Orthogonal functionalization of lithium niobate nanoparticles with targeting aptamers and caged chemotherapeutics
Abstract
amide coupling to yield multifunctional constructs. The colloidal properties of the resulting NPs were assessed by dynamic light scattering (DLS), while drug and aptamer loadings were quantified by the fluorescence emission of the coumarinyl scaffold and Cy5-labelled aptamer, respectively. When SPAAC conjugation was implemented, higher aptamer and drug contents were observed, pointing toward the impact of surface chemistries on the availability of surface reactive handles for downstream functionalization. Overall, this work establishes peptide-coated LNO NPs as a versatile scaffold for the orthogonal anchoring of aptamer and caged therapeutic cargos, paving the way toward decoupled nonlinear optical imaging and light-triggered drug delivery.
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BibTeX
@article{spada2026orthogonal,
title = {{Orthogonal functionalization of lithium niobate nanoparticles with targeting aptamers and caged chemotherapeutics}},
author = {Alessandra Spada and Adrian Gheata and Ameni Dhouib and Yannick Mugnier and Sandrine Gerber-Lemaire},
journal = {RSC Applied Interfaces},
year = {2026},
month = aug,
doi = {10.1039/d6lf00132g},
url = {https://hal.science/hal-05769946v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Orthogonal functionalization of lithium niobate nanoparticles with targeting aptamers and caged chemotherapeutics
AU - Alessandra Spada
AU - Adrian Gheata
AU - Ameni Dhouib
AU - Yannick Mugnier
AU - Sandrine Gerber-Lemaire
PY - 2026
DA - 2026/08/13
JO - RSC Applied Interfaces
DO - 10.1039/d6lf00132g
UR - https://hal.science/hal-05769946v1
AB - amide coupling to yield multifunctional constructs. The colloidal properties of the resulting NPs were assessed by dynamic light scattering (DLS), while drug and aptamer loadings were quantified by the fluorescence emission of the coumarinyl scaffold and Cy5-labelled aptamer, respectively. When SPAAC conjugation was implemented, higher aptamer and drug contents were observed, pointing toward the impact of surface chemistries on the availability of surface reactive handles for downstream functionalization. Overall, this work establishes peptide-coated LNO NPs as a versatile scaffold for the orthogonal anchoring of aptamer and caged therapeutic cargos, paving the way toward decoupled nonlinear optical imaging and light-triggered drug delivery.
SN - 2755-3701
ER -