Electrospun Core–Shell Bioadhesive Nanofiber Sheets Enable Durable Pulmonary Air Leak Sealing Under Wet and Dynamic Conditions
4 affiliations
- 1Department of Anatomy Aichi Medical University Nagakute Aichi Japan
- 2Food & Healthcare Incubation Department Mitsubishi Chemical Corporation Chiyoda Tokyo Japan
- 3Laboratory of Nanofiber Technology Gifu Pharmaceutical University Gifu Japan
- 4Laboratory of Pharmaceutical Engineering Gifu Pharmaceutical University Gifu Japan
Abstract
Pulmonary air leak is the most common complication following lung surgery. Most materials used for pulmonary fistula closure rely on fibrin network‐mediated adhesion. However, on the moist and dynamically deforming lung surface, these materials often fail to provide sufficient adhesion, and postoperative air leaks remain a major clinical concern. Since these materials are biologically derived, concerns regarding biosafety risks and high production costs persist. To address these limitations, this study develops a novel closure material that integrates biocompatibility, pressure resistance, tissue adhesion, and seal retention under wet conditions. The closure material is fabricated as a nanofiber sheet via electrospinning. Comparative evaluation of different structural designs demonstrates that incorporating a core–shell nanofiber structure achieves a favorable balance of pressure resistance, tissue adhesion, and seal retention under wet conditions. Acute leak closure was evaluated in five animals, and long‐term safety was assessed in three animals followed for 1 month. The mean air leak volume decreased from 46.2 to 1.8 mL/min, with post‐treatment air leak volumes below the clinically accepted threshold (≤ 10 mL/min) in all five animals. No treatment‐related complications were observed during the follow‐up period. Thus, electrospun nanofiber sheets represent a promising and biosafe approach for pulmonary air leak closure.
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BibTeX
@article{okubo2026electrospun,
title = {{Electrospun Core–Shell Bioadhesive Nanofiber Sheets Enable Durable Pulmonary Air Leak Sealing Under Wet and Dynamic Conditions}},
author = {Tomohito Okubo and Kouji Hara and Naoyuki Hatayama and Kota Takahashi and Eriko Yamazoe and Takaaki Ito and Takao Takeuchi and Yoko Koide and Mayumi Yamada and Munekazu Naito and Kohei Tahara},
journal = {Advanced Healthcare Materials},
year = {2026},
month = oct,
doi = {10.1002/adhm.71789},
url = {https://doi.org/10.1002/adhm.71789},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Electrospun Core–Shell Bioadhesive Nanofiber Sheets Enable Durable Pulmonary Air Leak Sealing Under Wet and Dynamic Conditions
AU - Tomohito Okubo
AU - Kouji Hara
AU - Naoyuki Hatayama
AU - Kota Takahashi
AU - Eriko Yamazoe
AU - Takaaki Ito
AU - Takao Takeuchi
AU - Yoko Koide
AU - Mayumi Yamada
AU - Munekazu Naito
AU - Kohei Tahara
PY - 2026
DA - 2026/10/08
JO - Advanced Healthcare Materials
DO - 10.1002/adhm.71789
UR - https://doi.org/10.1002/adhm.71789
AB - Pulmonary air leak is the most common complication following lung surgery. Most materials used for pulmonary fistula closure rely on fibrin network‐mediated adhesion. However, on the moist and dynamically deforming lung surface, these materials often fail to provide sufficient adhesion, and postoperative air leaks remain a major clinical concern. Since these materials are biologically derived, concerns regarding biosafety risks and high production costs persist. To address these limitations, this study develops a novel closure material that integrates biocompatibility, pressure resistance, tissue adhesion, and seal retention under wet conditions. The closure material is fabricated as a nanofiber sheet via electrospinning. Comparative evaluation of different structural designs demonstrates that incorporating a core–shell nanofiber structure achieves a favorable balance of pressure resistance, tissue adhesion, and seal retention under wet conditions. Acute leak closure was evaluated in five animals, and long‐term safety was assessed in three animals followed for 1 month. The mean air leak volume decreased from 46.2 to 1.8 mL/min, with post‐treatment air leak volumes below the clinically accepted threshold (≤ 10 mL/min) in all five animals. No treatment‐related complications were observed during the follow‐up period. Thus, electrospun nanofiber sheets represent a promising and biosafe approach for pulmonary air leak closure.
SN - 2192-2640
SN - 2192-2659
ER -