Micronized Acellular Dermal Matrix and Synthetic Polymers: Temporal Macrophage Transition as a Mechanistic Framework
4 affiliations
- 1Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea
- 2Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea
- 3Department of Dermatology, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea
- 4Department of Anatomy, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi 100000, Vietnam
Abstract
Injectable biodegradable polymers and micronized acellular dermal matrix (mADM) have potentially complementary regenerative properties, but how their combination shapes the host response remains poorly defined. In many systems, polymers provide persistent material-associated stimulation that may sustain macrophage-driven foreign-body responses, whereas mADM provides tissue-derived extracellular matrix (ECM) cues that support cellular infiltration, vascularization, and remodeling, with persistence dependent on processing and host-mediated replacement. This narrative review evaluates whether changes in macrophage population states could help explain potential polymer–mADM synergy. Across the reviewed polymer–ECM hybrid studies, most evidence is indirect, and temporal sampling rarely resolves sequential state changes. No included study establishes temporal coupling as a causal mechanism. We therefore propose a temporal macrophage-switching model in which both components act from implantation and their relative contributions change over time; their spatiotemporal overlap may shape macrophage population trajectories and remodeling outcomes. We further define a functional macrophage polarization window using biological landmarks rather than fixed time points. The model remains a testable hypothesis whose applicability depends on material and tissue context. Validation requires polymer-only, mADM-only, and hybrid comparisons across independent mADM lots, with systematic variation in polymer persistence, mADM processing, component ratio, spatial organization, and degradation/remodeling kinetics.
Related
- Ultra-fine Micronized Human Acellular Dermal Matrix Promotes Diabetic Wound Healing in a Mouse Model
- Mechanistic insights into TLR2-mediated acute pancreatitis exacerbation via macrophage-ferroptotic acinar cell crosstalk
- The role and mechanism of macrophage-to-myofibroblast transition in fibrotic diseases
- Transition metal dyshomeostasis-associated macrophage dysfunction: potential roles in chronic metabolic diseases
- The lipotoxicity–ferroptosis axis in the transition from insulin resistance to type 2 diabetes: mechanistic integration and therapeutic opportunities
BibTeX
@article{jin2026micronized,
title = {{Micronized Acellular Dermal Matrix and Synthetic Polymers: Temporal Macrophage Transition as a Mechanistic Framework}},
author = {Zhenyi Jin and Caijun Jin and Zhiyuan Ding and Dang Truong Hai and Huizhen Ming and Suk Bae Seo and Moon-Seop Choi and Jung Hee Shim and Vo Tien Huy and Pham Ngoc Chien and Chan Yeong Heo},
journal = {International Journal of Molecular Sciences},
year = {2026},
month = oct,
doi = {10.3390/ijms27209239},
url = {https://www.mdpi.com/1422-0067/27/20/9239},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Micronized Acellular Dermal Matrix and Synthetic Polymers: Temporal Macrophage Transition as a Mechanistic Framework
AU - Zhenyi Jin
AU - Caijun Jin
AU - Zhiyuan Ding
AU - Dang Truong Hai
AU - Huizhen Ming
AU - Suk Bae Seo
AU - Moon-Seop Choi
AU - Jung Hee Shim
AU - Vo Tien Huy
AU - Pham Ngoc Chien
AU - Chan Yeong Heo
PY - 2026
DA - 2026/10/01
JO - International Journal of Molecular Sciences
DO - 10.3390/ijms27209239
UR - https://www.mdpi.com/1422-0067/27/20/9239
AB - Injectable biodegradable polymers and micronized acellular dermal matrix (mADM) have potentially complementary regenerative properties, but how their combination shapes the host response remains poorly defined. In many systems, polymers provide persistent material-associated stimulation that may sustain macrophage-driven foreign-body responses, whereas mADM provides tissue-derived extracellular matrix (ECM) cues that support cellular infiltration, vascularization, and remodeling, with persistence dependent on processing and host-mediated replacement. This narrative review evaluates whether changes in macrophage population states could help explain potential polymer–mADM synergy. Across the reviewed polymer–ECM hybrid studies, most evidence is indirect, and temporal sampling rarely resolves sequential state changes. No included study establishes temporal coupling as a causal mechanism. We therefore propose a temporal macrophage-switching model in which both components act from implantation and their relative contributions change over time; their spatiotemporal overlap may shape macrophage population trajectories and remodeling outcomes. We further define a functional macrophage polarization window using biological landmarks rather than fixed time points. The model remains a testable hypothesis whose applicability depends on material and tissue context. Validation requires polymer-only, mADM-only, and hybrid comparisons across independent mADM lots, with systematic variation in polymer persistence, mADM processing, component ratio, spatial organization, and degradation/remodeling kinetics.
SN - 1422-0067
ER -