A combination of biopsy using eyeMAX and ERCP for the definitive diagnosis of intraductal papillary mucinous neoplasm: A case report.
- 1Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, P.R. China.
Abstract
As a well-established precursor lesion of pancreatic cancer, intraductal papillary mucinous neoplasm (IPMN) of the pancreas remains characterized by notable challenges with regard to diagnosis and treatment. Owing to its heterogeneous biological behavior, which can range from benign lesions to invasive carcinomas, IPMN represents a marked clinical challenge in management. Biopsy in addition to endoscopic retrograde cholangiopancreatography (ERCP) using eyeMAX can aid in the development of an individualized treatment plan. The present report outlines the case of a patient with suspected IPMN who was admitted to Shandong Provincial Hospital Affiliated to Shandong First Medical University (Jinan, China). Endoscopic ultrasound examination revealed a dilated main pancreatic duct (MPD). The duodenal papilla showed signs of a fish mouth covered with mucus through observation by a duodenoscope. The patient refused the surgical treatment due to concerns regarding the risks of surgery. Subsequently, aided by ERCP using eyeMAX, the villus-like and papillary protrusions were visualized intuitively in the MPD wall of the pancreatic head segment. A total of four pieces of tissue were taken from the pancreatic duct for biopsy, with pathology revealing low-grade dysplasia. Furthermore, direct observation revealed that the wall of the body-tail portion of the MPD was smooth. Given that the pathology revealed a low malignant transformation tendency, it was decided that a follow-up strategy would be conducted for the patient. The most recent follow-up occurred in July 2026. The patient was generally in good condition without jaundice, pancreatitis or abdominal pain. Therefore, biopsies based on ERCP using eyeMAX may be helpful in developing individualized treatment plans for patients with IPMNs in the future.
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BibTeX
@article{wang2026combination,
title = {{A combination of biopsy using eyeMAX and ERCP for the definitive diagnosis of intraductal papillary mucinous neoplasm: A case report.}},
author = {Wenwen Wang and Tao Li and Jinhua Hu and Zhou Luan and Yuanzi Yu},
journal = {Experimental and therapeutic medicine},
year = {2026},
month = oct,
doi = {10.3892/etm.2026.13332},
url = {https://europepmc.org/article/MED/42948302},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - A combination of biopsy using eyeMAX and ERCP for the definitive diagnosis of intraductal papillary mucinous neoplasm: A case report.
AU - Wenwen Wang
AU - Tao Li
AU - Jinhua Hu
AU - Zhou Luan
AU - Yuanzi Yu
PY - 2026
DA - 2026/10/09
JO - Experimental and therapeutic medicine
DO - 10.3892/etm.2026.13332
UR - https://europepmc.org/article/MED/42948302
AB - As a well-established precursor lesion of pancreatic cancer, intraductal papillary mucinous neoplasm (IPMN) of the pancreas remains characterized by notable challenges with regard to diagnosis and treatment. Owing to its heterogeneous biological behavior, which can range from benign lesions to invasive carcinomas, IPMN represents a marked clinical challenge in management. Biopsy in addition to endoscopic retrograde cholangiopancreatography (ERCP) using eyeMAX can aid in the development of an individualized treatment plan. The present report outlines the case of a patient with suspected IPMN who was admitted to Shandong Provincial Hospital Affiliated to Shandong First Medical University (Jinan, China). Endoscopic ultrasound examination revealed a dilated main pancreatic duct (MPD). The duodenal papilla showed signs of a fish mouth covered with mucus through observation by a duodenoscope. The patient refused the surgical treatment due to concerns regarding the risks of surgery. Subsequently, aided by ERCP using eyeMAX, the villus-like and papillary protrusions were visualized intuitively in the MPD wall of the pancreatic head segment. A total of four pieces of tissue were taken from the pancreatic duct for biopsy, with pathology revealing low-grade dysplasia. Furthermore, direct observation revealed that the wall of the body-tail portion of the MPD was smooth. Given that the pathology revealed a low malignant transformation tendency, it was decided that a follow-up strategy would be conducted for the patient. The most recent follow-up occurred in July 2026. The patient was generally in good condition without jaundice, pancreatitis or abdominal pain. Therefore, biopsies based on ERCP using eyeMAX may be helpful in developing individualized treatment plans for patients with IPMNs in the future.
SN - 1792-0981
SN - 1792-1015
ER -