Chitosan-derived porous magnetic M-NPC/Arg/SO
- 1Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, P. O. Box 8731753153, Kashan, Iran
- 2Corresponding author.
Abstract
This study presents the development of a novel, magnetically recoverable sulfonic acid-functionalized nitrogen-doped porous carbon nanocatalyst derived from well-characterized chitosan extracted from Persian Gulf shrimp shell waste. Chitosan, as the key renewable carbohydrate polymer, was first coated onto cobalt ferrite nanoparticles at optimized loadings, followed by controlled carbonization to form the magnetic nitrogen-doped porous carbon (M-NPC) support. Sequential functionalization with arginine and sulfonic acid groups afforded the highly active heterogeneous solid acid catalyst M-NPC/Arg/SO 3 H. Comprehensive characterization confirmed the crystalline structure, uniform morphology, high surface area, thermal stability, and superparamagnetic behavior of the catalyst, enabling facile magnetic recovery. The catalyst excelled in the green one-pot synthesis of 1,2-disubstituted benzimidazoles under mild conditions, delivering high yields. M-NPC/Arg/SO 3 H showed excellent turnover metrics, negligible metal leaching, and remarkable recyclability. Molecular docking against CXCR4 (PDB: 3ODU) revealed favorable binding to Arg188 and Trp102. Most compounds satisfied Lipinski’s Rule of Five, exhibited excellent predicted oral absorption, high Caco-2 permeability and moderate-to-high CNS activity, positioning them as promising CXCR4 antagonist leads for HIV-1 entry inhibition and cancer metastasis suppression. This integrated approach combines waste valorization of a renewable polysaccharide, sustainable catalysis, green synthesis and virtual screening, offering an eco-friendly platform for drug discovery.
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BibTeX
@article{dehghani2026chitosanderived,
title = {{Chitosan-derived porous magnetic M-NPC/Arg/SO}},
author = {Abdulhamid Dehghani and Leila Moradi},
journal = {Carbohydrate Polymer Technologies and Applications},
year = {2026},
month = oct,
doi = {10.1016/j.carpta.2026.101276},
url = {https://doi.org/10.1016/j.carpta.2026.101276},
note = {CC BY},
}
RIS
TY - JOUR
TI - Chitosan-derived porous magnetic M-NPC/Arg/SO
AU - Abdulhamid Dehghani
AU - Leila Moradi
PY - 2026
DA - 2026/10/30
JO - Carbohydrate Polymer Technologies and Applications
DO - 10.1016/j.carpta.2026.101276
UR - https://doi.org/10.1016/j.carpta.2026.101276
AB - This study presents the development of a novel, magnetically recoverable sulfonic acid-functionalized nitrogen-doped porous carbon nanocatalyst derived from well-characterized chitosan extracted from Persian Gulf shrimp shell waste. Chitosan, as the key renewable carbohydrate polymer, was first coated onto cobalt ferrite nanoparticles at optimized loadings, followed by controlled carbonization to form the magnetic nitrogen-doped porous carbon (M-NPC) support. Sequential functionalization with arginine and sulfonic acid groups afforded the highly active heterogeneous solid acid catalyst M-NPC/Arg/SO 3 H. Comprehensive characterization confirmed the crystalline structure, uniform morphology, high surface area, thermal stability, and superparamagnetic behavior of the catalyst, enabling facile magnetic recovery. The catalyst excelled in the green one-pot synthesis of 1,2-disubstituted benzimidazoles under mild conditions, delivering high yields. M-NPC/Arg/SO 3 H showed excellent turnover metrics, negligible metal leaching, and remarkable recyclability. Molecular docking against CXCR4 (PDB: 3ODU) revealed favorable binding to Arg188 and Trp102. Most compounds satisfied Lipinski’s Rule of Five, exhibited excellent predicted oral absorption, high Caco-2 permeability and moderate-to-high CNS activity, positioning them as promising CXCR4 antagonist leads for HIV-1 entry inhibition and cancer metastasis suppression. This integrated approach combines waste valorization of a renewable polysaccharide, sustainable catalysis, green synthesis and virtual screening, offering an eco-friendly platform for drug discovery.
SN - 2666-8939
ER -