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Peer-reviewedCC BYRSC advances

Click-chemistry targeting of inflammation using NIR-emitting lanthanide nanoparticles with preserved optical functionality

  • Livia Didonè1
  • Dongmei Qiu2,3
  • Paula Gutiérrez González2
  • Marta Román-Carmena1
  • Emma Martín Rodríguez4,5,6,7
  • Jorge Rubio Retama2,7
  • M. Carmen Iglesias-de la Cruz1,7
  • Dirk H. Ortgies3,5,6,7
  • Daniel Jaque3,5,6,7
  • Miriam Granado1,7
  • Álvaro Artiga3
7 affiliations
  1. 1Nanomaterials for BioImaging Group (nanoBIG), Faculty of Medicine, Department of Physiology, Universidad Autónoma de Madrid 28029 Madrid Spain
  2. 2Department of Chemistry in Pharmaceutical Sciences, Complutense University of Madrid E-28040 Madrid Spain
  3. 3Nanomaterials for BioImaging Group (nanoBIG), Faculty of Science, Department of Materials Physics, Universidad Autónoma de Madrid 28049 Madrid Spain
  4. 4Nanomaterials for BioImaging Group (nanoBIG), Faculty of Science, Department of Applied Physics, Universidad Autónoma de Madrid 28049 Madrid Spain
  5. 5Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid 28049 Madrid Spain
  6. 6Instituto de Ciencia de Materiales Nicolás Cabrera, Universidad Autónoma de Madrid 28049 Madrid Spain
  7. 7Nanomaterials for BioImaging Group, Instituto Ramón y Cajal de, Investigación Sanitaria IRYCIS Ctra de Colmenar km 9300 28034 Madrid Spain
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Abstract

Bioorthogonal click chemistry was employed for the selective detection of VCAM-1 overexpression on inflamed endothelial cells using lanthanide-doped nanoparticles as near-infrared (NIR) probes. Neodymium/Ytterbium co-doped nanoparticles exhibited efficient and specific targeting following bioorthogonal conjugation, while preserving their characteristic NIR emission profile and thermal sensing capabilities. These results demonstrate the potential of this strategy for the selective recognition of inflammatory biomarkers without compromising the optical performance of the nanoprobes, paving the way for multifunctional platforms for inflammation imaging and nanothermometry.

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Cite

BibTeXRIS
BibTeX
@article{didone2026clickchemistry,
  title = {{Click-chemistry targeting of inflammation using NIR-emitting lanthanide nanoparticles with preserved optical functionality}},
  author = {Livia Didonè and Dongmei Qiu and Paula Gutiérrez González and Marta Román-Carmena and Emma Martín Rodríguez and Jorge Rubio Retama and M. Carmen Iglesias-de la Cruz and Dirk H. Ortgies and Daniel Jaque and Miriam Granado and Álvaro Artiga},
  journal = {RSC advances},
  year = {2026},
  month = nov,
  doi = {10.1039/d6ra06790e},
  url = {https://europepmc.org/article/PMC/PMC13730391},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Click-chemistry targeting of inflammation using NIR-emitting lanthanide nanoparticles with preserved optical functionality
AU  - Livia Didonè
AU  - Dongmei Qiu
AU  - Paula Gutiérrez González
AU  - Marta Román-Carmena
AU  - Emma Martín Rodríguez
AU  - Jorge Rubio Retama
AU  - M. Carmen Iglesias-de la Cruz
AU  - Dirk H. Ortgies
AU  - Daniel Jaque
AU  - Miriam Granado
AU  - Álvaro Artiga
PY  - 2026
DA  - 2026/11/03
JO  - RSC advances
DO  - 10.1039/d6ra06790e
UR  - https://europepmc.org/article/PMC/PMC13730391
AB  - Bioorthogonal click chemistry was employed for the selective detection of VCAM-1 overexpression on inflamed endothelial cells using lanthanide-doped nanoparticles as near-infrared (NIR) probes. Neodymium/Ytterbium co-doped nanoparticles exhibited efficient and specific targeting following bioorthogonal conjugation, while preserving their characteristic NIR emission profile and thermal sensing capabilities. These results demonstrate the potential of this strategy for the selective recognition of inflammatory biomarkers without compromising the optical performance of the nanoprobes, paving the way for multifunctional platforms for inflammation imaging and nanothermometry.
SN  - 2046-2069
ER  -