Visible-light-driven synthesis of quinazoline derivatives using a recyclable CuO/TiO2 nanocomposite photocatalyst
- 1Department of New Materials, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology P.O. Box 76315-117 Kerman Iran [email protected] +98 3426226617 +98 3426226611-12.
- 2Department of Chemistry, Faculty of Science, University of Jiroft P.O. Box 8767161167 Jiroft Iran [email protected] +98-344-334-7061 +98-344-334-7065.
Abstract
A visible-light-driven photocatalytic protocol was developed for the synthesis of diverse quinazoline derivatives using a recyclable CuO/TiO₂ nanocomposite as a heterogeneous catalyst. Characterization by XRD, FT-IR, FE-SEM, and UV-Vis DRS confirmed the successful fabrication of the composite with enhanced visible-light absorption. Under blue-LED irradiation and ambient air, the CuO/TiO₂ catalyst effectively mediated the cascade oxidation of 2-aminobenzyl alcohol to 2-aminobenzaldehyde, followed by condensation with benzaldehydes and an ammonia source to afford a broad scope of quinazolines in good to excellent isolated yields (89-96%). Radical-trapping experiments demonstrated that superoxide radical species (O₂˙⁻) and photogenerated holes (h⁺) play pivotal roles in the catalytic transformation. Furthermore, the catalyst exhibited good operational stability and could be recycled over multiple consecutive cycles without significant loss of catalytic activity.
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BibTeX
@article{hoseinshahi2026visiblelightdriven,
title = {{Visible-light-driven synthesis of quinazoline derivatives using a recyclable CuO/TiO2 nanocomposite photocatalyst}},
author = {Danial Zand Hoseinshahi and Asadollah Hassankhani and Ali Akbari and Batoul Lashkari},
journal = {RSC advances},
year = {2026},
month = nov,
doi = {10.1039/d6ra09408b},
url = {https://europepmc.org/article/PMC/PMC13725858},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Visible-light-driven synthesis of quinazoline derivatives using a recyclable CuO/TiO2 nanocomposite photocatalyst
AU - Danial Zand Hoseinshahi
AU - Asadollah Hassankhani
AU - Ali Akbari
AU - Batoul Lashkari
PY - 2026
DA - 2026/11/02
JO - RSC advances
DO - 10.1039/d6ra09408b
UR - https://europepmc.org/article/PMC/PMC13725858
AB - A visible-light-driven photocatalytic protocol was developed for the synthesis of diverse quinazoline derivatives using a recyclable CuO/TiO₂ nanocomposite as a heterogeneous catalyst. Characterization by XRD, FT-IR, FE-SEM, and UV-Vis DRS confirmed the successful fabrication of the composite with enhanced visible-light absorption. Under blue-LED irradiation and ambient air, the CuO/TiO₂ catalyst effectively mediated the cascade oxidation of 2-aminobenzyl alcohol to 2-aminobenzaldehyde, followed by condensation with benzaldehydes and an ammonia source to afford a broad scope of quinazolines in good to excellent isolated yields (89-96%). Radical-trapping experiments demonstrated that superoxide radical species (O₂˙⁻) and photogenerated holes (h⁺) play pivotal roles in the catalytic transformation. Furthermore, the catalyst exhibited good operational stability and could be recycled over multiple consecutive cycles without significant loss of catalytic activity.
SN - 2046-2069
ER -