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PreprintCC BY-NC-NDbioRxiv

Oligodendrocyte precursor cell death does not contribute to lifelong population homeostasis

  • Y. Kamen
  • A. Scholand
  • R. A. Hill1
  1. 1Dartmouth College
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Abstract

Oligodendrocyte precursor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes throughout life, but it is unclear if their continuous self-renewal is balanced by cell death. We find that OPCs do not die during development or adulthood, nor during remyelination, acute systemic inflammation, or aging. These findings challenge the assumption that spontaneous OPC death is common and reveal that OPC homeostasis does not depend on programmed cell death.

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Cite

BibTeXRIS
BibTeX
@misc{kamen2026oligodendrocyte,
  title = {{Oligodendrocyte precursor cell death does not contribute to lifelong population homeostasis}},
  author = {Y. Kamen and A. Scholand and R. A. Hill},
  howpublished = {bioRxiv},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.28.762467},
  url = {https://www.biorxiv.org/content/10.64898/2026.10.28.762467v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - UNPB
TI  - Oligodendrocyte precursor cell death does not contribute to lifelong population homeostasis
AU  - Y. Kamen
AU  - A. Scholand
AU  - R. A. Hill
PY  - 2026
DA  - 2026/10/28
PB  - bioRxiv
DO  - 10.64898/2026.10.28.762467
UR  - https://www.biorxiv.org/content/10.64898/2026.10.28.762467v1
AB  - Oligodendrocyte precursor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes throughout life, but it is unclear if their continuous self-renewal is balanced by cell death. We find that OPCs do not die during development or adulthood, nor during remyelination, acute systemic inflammation, or aging. These findings challenge the assumption that spontaneous OPC death is common and reveal that OPC homeostasis does not depend on programmed cell death.
ER  -