Enantiopure Telluronium Complexes through Bidentate Chalcogen Bonding: From Solid and in Solution Studies to Chiral Recognition
Abstract
This work demonstrates that tetravalent telluronium salts constitute versatile chalcogen bonding (ChB) receptors for polydentate phosphine oxide ligands. A range of bidentate phosphine oxides form highly stable 1:1 complexes with telluronium salt 1BArF in solution. Multinuclear NMR spectroscopy revealed that bidentate coordination occurs through simultaneous interaction of the two phosphine oxide groups with the telluronium centre, while variable-temperature experiments evidenced a dynamic ligand-exchange process involving the third accessible σ-hole. The formation of the enantiopure telluronium complex with (S)-BINAPO was further confirmed by ECD spectroscopy and X-ray diffraction, which highlighted the bidendate coordination mode while preserving one available σ-hole capable of binding an external Lewis base. Exploiting this remaining ChB donor site, host-guest complexes were formed with DMSO and a series of racemic chiral substrates. The resulting diastereomeric adducts produced clear NMR signal splitting, demonstrating the ability of these chiral telluronium complexes to discriminate between enantiomers through ChB.
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BibTeX
@misc{loicgroslambert2026enantiopure,
title = {{Enantiopure Telluronium Complexes through Bidentate Chalcogen Bonding: From Solid and in Solution Studies to Chiral Recognition}},
author = {Loïc Groslambert,† and Andres Padilla and Avantika Hasija and Jean-Pierre Djukic and Patrick Pale and Emmanuel Aubert and Victor Mamane},
howpublished = {ChemRxiv},
year = {2026},
month = oct,
doi = {10.26434/chemrxiv.15010584/v1},
url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010584/v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - Enantiopure Telluronium Complexes through Bidentate Chalcogen Bonding: From Solid and in Solution Studies to Chiral Recognition
AU - Loïc Groslambert,†
AU - Andres Padilla
AU - Avantika Hasija
AU - Jean-Pierre Djukic
AU - Patrick Pale
AU - Emmanuel Aubert
AU - Victor Mamane
PY - 2026
DA - 2026/10/16
PB - ChemRxiv
DO - 10.26434/chemrxiv.15010584/v1
UR - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010584/v1
AB - This work demonstrates that tetravalent telluronium salts constitute versatile chalcogen bonding (ChB) receptors for polydentate phosphine oxide ligands. A range of bidentate phosphine oxides form highly stable 1:1 complexes with telluronium salt 1BArF in solution. Multinuclear NMR spectroscopy revealed that bidentate coordination occurs through simultaneous interaction of the two phosphine oxide groups with the telluronium centre, while variable-temperature experiments evidenced a dynamic ligand-exchange process involving the third accessible σ-hole. The formation of the enantiopure telluronium complex with (S)-BINAPO was further confirmed by ECD spectroscopy and X-ray diffraction, which highlighted the bidendate coordination mode while preserving one available σ-hole capable of binding an external Lewis base. Exploiting this remaining ChB donor site, host-guest complexes were formed with DMSO and a series of racemic chiral substrates. The resulting diastereomeric adducts produced clear NMR signal splitting, demonstrating the ability of these chiral telluronium complexes to discriminate between enantiomers through ChB.
ER -