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Peer-reviewedCC BY 4.0Nanomaterials

Harnessing Nanozyme Catalytic Activities for Multi-Target Intervention in Neurodegenerative Pathology

  • Yanan Wang1,2
  • Jintao Cheng1
  • Tao Liu1
  • Shiyu Li1
  • Qingchi Wang1
  • Kan Shao1,3
  • Guiling Yang1,4
  • Peiwu Li1,2
4 affiliations
  1. 1Xianghu Laboratory, Zhejiang Provincial Laboratory of Agriculture, Biomanufacturing Research Institute, Hangzhou 311231, China
  2. 2Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China
  3. 3Department of Environmental and Occupational Health, School of Public Health, Indiana University, Bloomington, IN 47405, USA
  4. 4State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Laboratory (Hangzhou) for Risk Assessment of Agricultural Products of Ministry of Agriculture, Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China
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Abstract

The therapeutic landscape for neurodegenerative diseases (NDs), including Alzheimer’s and Parkinson’s disease, remains challenging due to their complex, multifactorial pathogenesis and the limited efficacy of conventional therapies that primarily offer symptomatic relief. The emergence of nanozymes, nanomaterials with intrinsic enzyme-mimicking activities, presents a promising opportunity for multi-targeted intervention. This review comprehensively explores the rational design and therapeutic mechanisms of nanozymes in combating core pathological features of NDs, such as oxidative stress, protein aggregation, and neuroinflammation. We critically assess their remarkable ability to cross the blood–brain barrier and execute synergistic functions, including reactive oxygen species scavenging, misfolded protein degradation, and modulation of microglial activation. Furthermore, we provide a detailed analysis of the application and efficacy of nanozymes across major NDs, alongside a discussion on pharmacokinetics, biosafety, and prevailing challenges. By delineating the structure-enzyme-mimicking activity relationships and cellular-level mechanisms, this review aims to establish a foundational framework for the future development of nanozyme-based neuroprotective strategies, supporting ongoing efforts toward disease-modifying interventions for NDs.

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Cite

BibTeXRIS
BibTeX
@article{wang2026harnessing,
  title = {{Harnessing Nanozyme Catalytic Activities for Multi-Target Intervention in Neurodegenerative Pathology}},
  author = {Yanan Wang and Jintao Cheng and Tao Liu and Shiyu Li and Qingchi Wang and Kan Shao and Guiling Yang and Peiwu Li},
  journal = {Nanomaterials},
  year = {2026},
  month = oct,
  doi = {10.3390/nano16211355},
  url = {https://www.mdpi.com/2079-4991/16/21/1355},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Harnessing Nanozyme Catalytic Activities for Multi-Target Intervention in Neurodegenerative Pathology
AU  - Yanan Wang
AU  - Jintao Cheng
AU  - Tao Liu
AU  - Shiyu Li
AU  - Qingchi Wang
AU  - Kan Shao
AU  - Guiling Yang
AU  - Peiwu Li
PY  - 2026
DA  - 2026/10/25
JO  - Nanomaterials
DO  - 10.3390/nano16211355
UR  - https://www.mdpi.com/2079-4991/16/21/1355
AB  - The therapeutic landscape for neurodegenerative diseases (NDs), including Alzheimer’s and Parkinson’s disease, remains challenging due to their complex, multifactorial pathogenesis and the limited efficacy of conventional therapies that primarily offer symptomatic relief. The emergence of nanozymes, nanomaterials with intrinsic enzyme-mimicking activities, presents a promising opportunity for multi-targeted intervention. This review comprehensively explores the rational design and therapeutic mechanisms of nanozymes in combating core pathological features of NDs, such as oxidative stress, protein aggregation, and neuroinflammation. We critically assess their remarkable ability to cross the blood–brain barrier and execute synergistic functions, including reactive oxygen species scavenging, misfolded protein degradation, and modulation of microglial activation. Furthermore, we provide a detailed analysis of the application and efficacy of nanozymes across major NDs, alongside a discussion on pharmacokinetics, biosafety, and prevailing challenges. By delineating the structure-enzyme-mimicking activity relationships and cellular-level mechanisms, this review aims to establish a foundational framework for the future development of nanozyme-based neuroprotective strategies, supporting ongoing efforts toward disease-modifying interventions for NDs.
SN  - 2079-4991
ER  -