PreprintCC BYChemRxiv
A Solution-Gated Graphene Transistor Sensor for the Detection and Quantification of Guanine Quadruplexes.
4 affiliations
- 1Université Paris Cité and CNRS, ITODYS
- 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies Viale delle Scienze
- 3Università degli Studi di Palermo
- 4CRAN UMR
Abstract
SGGT G4 Detection 2 ABSTRACT. We report the design, realization, and testing of a Solution-Gated Graphene Transistor Sensor aimed at detecting and quantifying guanine quadruplexes. By using all-atom molecular dynamic simulations complemented with free energy methods we rationally design the architecture of the sensors, exploiting an economic and easy-available G4 ligand. The prototype of the sensor has shown the capacity to provide a linear response depending on the G4 concentration, hence showing the proof of concept of its applicability for G4 detection. The proposed sensors may allow the rapid detection of guanine quadruplexes in complex matrices, without relying on the use of antibodies or complex experimental apparatus.
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BibTeX
@misc{rainot2026solutiongated,
title = {{A Solution-Gated Graphene Transistor Sensor for the Detection and Quantification of Guanine Quadruplexes.}},
author = {Aurianne Rainot and Dieu Linh Nguyen and Alessio Terenzi and Raphael Rouget and Stéphanie Grandemange and Giampaolo Barone and Florent Barbault and Benoit Piro and Antonio Monari},
howpublished = {ChemRxiv},
year = {2026},
month = oct,
doi = {10.26434/chemrxiv.15010179/v1},
url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010179/v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - A Solution-Gated Graphene Transistor Sensor for the Detection and Quantification of Guanine Quadruplexes.
AU - Aurianne Rainot
AU - Dieu Linh Nguyen
AU - Alessio Terenzi
AU - Raphael Rouget
AU - Stéphanie Grandemange
AU - Giampaolo Barone
AU - Florent Barbault
AU - Benoit Piro
AU - Antonio Monari
PY - 2026
DA - 2026/10/09
PB - ChemRxiv
DO - 10.26434/chemrxiv.15010179/v1
UR - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010179/v1
AB - SGGT G4 Detection 2 ABSTRACT. We report the design, realization, and testing of a Solution-Gated Graphene Transistor Sensor aimed at detecting and quantifying guanine quadruplexes. By using all-atom molecular dynamic simulations complemented with free energy methods we rationally design the architecture of the sensors, exploiting an economic and easy-available G4 ligand. The prototype of the sensor has shown the capacity to provide a linear response depending on the G4 concentration, hence showing the proof of concept of its applicability for G4 detection. The proposed sensors may allow the rapid detection of guanine quadruplexes in complex matrices, without relying on the use of antibodies or complex experimental apparatus.
ER -