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Peer-reviewedCC BY-NC 4.0Iranian Journal of Microbiology

Analysis of gene expression patterns in various topographic sites of gastritis patients infected with Helicobacter pylori

  • Sahar Sarrafzadeh Zargar1
  • Masoumeh Anvari1
  • Amir Sadeghi2
  • Abbas Yadegar3
  1. 1Department of Biology, Ra.C., Islamic Azad University, Rasht, Iran
  2. 2Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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Abstract

Background and Objectives:: Helicobacter pylori infection primarily contributes to gastric carcinogenesis. This study examined the expression of cyclin E1, β-catenin, PPAR-δ, and miR-9 in different gastric regions of gastritis patients with and without H. pylori infection.

Materials and Methods:: Gastric biopsies were obtained from 108 participants divided into three groups, including healthy (n = 15), gastritis (n = 53), and H. pylori-positive gastritis (n = 40). Bacterial culture and molecular characterization were performed to confirm H. pylori presence. Gene expression was assessed using SYBR Green-based RT-qPCR. Statistical analyses revealed correlations between the expression of cyclin E1, β-catenin, PPAR-δ, miR-9, and the presence of H. pylori in patients with gastritis compared to healthy controls.

Results:: The cagA-positive strains were significantly associated with the expression of cyclin E1, β-catenin, PPAR-δ (P < 0.001), and miR-9 (P < 0.01). Cyclin E1 and β-catenin expression were upregulated in gastritis and H. pylori-positive gastritis patients. The PPAR-δ expression was highest in H. pylori-positive gastritis patients, specifically in the antrum tissues. miR-9 showed significant downregulation in H. pylori-positive gastritis samples.

Conclusion:: cagA-positive H. pylori infection was linked to distinct gene expression changes that varied by gastric region. Further studies are needed to explore the mechanisms involved.

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Cite

BibTeXRIS
BibTeX
@article{zargar2026analysis,
  title = {{Analysis of gene expression patterns in various topographic sites of gastritis patients infected with Helicobacter pylori}},
  author = {Sahar Sarrafzadeh Zargar and Masoumeh Anvari and Amir Sadeghi and Abbas Yadegar},
  journal = {Iranian Journal of Microbiology},
  year = {2026},
  month = nov,
  doi = {10.18502/ijm.v18i5.22868},
  url = {https://doi.org/10.18502/ijm.v18i5.22868},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Analysis of gene expression patterns in various topographic sites of gastritis patients infected with Helicobacter pylori
AU  - Sahar Sarrafzadeh Zargar
AU  - Masoumeh Anvari
AU  - Amir Sadeghi
AU  - Abbas Yadegar
PY  - 2026
DA  - 2026/11/06
JO  - Iranian Journal of Microbiology
DO  - 10.18502/ijm.v18i5.22868
UR  - https://doi.org/10.18502/ijm.v18i5.22868
AB  - Background and Objectives:: Helicobacter pylori infection primarily contributes to gastric carcinogenesis. This study examined the expression of cyclin E1, β-catenin, PPAR-δ, and miR-9 in different gastric regions of gastritis patients with and without H. pylori infection.  Materials and Methods:: Gastric biopsies were obtained from 108 participants divided into three groups, including healthy (n = 15), gastritis (n = 53), and H. pylori-positive gastritis (n = 40). Bacterial culture and molecular characterization were performed to confirm H. pylori presence. Gene expression was assessed using SYBR Green-based RT-qPCR. Statistical analyses revealed correlations between the expression of cyclin E1, β-catenin, PPAR-δ, miR-9, and the presence of H. pylori in patients with gastritis compared to healthy controls.  Results:: The cagA-positive strains were significantly associated with the expression of cyclin E1, β-catenin, PPAR-δ (P < 0.001), and miR-9 (P < 0.01). Cyclin E1 and β-catenin expression were upregulated in gastritis and H. pylori-positive gastritis patients. The PPAR-δ expression was highest in H. pylori-positive gastritis patients, specifically in the antrum tissues. miR-9 showed significant downregulation in H. pylori-positive gastritis samples.  Conclusion:: cagA-positive H. pylori infection was linked to distinct gene expression changes that varied by gastric region. Further studies are needed to explore the mechanisms involved.
SN  - 2008-3289
SN  - 2008-4447
ER  -