Long-range linkage maintained male-specific loci on a young Y chromosome prior to recombination shutdown
- 1University of British Columbia
Abstract
Suppression of recombination on the Y chromosome maintains linkage between male-specific loci and is commonly established by inversions. Here, we describe a young, inversion-free Y chromosome (neo-Y) in Drosophila albomicans with a unique history and paradoxical signature of exchange. Prior to recombination shutdown in males, it repeatedly recombined with the X-linked counterpart (neo-X) but at the same time preserved complete long-range linkage of the chromosome ends. By assembling multiple neo-Ys chromosomes and QTL-mapping, we show that double crossovers maintained linkage between the male-sex determining region at one end to sexually antagonistic alleles and a locus essential for spermatogenesis at the other. We argue that such long-range linkage of distal sex-specific loci disfavors inversions but instead encourages the emergence of achiasmy.
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BibTeX
@misc{wang2026longrange,
title = {{Long-range linkage maintained male-specific loci on a young Y chromosome prior to recombination shutdown}},
author = {M. Wang and M. Akhavizadegan and J.-Y. Wang and C.-H. Chang and K. H.-C. Wei},
howpublished = {bioRxiv},
year = {2026},
month = aug,
doi = {10.64898/2026.08.31.748364},
url = {https://www.biorxiv.org/content/10.64898/2026.08.31.748364v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Long-range linkage maintained male-specific loci on a young Y chromosome prior to recombination shutdown
AU - M. Wang
AU - M. Akhavizadegan
AU - J.-Y. Wang
AU - C.-H. Chang
AU - K. H.-C. Wei
PY - 2026
DA - 2026/08/31
PB - bioRxiv
DO - 10.64898/2026.08.31.748364
UR - https://www.biorxiv.org/content/10.64898/2026.08.31.748364v1
AB - Suppression of recombination on the Y chromosome maintains linkage between male-specific loci and is commonly established by inversions. Here, we describe a young, inversion-free Y chromosome (neo-Y) in Drosophila albomicans with a unique history and paradoxical signature of exchange. Prior to recombination shutdown in males, it repeatedly recombined with the X-linked counterpart (neo-X) but at the same time preserved complete long-range linkage of the chromosome ends. By assembling multiple neo-Ys chromosomes and QTL-mapping, we show that double crossovers maintained linkage between the male-sex determining region at one end to sexually antagonistic alleles and a locus essential for spermatogenesis at the other. We argue that such long-range linkage of distal sex-specific loci disfavors inversions but instead encourages the emergence of achiasmy.
ER -