Peroxidase-like activity of a POSS-based Cu(I) coordination polymer for colorimetric uric acid detection
Abstract
The design of functional coordination polymers with enzyme-mimicking activity has attracted considerable interest for the development of sensitive, cost-effective sensing platforms. Herein, we report the uric acid sensing properties of a three-dimensional Cu(I)-based coordination polymer constructed from a thioether-functionalized polyhedral oligomeric silsesquioxane (POSS) ligand. The POSS-Cu Coordination polymer (PCCP) exhibits efficient peroxidase-like activity, catalyzing the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by H 2 O 2 to produce a blue product (oxTMB), showing a strong absorption band at 652 nm. Steady-state kinetic studies reveal typical Michaelis-Menten behaviour with low Michaelis constants (K m ) values of 0.166 mM H 2 O 2 and 0.0457 mM for TMB, demonstrating a high affinity toward both substrates. The developed sensing strategy utilizes the reducing ability of UA to convert oxTMB into its colorless form, resulting in a concentration-dependent decrease in absorbance that enables quantitative determination of UA. Under optimized conditions, the colorimetric assay exhibits a linear response with a detection limit of 0.25 μM with excellent repeatability and high selectivity. Moreover, the catalyst retains its catalytic performance over repeated cycles, demonstrating excellent operational stability and making it a promising platform for sensitive, reliable, and cost-effective uric acid analysis.
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BibTeX
@article{mohanty2026peroxidaselike,
title = {{Peroxidase-like activity of a POSS-based Cu(I) coordination polymer for colorimetric uric acid detection}},
author = {Arosmit Mohanty and Anrudh Mishra and Lydie Viau and Michael Knorr and Abhinav Raghuvanshi},
journal = {Microchemical Journal},
year = {2026},
month = oct,
doi = {10.1016/j.microc.2026.120062},
url = {https://hal.science/hal-05847062v1},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Peroxidase-like activity of a POSS-based Cu(I) coordination polymer for colorimetric uric acid detection
AU - Arosmit Mohanty
AU - Anrudh Mishra
AU - Lydie Viau
AU - Michael Knorr
AU - Abhinav Raghuvanshi
PY - 2026
DA - 2026/10/21
JO - Microchemical Journal
DO - 10.1016/j.microc.2026.120062
UR - https://hal.science/hal-05847062v1
AB - The design of functional coordination polymers with enzyme-mimicking activity has attracted considerable interest for the development of sensitive, cost-effective sensing platforms. Herein, we report the uric acid sensing properties of a three-dimensional Cu(I)-based coordination polymer constructed from a thioether-functionalized polyhedral oligomeric silsesquioxane (POSS) ligand. The POSS-Cu Coordination polymer (PCCP) exhibits efficient peroxidase-like activity, catalyzing the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by H 2 O 2 to produce a blue product (oxTMB), showing a strong absorption band at 652 nm. Steady-state kinetic studies reveal typical Michaelis-Menten behaviour with low Michaelis constants (K m ) values of 0.166 mM H 2 O 2 and 0.0457 mM for TMB, demonstrating a high affinity toward both substrates. The developed sensing strategy utilizes the reducing ability of UA to convert oxTMB into its colorless form, resulting in a concentration-dependent decrease in absorbance that enables quantitative determination of UA. Under optimized conditions, the colorimetric assay exhibits a linear response with a detection limit of 0.25 μM with excellent repeatability and high selectivity. Moreover, the catalyst retains its catalytic performance over repeated cycles, demonstrating excellent operational stability and making it a promising platform for sensitive, reliable, and cost-effective uric acid analysis.
SN - 0026-265X
SN - 1095-9149
ER -