Skip to content
DraconiticResearch
Search Sources API
186,631 studies31 sourcesUpdated 30 min ago
Peer-reviewedCC BYCureus

Effectiveness of Antenatal Interventions in Preventing Pregnancy-Related Complications: A Systematic Review.

  • Uppalapati Priyanka1
  • Pranjal Upadhayay2
  • Bikash Majumder3
  • Sumit Sukla Das3
  • Narayan Kamath4
  • Darshna Sarvaiya5
  • Nikeeta Ashokrao Khanorkar6,7
7 affiliations
  1. 1Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences (AIIMS), Mangalagiri, Mangalagiri, IND.
  2. 2Department of Public Health and Medical Education, National Medical College and Teaching Hospital, Birgunj, NPL.
  3. 3Department of Obstetrics and Gynaecology, Agartala Government Medical College, Agartala, IND.
  4. 4Department of Microbiology, NAMO Medical Education and Research Institute and NAMO Hospital, Silvassa, IND.
  5. 5Department of Community Medicine, Dr. N.D. Desai Faculty of Medical Science and Research, Dharmsinh Desai University, Nadiad, IND.
  6. 6Department of Obstetrics and Gynaecology, Government Medical College, Nagpur, Nagpur, IND.
  7. 7Department of Obstetrics and Gynaecology, Maharashtra University of Health Sciences, Nashik, IND.
Read full textPDFDOICite

Abstract

Gestational diabetes mellitus, preeclampsia, and other adverse pregnancy outcomes continue to contribute substantially to maternal and neonatal morbidity worldwide. The increasing burden of metabolic and hypertensive complications during pregnancy has strengthened the need for effective, targeted preventive strategies. Although pharmacological, lifestyle, dietary, and healthcare system interventions have been widely studied, their effects vary according to the clinical outcome, population risk profile, intervention intensity, timing, adherence, and healthcare setting. Gaps therefore remain in identifying which approaches provide consistent benefit across different maternal and neonatal outcomes. This review synthesized evidence from randomized controlled trials evaluating interventions intended to improve pregnancy-related outcomes. A structured systematic search and study-selection process was undertaken, and eligible trials included pharmacological, lifestyle, dietary, behavioral, and healthcare system interventions. Data were synthesized qualitatively, and methodological quality and risk of bias were assessed using established criteria. The findings indicate that pharmacological interventions, including aspirin, calcium supplementation, and antenatal corticosteroids, showed benefits for selected outcomes in appropriately defined clinical populations and settings. Lifestyle and dietary interventions showed heterogeneous findings, with structured and intensive approaches demonstrating favorable outcomes in some populations, whereas lower-intensity interventions produced less consistent effects on major clinical endpoints. Behavioral and healthcare system interventions improved selected aspects of care delivery and patient-centered outcomes, although effects on major maternal and neonatal clinical outcomes were less consistent. Overall, the evidence supports targeted, context-specific use of preventive interventions rather than direct ranking of intervention categories, while recognizing substantial heterogeneity across populations, interventions, and outcomes.

Related

  1. Ergonomic Interventions and Technology in Preventing Musculoskeletal Disorders Among Sonographers (2000-2025): A Systematic Mapping Review
    A. B. Akomah, A. D. Piersson, M. W. Tizumah
    medRxivPreprintCC BYFull textMedical imaging & radiologymedRxiv
  2. Effectiveness of dynamic neuromuscular stabilization-based interventions for nonspecific low back pain: a systematic review and meta-analysis
    Yuanyuan Ma, Yonghuan Chen, Jae Chul Seo +3
    Frontiers in medicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC
  3. Comparative effectiveness of exercise and self-management interventions delivered through different modes of digital support on pain and patient-reported physical function in people with knee osteoarthritis: a systematic review and network meta-analysis of randomised controlled trials
    Hao Luo, Guoqing Zhang, Lingyun Long +3
    Frontiers in medicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. Effectiveness of green health prescribing and nature-based interventions in primary care and community settings for older adults: a systematic review of health, wellbeing and social outcomes
    Furqan Butt, Jeremiah Donoghue, Cameron Ley +10
    BMC MedicinePeer-reviewedCC BY-NC-ND 4.0Full textPharmacology & toxicologyCrossref
  5. Maternal and Antenatal Complications in Pregnancies Complicated by Fetal Intra-Abdominal Umbilical Vein Varix
    Journal of clinical medicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{priyanka2026effectiveness,
  title = {{Effectiveness of Antenatal Interventions in Preventing Pregnancy-Related Complications: A Systematic Review.}},
  author = {Uppalapati Priyanka and Pranjal Upadhayay and Bikash Majumder and Sumit Sukla Das and Narayan Kamath and Darshna Sarvaiya and Nikeeta Ashokrao Khanorkar},
  journal = {Cureus},
  year = {2026},
  month = sep,
  doi = {10.7759/cureus.116832},
  url = {https://europepmc.org/article/MED/42927366},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Effectiveness of Antenatal Interventions in Preventing Pregnancy-Related Complications: A Systematic Review.
AU  - Uppalapati Priyanka
AU  - Pranjal Upadhayay
AU  - Bikash Majumder
AU  - Sumit Sukla Das
AU  - Narayan Kamath
AU  - Darshna Sarvaiya
AU  - Nikeeta Ashokrao Khanorkar
PY  - 2026
DA  - 2026/09/24
JO  - Cureus
DO  - 10.7759/cureus.116832
UR  - https://europepmc.org/article/MED/42927366
AB  - Gestational diabetes mellitus, preeclampsia, and other adverse pregnancy outcomes continue to contribute substantially to maternal and neonatal morbidity worldwide. The increasing burden of metabolic and hypertensive complications during pregnancy has strengthened the need for effective, targeted preventive strategies. Although pharmacological, lifestyle, dietary, and healthcare system interventions have been widely studied, their effects vary according to the clinical outcome, population risk profile, intervention intensity, timing, adherence, and healthcare setting. Gaps therefore remain in identifying which approaches provide consistent benefit across different maternal and neonatal outcomes. This review synthesized evidence from randomized controlled trials evaluating interventions intended to improve pregnancy-related outcomes. A structured systematic search and study-selection process was undertaken, and eligible trials included pharmacological, lifestyle, dietary, behavioral, and healthcare system interventions. Data were synthesized qualitatively, and methodological quality and risk of bias were assessed using established criteria. The findings indicate that pharmacological interventions, including aspirin, calcium supplementation, and antenatal corticosteroids, showed benefits for selected outcomes in appropriately defined clinical populations and settings. Lifestyle and dietary interventions showed heterogeneous findings, with structured and intensive approaches demonstrating favorable outcomes in some populations, whereas lower-intensity interventions produced less consistent effects on major clinical endpoints. Behavioral and healthcare system interventions improved selected aspects of care delivery and patient-centered outcomes, although effects on major maternal and neonatal clinical outcomes were less consistent. Overall, the evidence supports targeted, context-specific use of preventive interventions rather than direct ranking of intervention categories, while recognizing substantial heterogeneity across populations, interventions, and outcomes.
SN  - 2168-8184
ER  -