Silver‐Mediated Deuterium Labelling of Quinones and Related Compounds by Hydrogen Isotope Exchange With D 2 O
Abstract
We report a silver‐catalyzed hydrogen isotope exchange reaction that enables direct deuteration of quinones and related scaffolds, using readily available D 2 O as an isotopic source. The homogeneous Ag 2 SO 4 system provides high isotopic enrichment, up to 99%, with excellent regioselectivity across diverse frameworks, including substituted para ‐naphthoquinones, anthraquinones, coumarins, quinolinones, and chromones. We also developed a heterogeneous version of the same reaction by supporting silver nanoparticles on carbon nanotubes. The nanohybrid catalyst maintains high performance and allows for easy removal of the catalyst from the final product through filtration. The dual homogeneous/heterogeneous approaches pioneer quinone hydrogen isotope exchange, providing practical and straightforward access to isotopologues.
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BibTeX
@article{oliveira2026silvermediated,
title = {{Silver‐Mediated Deuterium Labelling of Quinones and Related Compounds by Hydrogen Isotope Exchange With D 2 O}},
author = {Joyce de Oliveira and Mateus Nunes and Frédéric Miserque and Valérie Geertsen and Guilherme Jardim and Eric Doris and Eufrânio Júnior and Edmond Gravel},
journal = {Chemistry - A European Journal},
year = {2026},
month = sep,
doi = {10.1002/chem.71584},
url = {https://hal.science/hal-05742318v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Silver‐Mediated Deuterium Labelling of Quinones and Related Compounds by Hydrogen Isotope Exchange With D 2 O
AU - Joyce de Oliveira
AU - Mateus Nunes
AU - Frédéric Miserque
AU - Valérie Geertsen
AU - Guilherme Jardim
AU - Eric Doris
AU - Eufrânio Júnior
AU - Edmond Gravel
PY - 2026
DA - 2026/09/08
JO - Chemistry - A European Journal
DO - 10.1002/chem.71584
UR - https://hal.science/hal-05742318v1
AB - We report a silver‐catalyzed hydrogen isotope exchange reaction that enables direct deuteration of quinones and related scaffolds, using readily available D 2 O as an isotopic source. The homogeneous Ag 2 SO 4 system provides high isotopic enrichment, up to 99%, with excellent regioselectivity across diverse frameworks, including substituted para ‐naphthoquinones, anthraquinones, coumarins, quinolinones, and chromones. We also developed a heterogeneous version of the same reaction by supporting silver nanoparticles on carbon nanotubes. The nanohybrid catalyst maintains high performance and allows for easy removal of the catalyst from the final product through filtration. The dual homogeneous/heterogeneous approaches pioneer quinone hydrogen isotope exchange, providing practical and straightforward access to isotopologues.
SN - 0947-6539
SN - 1521-3765
ER -