Socio-clinical profiles and life satisfaction (LS) in individuals with emerging cognitive disorders (MCI or iSCCs) a multicenter cross-sectional study in French university-affiliated memory clinics
- 1Center for Research in Medicine, Science, Health, Mental Health, and Society CERMES3 (UMR CNRS 8211 - Unité INSERM 988 - EHESS - Université Paris Cité), Villejuif, France
Abstract
Background: Mild cognitive impairment (MCI) and subjective cognitive complaints (SCCs) are risk factors for dementia, with significant human and economic impact. Life satisfaction (LS) remains underexplored across different cognitive profiles.
Objectives: (1) To describe the socio-demographic and clinical characteristics of individuals according to MCI subtype (four groups based on amnestic/non-amnestic and single/multi-domain status) and isolated SCCs (iSCCs); (2) to compare LS between these groups; (3) to identify factors associated with low LS.
Design and Methods: We conducted a cross-sectional analysis of 2,252 participants from the French Memento cohort, recruited in 26 university-affiliated memory clinics. LS was assessed through a standard single-item measure and dichotomised into high vs. low satisfaction. Logistic regression models examined associations with cognitive, clinical, functional, and psychosocial variables.
Results: LS did not differ significantly across cognitive subtypes, despite socio-demographic and clinical differences. In contrast, participants with a Clinical Dementia Rating (CDR) of 0.5 reported lower LS than those with a CDR of 0, highlighting an association between perceived LS and global clinical stage rather than subtype. Main factors associated with low LS included mood disorders, poor self-rated health, perceived lack of freedom, and weak social networks.
Conclusion: In emerging cognitive disorders, LS is influenced more by modifiable psychosocial factors than by cognitive subtype. This highlights the need to strengthen person-centered interventions from earliest stages of cognitive decline – whatever form – with particular focus on mood, sense of autonomy and social connection. Memory clinics (alongside general practitioners) are key in identifying vulnerabilities and providing targeted multidisciplinary support.
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BibTeX
@article{tibilevy2026socioclinical,
title = {{Socio-clinical profiles and life satisfaction (LS) in individuals with emerging cognitive disorders (MCI or iSCCs) a multicenter cross-sectional study in French university-affiliated memory clinics}},
author = {Yaël Tibi-Levy},
journal = {Journal of Public Health Research},
year = {2026},
month = jul,
doi = {10.1177/22799036261487220},
url = {https://europepmc.org/article/PMC/PMC13724926},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Socio-clinical profiles and life satisfaction (LS) in individuals with emerging cognitive disorders (MCI or iSCCs) a multicenter cross-sectional study in French university-affiliated memory clinics
AU - Yaël Tibi-Levy
PY - 2026
DA - 2026/07/01
JO - Journal of Public Health Research
DO - 10.1177/22799036261487220
UR - https://europepmc.org/article/PMC/PMC13724926
AB - Background: Mild cognitive impairment (MCI) and subjective cognitive complaints (SCCs) are risk factors for dementia, with significant human and economic impact. Life satisfaction (LS) remains underexplored across different cognitive profiles. Objectives: (1) To describe the socio-demographic and clinical characteristics of individuals according to MCI subtype (four groups based on amnestic/non-amnestic and single/multi-domain status) and isolated SCCs (iSCCs); (2) to compare LS between these groups; (3) to identify factors associated with low LS. Design and Methods: We conducted a cross-sectional analysis of 2,252 participants from the French Memento cohort, recruited in 26 university-affiliated memory clinics. LS was assessed through a standard single-item measure and dichotomised into high vs. low satisfaction. Logistic regression models examined associations with cognitive, clinical, functional, and psychosocial variables. Results: LS did not differ significantly across cognitive subtypes, despite socio-demographic and clinical differences. In contrast, participants with a Clinical Dementia Rating (CDR) of 0.5 reported lower LS than those with a CDR of 0, highlighting an association between perceived LS and global clinical stage rather than subtype. Main factors associated with low LS included mood disorders, poor self-rated health, perceived lack of freedom, and weak social networks. Conclusion: In emerging cognitive disorders, LS is influenced more by modifiable psychosocial factors than by cognitive subtype. This highlights the need to strengthen person-centered interventions from earliest stages of cognitive decline – whatever form – with particular focus on mood, sense of autonomy and social connection. Memory clinics (alongside general practitioners) are key in identifying vulnerabilities and providing targeted multidisciplinary support.
SN - 2279-9028
SN - 2279-9036
ER -