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Peer-reviewedCC BY-NC-NDStem cell research & therapy

Stem cell-assisted aligned electrospun nanofiber scaffold for tissue engineering: development to application.

  • Jing Zhao1,2
  • Huanmei Jing1,2
  • Na Liu1,2
  • Yaomu Jiang3
  • Liyun Chen1,2
  • Min Yang1,2
  • Jinxian Wu1,2
  • Bo Liu4
  • Wancong Zhang5,6
  • Shijie Tang7,8
8 affiliations
  1. 1Department of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, Shantou, 515041, Guangdong, China.
  2. 2Shantou Plastic Surgery Clinical Research Center, Plastic Surgery Institute of Shantou University Medical College, Shantou, 515041, Guangdong, China.
  3. 3Department of Dermatology, Second Affiliated Hospital, Shantou University Medical College, Shantou, 515041, Guangdong, China.
  4. 4Chemistry and Chemical Engineering Guangdong Laboratory, Shantou, 515031, China. [email protected].
  5. 5Department of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, Shantou, 515041, Guangdong, China. [email protected].
  6. 6Shantou Plastic Surgery Clinical Research Center, Plastic Surgery Institute of Shantou University Medical College, Shantou, 515041, Guangdong, China. [email protected].
  7. 7Department of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, Shantou, 515041, Guangdong, China. [email protected].
  8. 8Shantou Plastic Surgery Clinical Research Center, Plastic Surgery Institute of Shantou University Medical College, Shantou, 515041, Guangdong, China. [email protected].
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Abstract

Human tissues and organs exhibit limited regenerative capacity; thus, tissue engineering (TE) and regenerative medicine aim to repair damaged tissues and restore their function. TE achieves in situ tissue regeneration through the integration of cells, biomaterial scaffolds, and signaling molecules. Electrospun nanofibers serve as ideal TE scaffolds due to their large surface area and porosity. Aligned electrospun fiber (AESF) scaffolds are used as stem cell carriers for tissue reconstruction because of their extracellular matrix mimetic structures of anisotropic tissues, such as nerves and tendons. Stem cells are the preferred seed cells for TE due to their multidirectional differentiation, microenvironmental regulation, and paracrine cytokine production abilities. This review outlines the aligned electrospinning principles, parameters, strategies, and material selection for stem cell-assisted AESF scaffolds. Following, the types of stem cells, strategies for incorporating stem cells into scaffolds, and the mechanisms by which AESFs regulate stem cell behavior are briefly described. Finally, applications of stem cell-assisted AESF scaffolds in TE are explored. The review concludes by emerging applications of stem cell-assisted AESF scaffolds in TE, discussing current limitations, and potential future directions.

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Cite

BibTeXRIS
BibTeX
@article{zhao2026stem,
  title = {{Stem cell-assisted aligned electrospun nanofiber scaffold for tissue engineering: development to application.}},
  author = {Jing Zhao and Huanmei Jing and Na Liu and Yaomu Jiang and Liyun Chen and Min Yang and Jinxian Wu and Bo Liu and Wancong Zhang and Shijie Tang},
  journal = {Stem cell research \& therapy},
  year = {2026},
  month = aug,
  doi = {10.1186/s13287-026-05201-3},
  url = {https://europepmc.org/article/MED/42972423},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Stem cell-assisted aligned electrospun nanofiber scaffold for tissue engineering: development to application.
AU  - Jing Zhao
AU  - Huanmei Jing
AU  - Na Liu
AU  - Yaomu Jiang
AU  - Liyun Chen
AU  - Min Yang
AU  - Jinxian Wu
AU  - Bo Liu
AU  - Wancong Zhang
AU  - Shijie Tang
PY  - 2026
DA  - 2026/08/01
JO  - Stem cell research & therapy
DO  - 10.1186/s13287-026-05201-3
UR  - https://europepmc.org/article/MED/42972423
AB  - Human tissues and organs exhibit limited regenerative capacity; thus, tissue engineering (TE) and regenerative medicine aim to repair damaged tissues and restore their function. TE achieves in situ tissue regeneration through the integration of cells, biomaterial scaffolds, and signaling molecules. Electrospun nanofibers serve as ideal TE scaffolds due to their large surface area and porosity. Aligned electrospun fiber (AESF) scaffolds are used as stem cell carriers for tissue reconstruction because of their extracellular matrix mimetic structures of anisotropic tissues, such as nerves and tendons. Stem cells are the preferred seed cells for TE due to their multidirectional differentiation, microenvironmental regulation, and paracrine cytokine production abilities. This review outlines the aligned electrospinning principles, parameters, strategies, and material selection for stem cell-assisted AESF scaffolds. Following, the types of stem cells, strategies for incorporating stem cells into scaffolds, and the mechanisms by which AESFs regulate stem cell behavior are briefly described. Finally, applications of stem cell-assisted AESF scaffolds in TE are explored. The review concludes by emerging applications of stem cell-assisted AESF scaffolds in TE, discussing current limitations, and potential future directions.
SN  - 1757-6512
ER  -