Hemodynamic Responses to Cold Water Ingestion During Head-Up Tilt
- 1School of Health Sciences at Odawara, International University of Health and Welfare
Abstract
PurposeWe examined whether drinking a small volume of cold water during orthostatic stress attenuates the fall in systolic blood pressure (SBP).
MethodsIn a randomized crossover study, 19 healthy young adults underwent 15 min of 60{degrees} head-up tilt under three conditions on separate days: no water, 200 mL of body-temperature water (37 {degrees}C), and 200 mL of cold water (4 {degrees}C). Drinking began 5 min after tilting and lasted 1 min. Hemodynamics and tympanic temperature were analyzed using covariate-adjusted linear mixed models with within- and between-condition comparisons.
ResultsDuring drinking, SBP increased from pre-drinking values by 9.54 mmHg (95% confidence interval [CI] 5.58 to 13.50) with body-temperature water and 14.70 mmHg (10.74 to 18.66) with cold water. After cold water ingestion, SBP remained higher by 5.95 mmHg (95% CI 1.99 to 9.91) over the first 4 min and 4.84 mmHg (0.88 to 8.80) over the subsequent 5 min. No clear post-drinking increases occurred with body-temperature water. SBP was higher with cold water than with both other conditions during the first 4 min after drinking, and higher than with body-temperature water during the subsequent 5 min. After cold water ingestion, stroke volume was higher and heart rate lower than before drinking, and tympanic temperature declined between the two post-drinking periods.
ConclusionDrinking 200 mL of cold water after blood pressure had fallen attenuated the reduction in SBP during continued orthostatic stress in healthy young adults.
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BibTeX
@misc{kubota2026hemodynamic,
title = {{Hemodynamic Responses to Cold Water Ingestion During Head-Up Tilt}},
author = {S. Kubota and K. Yamauchi and Y. Endo and M. Kubota},
howpublished = {medRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.29.26364369},
url = {https://www.medrxiv.org/content/10.64898/2026.09.29.26364369v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Hemodynamic Responses to Cold Water Ingestion During Head-Up Tilt
AU - S. Kubota
AU - K. Yamauchi
AU - Y. Endo
AU - M. Kubota
PY - 2026
DA - 2026/09/29
PB - medRxiv
DO - 10.64898/2026.09.29.26364369
UR - https://www.medrxiv.org/content/10.64898/2026.09.29.26364369v1
AB - PurposeWe examined whether drinking a small volume of cold water during orthostatic stress attenuates the fall in systolic blood pressure (SBP). MethodsIn a randomized crossover study, 19 healthy young adults underwent 15 min of 60{degrees} head-up tilt under three conditions on separate days: no water, 200 mL of body-temperature water (37 {degrees}C), and 200 mL of cold water (4 {degrees}C). Drinking began 5 min after tilting and lasted 1 min. Hemodynamics and tympanic temperature were analyzed using covariate-adjusted linear mixed models with within- and between-condition comparisons. ResultsDuring drinking, SBP increased from pre-drinking values by 9.54 mmHg (95% confidence interval [CI] 5.58 to 13.50) with body-temperature water and 14.70 mmHg (10.74 to 18.66) with cold water. After cold water ingestion, SBP remained higher by 5.95 mmHg (95% CI 1.99 to 9.91) over the first 4 min and 4.84 mmHg (0.88 to 8.80) over the subsequent 5 min. No clear post-drinking increases occurred with body-temperature water. SBP was higher with cold water than with both other conditions during the first 4 min after drinking, and higher than with body-temperature water during the subsequent 5 min. After cold water ingestion, stroke volume was higher and heart rate lower than before drinking, and tympanic temperature declined between the two post-drinking periods. ConclusionDrinking 200 mL of cold water after blood pressure had fallen attenuated the reduction in SBP during continued orthostatic stress in healthy young adults.
ER -