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Peer-reviewedCC BYJPGN reports

Collagenous gastritis in pediatric patients with severe follicular pangastritis and iron deficiency anemia.

  • María Juliana Rusinque Del Busto1,2
  • Karina Lozano Rivera3
  • Maira Alejandra Forero Rivera4
  • Alejandra Calderón5
  • Santiago Walker6
  • Angie Vergara Espitia1,2
  • José Fernando Vera Chamorro1,2
6 affiliations
  1. 1Universidad de los Andes, Fundación Santa Fe de Bogotá Grupo de investigación PediaFe Bogotá Colombia.
  2. 2Gastroenterología Pediátrica, Fundación Santa Fe de Bogotá Bogotá Colombia.
  3. 3Gastroenterología Pediátrica Universidad El Bosque Bogotá Colombia.
  4. 4Patología Universidad de los Andes Bogotá Colombia.
  5. 5Oncohematología Pediátrica, Fundación Santa Fe de Bogotá Bogotá Colombia.
  6. 6Patología Gastrointestinal, Fundación Santa Fe de Bogotá Bogotá Colombia.
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Abstract

Collagenous gastritis is a rare disorder characterized by subepithelial collagen deposition in the gastric mucosa and is frequently associated with iron deficiency anemia. We report two girls aged 8 and 16 years with persistent iron deficiency anemia, abdominal pain, bloating, and constipation. Upper endoscopy revealed severe follicular pangastritis in both patients. Histopathology demonstrated collagenous gastritis, with subepithelial collagen bands measuring 23 and 18 μm, respectively, accompanied by eosinophilic infiltration and absence of Helicobacter pylori infection. One patient had a history of cow's milk allergy and autoimmune family history, whereas the second had positive celiac serology with negative HLA-DQ2/DQ8. Individualized management included dietary modification, iron replacement, proton pump inhibitor therapy, systemic corticosteroids in one patient, and oral budesonide in the other. Both patients showed clinical improvement and recovery from iron deficiency anemia. These cases highlight collagenous gastritis as an important diagnostic consideration in children and adolescents with refractory iron deficiency anemia and follicular pangastritis.

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Cite

BibTeXRIS
BibTeX
@article{busto2026collagenous,
  title = {{Collagenous gastritis in pediatric patients with severe follicular pangastritis and iron deficiency anemia.}},
  author = {María Juliana Rusinque Del Busto and Karina Lozano Rivera and Maira Alejandra Forero Rivera and Alejandra Calderón and Santiago Walker and Angie Vergara Espitia and José Fernando Vera Chamorro},
  journal = {JPGN reports},
  year = {2026},
  month = oct,
  doi = {10.1002/jpr3.70279},
  url = {https://europepmc.org/article/MED/42953744},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Collagenous gastritis in pediatric patients with severe follicular pangastritis and iron deficiency anemia.
AU  - María Juliana Rusinque Del Busto
AU  - Karina Lozano Rivera
AU  - Maira Alejandra Forero Rivera
AU  - Alejandra Calderón
AU  - Santiago Walker
AU  - Angie Vergara Espitia
AU  - José Fernando Vera Chamorro
PY  - 2026
DA  - 2026/10/28
JO  - JPGN reports
DO  - 10.1002/jpr3.70279
UR  - https://europepmc.org/article/MED/42953744
AB  - Collagenous gastritis is a rare disorder characterized by subepithelial collagen deposition in the gastric mucosa and is frequently associated with iron deficiency anemia. We report two girls aged 8 and 16 years with persistent iron deficiency anemia, abdominal pain, bloating, and constipation. Upper endoscopy revealed severe follicular pangastritis in both patients. Histopathology demonstrated collagenous gastritis, with subepithelial collagen bands measuring 23 and 18 μm, respectively, accompanied by eosinophilic infiltration and absence of Helicobacter pylori infection. One patient had a history of cow's milk allergy and autoimmune family history, whereas the second had positive celiac serology with negative HLA-DQ2/DQ8. Individualized management included dietary modification, iron replacement, proton pump inhibitor therapy, systemic corticosteroids in one patient, and oral budesonide in the other. Both patients showed clinical improvement and recovery from iron deficiency anemia. These cases highlight collagenous gastritis as an important diagnostic consideration in children and adolescents with refractory iron deficiency anemia and follicular pangastritis.
SN  - 2691-171X
ER  -