Multi-omic Characterization of the Oral Ecosystem and Assessment of Dental Health and Dental Hygiene Metadata in the Participants from a Large Randomized Double-Blinded Clinical Study
- 1Primal Health LLC
Abstract
Increasing evidence highlights the important role the oral ecosystem plays in systemic health. Despite the fact that oral diseases affect nearly 3.5 billion people globally, our understanding of the precise drivers of these diseases remains limited. To bridge this gap and provide broader understanding of oral public health, a clinical study involving 595 participants 20-78 years of age was conducted over 8 weeks. Characterization of the oral ecosystem using metabolomics, metagenomics, and targeted immune markers were analyzed in conjunction with demographic, lifestyle, and medical history metadata. This comprehensive approach allowed for the identification of specific links between microbial and metabolic signatures and overall wellness, providing a contemporary baseline to enable the development of personalized prevention and treatment strategies to help safeguard oral and systemic public health.
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BibTeX
@misc{moglowsky2026multiomic,
title = {{Multi-omic Characterization of the Oral Ecosystem and Assessment of Dental Health and Dental Hygiene Metadata in the Participants from a Large Randomized Double-Blinded Clinical Study}},
author = {H. Moglowsky and S. Ringold and R. Jones and N. Wall and A. Gudjonsson and T. Gravert and J. M. Moll and A. ODonnell and K. Lee and E. Stein},
howpublished = {medRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.24.26363963},
url = {https://www.medrxiv.org/content/10.64898/2026.09.24.26363963v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - Multi-omic Characterization of the Oral Ecosystem and Assessment of Dental Health and Dental Hygiene Metadata in the Participants from a Large Randomized Double-Blinded Clinical Study
AU - H. Moglowsky
AU - S. Ringold
AU - R. Jones
AU - N. Wall
AU - A. Gudjonsson
AU - T. Gravert
AU - J. M. Moll
AU - A. ODonnell
AU - K. Lee
AU - E. Stein
PY - 2026
DA - 2026/09/24
PB - medRxiv
DO - 10.64898/2026.09.24.26363963
UR - https://www.medrxiv.org/content/10.64898/2026.09.24.26363963v1
AB - Increasing evidence highlights the important role the oral ecosystem plays in systemic health. Despite the fact that oral diseases affect nearly 3.5 billion people globally, our understanding of the precise drivers of these diseases remains limited. To bridge this gap and provide broader understanding of oral public health, a clinical study involving 595 participants 20-78 years of age was conducted over 8 weeks. Characterization of the oral ecosystem using metabolomics, metagenomics, and targeted immune markers were analyzed in conjunction with demographic, lifestyle, and medical history metadata. This comprehensive approach allowed for the identification of specific links between microbial and metabolic signatures and overall wellness, providing a contemporary baseline to enable the development of personalized prevention and treatment strategies to help safeguard oral and systemic public health.
ER -