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Peer-reviewedCC BY 4.0Nutrients

The Effect of Fibre-Rich Gluten Free Products on Glycaemic Regulation, Gut Symptoms, and Targeted Gut Microbial Taxa in Women with Coeliac Disease: A Randomised Controlled Trial

  • Solveig I. N. Watters1
  • Mari C. W. Myhrstad1
  • Elisabeth Austad1
  • Line Gaundal1
  • Henrik M. Roager2
  • Terje F. Gjøvaag3
  • Monica J. Hellmann4
  • Lisa Garnweidner-Holme1
  • Lise Friis Pedersen5
  • Knut E. A. Lundin6,7
  • Christine Henriksen8
  • Vibeke H. Telle-Hansen1
8 affiliations
  1. 1Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, St. Olavs Plass, P.O. Box 4, 0130 Oslo, Norway
  2. 2Department of Nutrition, Exercise and Sports, University of Copenhagen, Rolighedvej 26, 1958 Frederiksberg, Denmark
  3. 3Department of Rehabilitation Science and Health Technology, Faculty of Health Sciences, Oslo Metropolitan University, 0130 Oslo, Norway
  4. 4Det Glutenfrie Verksted, Nordseterveien 26A, 1176 Oslo, Norway
  5. 5Norwegian Coeliac Society, 0158 Oslo, Norway
  6. 6Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Blindern, P.O. Box 1171, 0318 Oslo, Norway
  7. 7Department of Gastroenterology, Oslo University Hospital, Rikshospitalet, 0424 Oslo, Norway
  8. 8Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Blindern, P.O. Box 1072, 0317 Oslo, Norway
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Abstract

Background: The only treatment for coeliac disease (CeD) is a gluten-free diet. Gluten-containing cereals constitute a major source of dietary fibre, raising concerns about fibre intake for individuals with CeD. Objective: The present study aimed to investigate the effect of pseudocereal-based, fibre-rich gluten-free products on glycaemic regulation in women with CeD. Secondary endpoints were changes in gut symptoms, targeted gut microbial taxa, and inflammatory and metabolic markers. Methods: This double-blind, randomised, controlled trial was conducted remotely and included 30 women with CeD. Participants were allocated to consume either pseudocereal-based, fibre-rich gluten-free products (experimental) or benchmark products (control) for three weeks. Before and after the interventions, participants underwent an oral glucose tolerance test (OGTT), reported gastrointestinal symptoms, and provided blood samples to analyse micronutrients, metabolic markers, and a satiety hormone, and faecal samples for targeted gut microbial taxa analyses. Results: There was no significant difference in the glycaemic response after the intake of fibre-rich products compared with control products. However, a significant reduction in glucose iAUC was observed within the experimental group (p = 0.049). There was no significant change in gut symptoms within or between groups, except for a reduction in diarrhoea in the control group compared with the experimental group. The abundance of five bacterial species was significantly decreased after intake of control products compared to experimental products. Conclusions: Pseudocereal-based, fibre-rich gluten-free products may be included in the diet for women with CeD without affecting gastrointestinal symptoms. Whether these fibre-rich products improve glycaemic regulation and exert effects via alterations in the gut microbiota needs to be further investigated.

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Cite

BibTeXRIS
BibTeX
@article{watters2026effect,
  title = {{The Effect of Fibre-Rich Gluten Free Products on Glycaemic Regulation, Gut Symptoms, and Targeted Gut Microbial Taxa in Women with Coeliac Disease: A Randomised Controlled Trial}},
  author = {Solveig I. N. Watters and Mari C. W. Myhrstad and Elisabeth Austad and Line Gaundal and Henrik M. Roager and Terje F. Gjøvaag and Monica J. Hellmann and Lisa Garnweidner-Holme and Lise Friis Pedersen and Knut E. A. Lundin and Christine Henriksen and Vibeke H. Telle-Hansen},
  journal = {Nutrients},
  year = {2026},
  month = oct,
  doi = {10.3390/nu18213462},
  url = {https://www.mdpi.com/2072-6643/18/21/3462},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - The Effect of Fibre-Rich Gluten Free Products on Glycaemic Regulation, Gut Symptoms, and Targeted Gut Microbial Taxa in Women with Coeliac Disease: A Randomised Controlled Trial
AU  - Solveig I. N. Watters
AU  - Mari C. W. Myhrstad
AU  - Elisabeth Austad
AU  - Line Gaundal
AU  - Henrik M. Roager
AU  - Terje F. Gjøvaag
AU  - Monica J. Hellmann
AU  - Lisa Garnweidner-Holme
AU  - Lise Friis Pedersen
AU  - Knut E. A. Lundin
AU  - Christine Henriksen
AU  - Vibeke H. Telle-Hansen
PY  - 2026
DA  - 2026/10/22
JO  - Nutrients
DO  - 10.3390/nu18213462
UR  - https://www.mdpi.com/2072-6643/18/21/3462
AB  - Background: The only treatment for coeliac disease (CeD) is a gluten-free diet. Gluten-containing cereals constitute a major source of dietary fibre, raising concerns about fibre intake for individuals with CeD. Objective: The present study aimed to investigate the effect of pseudocereal-based, fibre-rich gluten-free products on glycaemic regulation in women with CeD. Secondary endpoints were changes in gut symptoms, targeted gut microbial taxa, and inflammatory and metabolic markers. Methods: This double-blind, randomised, controlled trial was conducted remotely and included 30 women with CeD. Participants were allocated to consume either pseudocereal-based, fibre-rich gluten-free products (experimental) or benchmark products (control) for three weeks. Before and after the interventions, participants underwent an oral glucose tolerance test (OGTT), reported gastrointestinal symptoms, and provided blood samples to analyse micronutrients, metabolic markers, and a satiety hormone, and faecal samples for targeted gut microbial taxa analyses. Results: There was no significant difference in the glycaemic response after the intake of fibre-rich products compared with control products. However, a significant reduction in glucose iAUC was observed within the experimental group (p = 0.049). There was no significant change in gut symptoms within or between groups, except for a reduction in diarrhoea in the control group compared with the experimental group. The abundance of five bacterial species was significantly decreased after intake of control products compared to experimental products. Conclusions: Pseudocereal-based, fibre-rich gluten-free products may be included in the diet for women with CeD without affecting gastrointestinal symptoms. Whether these fibre-rich products improve glycaemic regulation and exert effects via alterations in the gut microbiota needs to be further investigated.
SN  - 2072-6643
ER  -