologie du CHU de Tours, Hôpital Bretonneau, Tours, France.
  9. 9Service d'Urologie de l'APHM, Hôpital la Conception, Marseille, France.
  10. 10Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France.
  11. 11Service d'Urologie du CH de Cannes, Hôpital Simone Veil, Cannes, France.
  12. 12Laboratoire de Biologie du CH de Cannes, Hôpital Simone Veil, Cannes, France.
  13. 13Service d'Urologie du CH de Menton, Hôpital La Palmosa, Menton, France.
  14. 14Service d'Urologie du CHU de Nice, Hôpital Pasteur 2, Nice, France.
Read full textPDFDOICite

Abstract

•The prostate harbors a diverse and previously undercharacterized microbial ecosystem with species-level resolution.•Prostate cancer (PCa) patients exhibit higher microbial richness and α-diversity in prostate tissue than non PCa patients.•Distinct microbial communities are observed across prostate, urinary, and rectal niches, independent of cancer status.•Cutibacterium acnes is enriched in PCa patients' biopsies, Lactobacillus reuteri in non-PCa patients' biopsies.•Findings highlight potential prostate-associated pathobionts and protective commensalssignatures.

Related

  1. Gut microbiota composition and dysbiosis signatures associated with complex gastrointestinal and urological conditions in neonates: a case series study
    Marsiglia Riccardo, Domenico Umberto De Rose, Pane Stefania +9
    Frontiers in MedicinePeer-reviewedCC BYFull textMolecular biology & gene regulationDOAJ
  2. High-fat diet induces an adaptive dysbiosis in the gut microbiota, associated with oxidative stress and the gut resistome profile in a rat model
    Fernanda Figueroa-Ajraz, Erik Bongcam-Rudloff, Karoll González-Pizarro +4
    Frontiers in MicrobiologyPeer-reviewedCC BY 4.0Full textMolecular biology & gene regulationCrossrefEurope PMC
  3. Gut microbiota modulation of gastrointestinal cancers: from dysbiosis signatures to therapeutic interventions
    Xin-yu Li, Zuo-quan Xie, Mei-yu Geng
    Acta Pharmacologica SinicaPeer-reviewedLicence not statedFull text1 citedMolecular biology & gene regulationPMC
  4. From Dysbiosis to Disease: How Vaginal Microbiota Shape Group B Streptococcus Pathogenesis
    Julie A. Talbert, Steven D. Townsend
    Chembiochem : a European journal of chemical biologyPeer-reviewedCC BYFull textMolecular biology & gene regulationEurope PMC
  5. Integrating Mendelian randomization with single-cell and spatial transcriptomics to investigate gut microbiota-associated genetic signals and molecular characteristics in prostate cancer.
    Chenjie Qiu, Huilin Zhang, Zongmin Du +2
    Frontiers in cellular and infection microbiologyPeer-reviewedCC BYFull textMolecular biology & gene regulationEurope PMC

Cite

BibTeXRIS
BibTeX
@article{lotte2026prostate,
  title = {{Prostate tissue microbiota dysbiosis associated with prostate cancer: results from the MICROPROSTK multicenter study.}},
  author = {R Lotte and A Gaudart and C Cruzel and S Droupy and J P Lavigne and F Bruyère and P Lanotte and E Lechevallier and G Dubourg and P E Fournier and R Haider and L Lotte and K Youssef and A Emery and R Madany and M Payen and L Pfauwadel and B Tibi and Y Ahallal and S Zouari and I Bentellis and E Fontas and M Durand and R Ruimy},
  journal = {New microbes and new infections},
  year = {2026},
  month = oct,
  doi = {10.1016/j.nmni.2026.101862},
  url = {https://europepmc.org/article/MED/42904090},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Prostate tissue microbiota dysbiosis associated with prostate cancer: results from the MICROPROSTK multicenter study.
AU  - R Lotte
AU  - A Gaudart
AU  - C Cruzel
AU  - S Droupy
AU  - J P Lavigne
AU  - F Bruyère
AU  - P Lanotte
AU  - E Lechevallier
AU  - G Dubourg
AU  - P E Fournier
AU  - R Haider
AU  - L Lotte
AU  - K Youssef
AU  - A Emery
AU  - R Madany
AU  - M Payen
AU  - L Pfauwadel
AU  - B Tibi
AU  - Y Ahallal
AU  - S Zouari
AU  - I Bentellis
AU  - E Fontas
AU  - M Durand
AU  - R Ruimy
PY  - 2026
DA  - 2026/10/08
JO  - New microbes and new infections
DO  - 10.1016/j.nmni.2026.101862
UR  - https://europepmc.org/article/MED/42904090
AB  - •The prostate harbors a diverse and previously undercharacterized microbial ecosystem with species-level resolution.•Prostate cancer (PCa) patients exhibit higher microbial richness and α-diversity in prostate tissue than non PCa patients.•Distinct microbial communities are observed across prostate, urinary, and rectal niches, independent of cancer status.•Cutibacterium acnes is enriched in PCa patients' biopsies, Lactobacillus reuteri in non-PCa patients' biopsies.•Findings highlight potential prostate-associated pathobionts and protective commensalssignatures.
SN  - 2052-2975
ER  -