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Peer-reviewedCC BY-NC-ND 4.0Nature Communications

A genetic platform to deconvolve efficacy and toxicity reveals the on-target effects of CDK11 inhibition in vivo

  • Linda Julian
  • Lisa Crozier
  • Devon Lukow
  • Aditi Swamy
  • Sanat Mishra
  • Ryan A. Hagenson
  • Peter Sennhenn
  • Erin L. Sausville
  • Amy J. S. McGeoch
  • Sarah L. Thompson
  • Brianna Mendelson
  • Claudio Chuaqui
26 more authors
  • Lu Qiao
  • Anand Vasudevan
  • Kuan-Ting Lin
  • Sonam Bhatia
  • Thierry Bertomeu
  • Andrew Chatr-aryamontri
  • Li Zhang
  • Matthew G. Rees
  • Melissa M. Ronan
  • Jennifer A. Roth
  • Timothy Nottoli
  • Suxia Bai
  • Jayalakshmi Lakshmipathi
  • Viswanathan Muthusamy
  • Jonathan G. Van Vranken
  • Gregory Gauthier-Coles
  • Steven P. Gygi
  • Joan C. Smith
  • Kendall Anderson
  • Sanjana Shah
  • Ranjit S. Bindra
  • Martin Akerman
  • David L. Spector
  • Basil J. Greber
  • Adrian R. Krainer
  • Jason M. Sheltzer
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Cite

BibTeXRIS
BibTeX
@article{julian2026genetic,
  title = {{A genetic platform to deconvolve efficacy and toxicity reveals the on-target effects of CDK11 inhibition in vivo}},
  author = {Linda Julian and Lisa Crozier and Devon Lukow and Aditi Swamy and Sanat Mishra and Ryan A. Hagenson and Peter Sennhenn and Erin L. Sausville and Amy J. S. McGeoch and Sarah L. Thompson and Brianna Mendelson and Claudio Chuaqui and Lu Qiao and Anand Vasudevan and Kuan-Ting Lin and Sonam Bhatia and Thierry Bertomeu and Andrew Chatr-aryamontri and Li Zhang and Matthew G. Rees and Melissa M. Ronan and Jennifer A. Roth and Timothy Nottoli and Suxia Bai and Jayalakshmi Lakshmipathi and Viswanathan Muthusamy and Jonathan G. Van Vranken and Gregory Gauthier-Coles and Steven P. Gygi and Joan C. Smith and Kendall Anderson and Sanjana Shah and Ranjit S. Bindra and Martin Akerman and David L. Spector and Basil J. Greber and Adrian R. Krainer and Jason M. Sheltzer},
  journal = {Nature Communications},
  year = {2026},
  month = oct,
  doi = {10.1038/s41467-026-78814-0},
  url = {https://www.nature.com/articles/s41467-026-78814-0},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - A genetic platform to deconvolve efficacy and toxicity reveals the on-target effects of CDK11 inhibition in vivo
AU  - Linda Julian
AU  - Lisa Crozier
AU  - Devon Lukow
AU  - Aditi Swamy
AU  - Sanat Mishra
AU  - Ryan A. Hagenson
AU  - Peter Sennhenn
AU  - Erin L. Sausville
AU  - Amy J. S. McGeoch
AU  - Sarah L. Thompson
AU  - Brianna Mendelson
AU  - Claudio Chuaqui
AU  - Lu Qiao
AU  - Anand Vasudevan
AU  - Kuan-Ting Lin
AU  - Sonam Bhatia
AU  - Thierry Bertomeu
AU  - Andrew Chatr-aryamontri
AU  - Li Zhang
AU  - Matthew G. Rees
AU  - Melissa M. Ronan
AU  - Jennifer A. Roth
AU  - Timothy Nottoli
AU  - Suxia Bai
AU  - Jayalakshmi Lakshmipathi
AU  - Viswanathan Muthusamy
AU  - Jonathan G. Van Vranken
AU  - Gregory Gauthier-Coles
AU  - Steven P. Gygi
AU  - Joan C. Smith
AU  - Kendall Anderson
AU  - Sanjana Shah
AU  - Ranjit S. Bindra
AU  - Martin Akerman
AU  - David L. Spector
AU  - Basil J. Greber
AU  - Adrian R. Krainer
AU  - Jason M. Sheltzer
PY  - 2026
DA  - 2026/10/19
JO  - Nature Communications
DO  - 10.1038/s41467-026-78814-0
UR  - https://www.nature.com/articles/s41467-026-78814-0
SN  - 2041-1723
ER  -