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Peer-reviewedCC BYRSC advances

Glutathione-functionalized PVC for hydrogen-bonding assisted fluorescein adsorption and radical scavenging

  • Alessio Giove1
  • Amar Raj1,2
  • Nihal Chelampetty Para1
  • Matti Haukka1
  1. 1University of Jyväskylä, Department of Chemistry 40014 Jyväskylä Finland
  2. 2University of Jyväskylä Nanoscience Center 40014 Jyväskylä Finland
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Abstract

The protection of aquatic ecosystems from the rising discharge of hazardous industrial dyes is a critical challenge for global environmental sustainability. In this context, a glutathione-functionalized polyvinyl chloride (PVC-GSH) adsorbent was synthesized via a nucleophilic substitution reaction and primarily evaluated for the removal of fluorescein. The integration of the GSH moieties into PVC backbone was confirmed by FTIR and 13C CPMAS NMR spectroscopies, complemented by morphological and thermal characterizations (SEM, BET, DSC, and TGA). The resulting PVC-GSH exhibited high selectivity for fluorescein and a rapid optical response, as evidenced by UV-vis and TRFE spectroscopies. Notably, PVC-GSH achieved a fluorescein uptake of ∼97 mg g−1 (highest experimentally observed) at pH 6.0, with equilibrium data best described by an empirical Freundlich model. TRFE measurements demonstrated a rapid signal response on a timescale of ∼3 s. Post-adsorption analysis through FTIR and XPS indicated that binding likely occurs via hydrogen bonding mediated by the GSH moieties, with possible contributions from secondary non-covalent interactions. Beyond its dye remediation capabilities, this novel material showed radical-scavenging activity, yielding a DPPH radical scavenging EC50 of 774 mg L−1. These results highlight PVC-GSH as a dual-function material combining rapid fluorescein uptake with antioxidant properties, and as a potential route for PVC upcycling.

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Cite

BibTeXRIS
BibTeX
@article{giove2026glutathionefunctionalized,
  title = {{Glutathione-functionalized PVC for hydrogen-bonding assisted fluorescein adsorption and radical scavenging}},
  author = {Alessio Giove and Amar Raj and Nihal Chelampetty Para and Matti Haukka},
  journal = {RSC advances},
  year = {2026},
  month = oct,
  doi = {10.1039/d6ra07765j},
  url = {https://europepmc.org/article/PMC/PMC13721795},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Glutathione-functionalized PVC for hydrogen-bonding assisted fluorescein adsorption and radical scavenging
AU  - Alessio Giove
AU  - Amar Raj
AU  - Nihal Chelampetty Para
AU  - Matti Haukka
PY  - 2026
DA  - 2026/10/30
JO  - RSC advances
DO  - 10.1039/d6ra07765j
UR  - https://europepmc.org/article/PMC/PMC13721795
AB  - The protection of aquatic ecosystems from the rising discharge of hazardous industrial dyes is a critical challenge for global environmental sustainability. In this context, a glutathione-functionalized polyvinyl chloride (PVC-GSH) adsorbent was synthesized via a nucleophilic substitution reaction and primarily evaluated for the removal of fluorescein. The integration of the GSH moieties into PVC backbone was confirmed by FTIR and 13C CPMAS NMR spectroscopies, complemented by morphological and thermal characterizations (SEM, BET, DSC, and TGA). The resulting PVC-GSH exhibited high selectivity for fluorescein and a rapid optical response, as evidenced by UV-vis and TRFE spectroscopies. Notably, PVC-GSH achieved a fluorescein uptake of ∼97 mg g−1 (highest experimentally observed) at pH 6.0, with equilibrium data best described by an empirical Freundlich model. TRFE measurements demonstrated a rapid signal response on a timescale of ∼3 s. Post-adsorption analysis through FTIR and XPS indicated that binding likely occurs via hydrogen bonding mediated by the GSH moieties, with possible contributions from secondary non-covalent interactions. Beyond its dye remediation capabilities, this novel material showed radical-scavenging activity, yielding a DPPH radical scavenging EC50 of 774 mg L−1. These results highlight PVC-GSH as a dual-function material combining rapid fluorescein uptake with antioxidant properties, and as a potential route for PVC upcycling.
SN  - 2046-2069
ER  -