Colonic Metastases from Lung Adenocarcinoma Detected During an Evaluation of Recurrent Diarrhea Associated with Immune-Related Colitis
Abstract
A 74-year-old man with advanced lung adenocarcinoma developed grade 3 diarrhea after treatment with pembrolizumab. Colonoscopy and a biopsy initially suggested immune-related adverse event colitis (irAE colitis), and the symptoms improved with corticosteroid therapy. However, grade 3 diarrhea recurred during prednisolone tapering, raising a suspicion of recurrent colitis. Radiological progression of the associated intra-abdominal lymphadenopathy was also observed. Repeat colonoscopy before infliximab administration revealed multiple colonic metastases from lung adenocarcinoma. Gastrointestinal metastases should be considered in patients with atypical clinical or radiological findings, and repeated endoscopic evaluations may be useful before escalating immunosuppressive therapy.
Related
- PemToxTrial: An Observational Study of PEMetrexed-Associated Severe HematoTOXicity in Lung Adenocarcinoma with Bone Metastases
- Contralateral Axillary Lymph Node Metastases Detected by Repeat Sentinel Lymph Node Biopsy in a Patient with Ipsilateral Breast Tumor Recurrence: A Case Report.
- Lung Metastases of Pancreatic Adenocarcinoma Masquerading as Temporary Improvement of Bilateral Diffuse Lung Opacities Following Treatment for Interstitial Lung Disease.
- A highly successful case report: a patient with intestinal hepatoid adenocarcinoma and liver metastases achieves excellent efficacy following immune-targeted therapy
- Early disease control with a biochemical response to aumolertinib after postoperative recurrence of EGFR-Mutant stage IIIA lung adenocarcinoma after icotinib, with EGFR T790M detected at recurrence: a Case Report
BibTeX
@article{hashimoto2026colonic,
title = {{Colonic Metastases from Lung Adenocarcinoma Detected During an Evaluation of Recurrent Diarrhea Associated with Immune-Related Colitis}},
author = {Naohito Hashimoto and Yoshiaki Nagai and Konjo Cho and Hitomi Watanabe and Kyosuke Kasaoka and Takeshi Asato and Sanehiro Yogi and Susumu Yamazaki and Mai Matsumura and Hidetoshi Nakamura},
journal = {Internal Medicine},
year = {2026},
month = sep,
doi = {10.2169/internalmedicine.8124-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8124-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Colonic Metastases from Lung Adenocarcinoma Detected During an Evaluation of Recurrent Diarrhea Associated with Immune-Related Colitis
AU - Naohito Hashimoto
AU - Yoshiaki Nagai
AU - Konjo Cho
AU - Hitomi Watanabe
AU - Kyosuke Kasaoka
AU - Takeshi Asato
AU - Sanehiro Yogi
AU - Susumu Yamazaki
AU - Mai Matsumura
AU - Hidetoshi Nakamura
PY - 2026
DA - 2026/09/15
JO - Internal Medicine
DO - 10.2169/internalmedicine.8124-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8124-26/_article
AB - A 74-year-old man with advanced lung adenocarcinoma developed grade 3 diarrhea after treatment with pembrolizumab. Colonoscopy and a biopsy initially suggested immune-related adverse event colitis (irAE colitis), and the symptoms improved with corticosteroid therapy. However, grade 3 diarrhea recurred during prednisolone tapering, raising a suspicion of recurrent colitis. Radiological progression of the associated intra-abdominal lymphadenopathy was also observed. Repeat colonoscopy before infliximab administration revealed multiple colonic metastases from lung adenocarcinoma. Gastrointestinal metastases should be considered in patients with atypical clinical or radiological findings, and repeated endoscopic evaluations may be useful before escalating immunosuppressive therapy.
SN - 1349-7235
SN - 0918-2918
ER -