Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 35 min ago
Peer-reviewedCC BY-NC 4.0Pediatric Pulmonology

A Delphi‐Based Item Set for Pre‐Test Asthma Probability Assessment in Children Undergoing Methacholine Challenge Test

  • Tahani Ibrahim1
  • Alessia Mariani1,2
  • Maxime Beydon3
  • Juliette Dardenne1
  • Marc Koskas1
  • Alexandra Costea1
  • Lucia Maingot1
  • Jessica Taytard1,4
  • Nicole Beydon1,5
5 affiliations
  1. 1Sorbonne Université, APHP, Hôpital Armand Trousseau, Unité Fonctionnelle d'Explorations Fonctionnelles Respiratoire et Somnologie Paris Île‐de‐France France
  2. 2Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pediatria Pneumoinfettivologia Milan Lombardy Italy
  3. 3Département de Santé Publique Sorbonne Université, INSERM, Sorbonne Public Health Institute, Team PEPITES, AP‐HP, Hôpital Pitié Salpêtrière Paris Île‐de‐France France
  4. 4INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique Paris Île‐de‐France France
  5. 5INSERM U938, Centre de Recherche Saint Antoine Paris Île‐de‐France France
Read full textPDFDOICite

Abstract

Objective: To select, through a Delphi consensus process, the clinical items most relevant to pre‐test probability of asthma (PTPA) in children undergoing methacholine challenge test (MCT) and to explore their association with expert‐estimated PTPA.

Working Hypothesis: Delphi‐selected items are associated with PTPA estimated independently by pediatric pulmonologists.

Study Design: Three‐round e‐Delphi, followed by a retrospective analysis of item association with expert‐estimated PTPA. Patient‐subject selection: A database of 92 children referred for MCT at a tertiary center.

Methodology: A steering committee proposed 11 candidate items, rated by 23 experts (consensus threshold ≥ 80%). Five pediatric pulmonologists, blinded to MCT results and not involved in the Delphi, independently estimated PTPA from clinical history. Agreement was assessed with intraclass correlation coefficients (ICC). Associations between retained items and mean PTPA were assessed using a multivariable linear regression.

Results: Ten items were retained (nine reached consensus; pneumonia/atelectasis was retained by steering‐committee judgment). Single‐rater ICC was 0.78 (95% CI 0.70–0.85); average‐measures ICC was 0.95 (95% CI 0.92–0.97). Multivariable linear regression retained all ten items; each positively associated with PTPA. The strongest associations were seen with wheezing after age 3 years (β 15, 95% CI 7.4–23), wheezing within the last 3 years (β 14, 95% CI 6.4–22) and complete response to anti‐asthma treatment with relapse after treatment cessation (β 34, 95% CI 27–41).

Conclusion: Delphi consensus identified ten clinically relevant items, all associated with expert‐estimated PTPA. As the outcome was expert judgement rather than confirmed asthma, diagnostic value remains unestablished; outcome‐based studies are needed.

Related

  1. Assessment of Nurses` Performance regarding Care of Children with Pleural Empyema Undergoing Lung Decortication
    Rahma Bahgat, Marwa Elsayed Elslemy, Nagwa Baraka
    Tanta Scientific Nursing JournalPeer-reviewedCC BYFull textGeneral medicineDOAJ
  2. Acyclovir and ganciclovir exposure and short-term outcomes in hospitalized children with EBV-associated mononucleosis-like illness: a retrospective cohort study using inverse probability of treatment weighting
    Ying Ding, Qinghui Chen, Ruyue Chen +1
    Translational pediatricsPeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC
  3. Exceedance Probability and Toxicity-Value Sensitivity in Health-Risk Assessment of a Pb–Zn Slag Reprocessing Site Under the 2025 IRIS Arsenic Values
    Zhaksylyk Pernebayev, Akmaral Issayeva, Togzhan Baiduisenova +3
    ToxicsPeer-reviewedCC BYFull textPharmacology & toxicologyEurope PMC
  4. Commentary: Assessment of real-world surveillance strategies for patients undergoing systemic therapy for brain metastases
    Xiaoxia Zhang, Guanjie Wang, Xiaoling Guo +1
    Frontiers in OncologyPeer-reviewedCC BY 4.0OncologyFrontiersCrossref
  5. Generative Artificial Intelligence in Periodontology: Application of OpenAI Models for the Classification of Periodontitis and Risk Assessment in Patients Undergoing Supportive Periodontal Care
    Albert Camlet, Aida Kusiak, Dariusz Świetlik
    Journal of clinical medicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{ibrahim2026delphibased,
  title = {{A Delphi‐Based Item Set for Pre‐Test Asthma Probability Assessment in Children Undergoing Methacholine Challenge Test}},
  author = {Tahani Ibrahim and Alessia Mariani and Maxime Beydon and Juliette Dardenne and Marc Koskas and Alexandra Costea and Lucia Maingot and Jessica Taytard and Nicole Beydon},
  journal = {Pediatric Pulmonology},
  year = {2026},
  month = nov,
  doi = {10.1002/ppul.71903},
  url = {https://doi.org/10.1002/ppul.71903},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - A Delphi‐Based Item Set for Pre‐Test Asthma Probability Assessment in Children Undergoing Methacholine Challenge Test
AU  - Tahani Ibrahim
AU  - Alessia Mariani
AU  - Maxime Beydon
AU  - Juliette Dardenne
AU  - Marc Koskas
AU  - Alexandra Costea
AU  - Lucia Maingot
AU  - Jessica Taytard
AU  - Nicole Beydon
PY  - 2026
DA  - 2026/11/03
JO  - Pediatric Pulmonology
DO  - 10.1002/ppul.71903
UR  - https://doi.org/10.1002/ppul.71903
AB  - Objective: To select, through a Delphi consensus process, the clinical items most relevant to pre‐test probability of asthma (PTPA) in children undergoing methacholine challenge test (MCT) and to explore their association with expert‐estimated PTPA.  Working Hypothesis: Delphi‐selected items are associated with PTPA estimated independently by pediatric pulmonologists.  Study Design: Three‐round e‐Delphi, followed by a retrospective analysis of item association with expert‐estimated PTPA. Patient‐subject selection: A database of 92 children referred for MCT at a tertiary center.  Methodology: A steering committee proposed 11 candidate items, rated by 23 experts (consensus threshold ≥ 80%). Five pediatric pulmonologists, blinded to MCT results and not involved in the Delphi, independently estimated PTPA from clinical history. Agreement was assessed with intraclass correlation coefficients (ICC). Associations between retained items and mean PTPA were assessed using a multivariable linear regression.  Results: Ten items were retained (nine reached consensus; pneumonia/atelectasis was retained by steering‐committee judgment). Single‐rater ICC was 0.78 (95% CI 0.70–0.85); average‐measures ICC was 0.95 (95% CI 0.92–0.97). Multivariable linear regression retained all ten items; each positively associated with PTPA. The strongest associations were seen with wheezing after age 3 years (β 15, 95% CI 7.4–23), wheezing within the last 3 years (β 14, 95% CI 6.4–22) and complete response to anti‐asthma treatment with relapse after treatment cessation (β 34, 95% CI 27–41).  Conclusion: Delphi consensus identified ten clinically relevant items, all associated with expert‐estimated PTPA. As the outcome was expert judgement rather than confirmed asthma, diagnostic value remains unestablished; outcome‐based studies are needed.
SN  - 8755-6863
SN  - 1099-0496
ER  -