Factors Influencing Older Adults’ Intention to Enroll in an Alzheimer’s Secondary Prevention Trial and to Ask a Study Partner to Enroll with Them: Results from A National Survey
Abstract
INTRODUCTION: One barrier to successful completion of Alzheimer's secondary prevention trials is recruitment of inclusive samples. METHODS: A national survey of U.S. adults ≥ 65 assessed salient beliefs underlying intention to enroll in a hypothetical secondary prevention trial of an investigational drug and, among those somewhat or very likely to enroll, intention to ask a study partner to participate with them. RESULTS: Only 24.4% of respondents indicated that they were likely to enroll in the hypothetical trial. Within the subset of respondents likely to enroll, 61.3% indicated that they were likely to ask a study partner to participate with them. While there were no statistically significant differences in intention to enroll or to ask a partner between Black and White respondents, there were significant differences in the beliefs underlying those intentions. DISCUSSION: Understanding beliefs underlying intention can inform development of evidence-based outreach messages and recruitment approaches to enhance representation.
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BibTeX
@article{largent2026factors,
title = {{Factors Influencing Older Adults’ Intention to Enroll in an Alzheimer’s Secondary Prevention Trial and to Ask a Study Partner to Enroll with Them: Results from A National Survey}},
author = {Emily A. Largent and Joshua D. Grill and Jason Karlawish and Amy Bleakley},
journal = {Alzheimer's \& dementia. Behavior \& socioeconomics of aging},
year = {2026},
month = nov,
doi = {10.1002/bsa3.70122},
url = {https://doi.org/10.1002/bsa3.70122},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Factors Influencing Older Adults’ Intention to Enroll in an Alzheimer’s Secondary Prevention Trial and to Ask a Study Partner to Enroll with Them: Results from A National Survey
AU - Emily A. Largent
AU - Joshua D. Grill
AU - Jason Karlawish
AU - Amy Bleakley
PY - 2026
DA - 2026/11/03
JO - Alzheimer's & dementia. Behavior & socioeconomics of aging
DO - 10.1002/bsa3.70122
UR - https://doi.org/10.1002/bsa3.70122
AB - INTRODUCTION: One barrier to successful completion of Alzheimer's secondary prevention trials is recruitment of inclusive samples. METHODS: A national survey of U.S. adults ≥ 65 assessed salient beliefs underlying intention to enroll in a hypothetical secondary prevention trial of an investigational drug and, among those somewhat or very likely to enroll, intention to ask a study partner to participate with them. RESULTS: Only 24.4% of respondents indicated that they were likely to enroll in the hypothetical trial. Within the subset of respondents likely to enroll, 61.3% indicated that they were likely to ask a study partner to participate with them. While there were no statistically significant differences in intention to enroll or to ask a partner between Black and White respondents, there were significant differences in the beliefs underlying those intentions. DISCUSSION: Understanding beliefs underlying intention can inform development of evidence-based outreach messages and recruitment approaches to enhance representation.
SN - 2997-3805
ER -