Contribution of cohesins STAG1 and STAG2 to preimplantation development in mice
- 1Chromosome Dynamics Group, Spanish National Cancer Research Centre (CNIO)
- 2Mouse Genome Editing Unit, Spanish National Cancer Research Centre (CNIO)
Abstract
Cohesin complexes carrying either STAG1 or STAG2 display functional specificities in both cohesion and genome organization. While any variant is sufficient for cell viability, both are essential for murine embryonic development, and mutations in STAG1 and STAG2 are associated to human syndromes. The requirements and regulation of the cohesin variants in the first stages of development remain unknown. Here, we show that Stag1 and Stag2 gene products are stored in oocytes. Maternal STAG1 persists beyond the 2-cell stage while accumulation of STAG2 depends on zygotic transcription. Despite clear differences in STAG1:STAG2 ratio in the two lineages emerging from the first cell-fate decision, both maternal and zygotic STAG1 and STAG2 are dispensable for viability in preimplantation stages if the other variant is present. However, the absence of STAG2 increases DNA damage in zygotes and affects transcription in blastocysts. These early-stage alterations may contribute to defects leading to embryo lethality by mid-gestation.
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BibTeX
@article{soleferran2026contribution,
title = {{Contribution of cohesins STAG1 and STAG2 to preimplantation development in mice}},
author = {Maria Solé-Ferran and Maria José Andreu and Daniel Giménez-Llorente and Jaime Muñoz and Sagrario Ortega and Ana Losada},
journal = {Communications Biology},
year = {2026},
month = jul,
doi = {10.1038/s42003-026-10665-3},
url = {https://doi.org/10.1038/s42003-026-10665-3},
note = {CC BY},
}
RIS
TY - JOUR
TI - Contribution of cohesins STAG1 and STAG2 to preimplantation development in mice
AU - Maria Solé-Ferran
AU - Maria José Andreu
AU - Daniel Giménez-Llorente
AU - Jaime Muñoz
AU - Sagrario Ortega
AU - Ana Losada
PY - 2026
DA - 2026/07/01
JO - Communications Biology
DO - 10.1038/s42003-026-10665-3
UR - https://doi.org/10.1038/s42003-026-10665-3
AB - Cohesin complexes carrying either STAG1 or STAG2 display functional specificities in both cohesion and genome organization. While any variant is sufficient for cell viability, both are essential for murine embryonic development, and mutations in STAG1 and STAG2 are associated to human syndromes. The requirements and regulation of the cohesin variants in the first stages of development remain unknown. Here, we show that Stag1 and Stag2 gene products are stored in oocytes. Maternal STAG1 persists beyond the 2-cell stage while accumulation of STAG2 depends on zygotic transcription. Despite clear differences in STAG1:STAG2 ratio in the two lineages emerging from the first cell-fate decision, both maternal and zygotic STAG1 and STAG2 are dispensable for viability in preimplantation stages if the other variant is present. However, the absence of STAG2 increases DNA damage in zygotes and affects transcription in blastocysts. These early-stage alterations may contribute to defects leading to embryo lethality by mid-gestation.
SN - 2399-3642
ER -