Anthelmintic resistance of gastrointestinal nematodes in cattle herds in mid-mountain central France
Abstract
Anthelmintic resistance (AR) in gastrointestinal nematodes is insufficiently studied in cattle in many European regions, including France, where only three studies have been conducted in the north-west. This study evaluated the efficacy of benzimidazoles and avermectins in cattle from a mid-mountain region in central France. Faecal egg count reduction tests (FECRT) were performed in 22 groups of 10–25 calves from 16 dairy or beef farms. Each group received either oral oxfendazole (OFZ, 11 groups) or injectable ivermectin (IVM, 11 groups). Faecal samples were collected in a paired study design before (D 0 ) and after treatment (D 10-14 for OFZ, D 14-17 for IVM). Individual faecal egg counts (FECs) were determined using the Mini-FLOTAC method, and pooled faecal samples were cultured per group to determine the proportions of Ostertagia and Cooperia larvae using droplet digital PCR. Efficacy classification (resistant, susceptible or inconclusive) was determined for each group according to the WAAVP guidelines, using the fecrt.com web application and the clinical protocol scenario with a grey zone of 90–99%. IVM resistance was detected on 10 of 11 farms, with 33–49% and 51–67% of larvae being Ostertagia and Cooperia after treatment, respectively. The remaining farm had inconclusive results. OFZ resistance was detected on 2 of 11 farms, with 100% and 97% of larvae being Ostertagia after treatment. The remaining 9 farms were classified as susceptible. This study provides valuable local insights into AR, which could help raise awareness among farmers and veterinarians and encourage changes in treatment practices.
Related
- Resistance breaking Root-knot nematodes carry a fitness cost associated with defective feeding site development
- Genome‐Wide Analysis of Resistance to Gastrointestinal Parasites in Portuguese Merino and Merino‐Related Sheep
- All screens lead to polo-like kinase 1: A central node in cancer therapeutics and resistance
- Screening Central Asian Wheat Germplasm for Powdery Mildew Resistance and Molecular Characterization of Disease Resistance Genes.
- Anthelmintic effects of forage chicory (Cichorium intybus) against free-living and parasitic stages of Cooperia oncophora
BibTeX
@article{dravigney2026anthelmintic,
title = {{Anthelmintic resistance of gastrointestinal nematodes in cattle herds in mid-mountain central France}},
author = {Laurent Dravigney and Christophe Chartier and Pierre Grelaud and Thibault Jozan and Lisa Ledieu and Mickaël Lopez and Johan Höglund and Nadine Ravinet},
journal = {Journal of Helminthology},
year = {2026},
month = jun,
doi = {10.1017/s0022149x26101746},
url = {https://hal.inrae.fr/hal-05725929v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Anthelmintic resistance of gastrointestinal nematodes in cattle herds in mid-mountain central France
AU - Laurent Dravigney
AU - Christophe Chartier
AU - Pierre Grelaud
AU - Thibault Jozan
AU - Lisa Ledieu
AU - Mickaël Lopez
AU - Johan Höglund
AU - Nadine Ravinet
PY - 2026
DA - 2026/06/26
JO - Journal of Helminthology
DO - 10.1017/s0022149x26101746
UR - https://hal.inrae.fr/hal-05725929v1
AB - Anthelmintic resistance (AR) in gastrointestinal nematodes is insufficiently studied in cattle in many European regions, including France, where only three studies have been conducted in the north-west. This study evaluated the efficacy of benzimidazoles and avermectins in cattle from a mid-mountain region in central France. Faecal egg count reduction tests (FECRT) were performed in 22 groups of 10–25 calves from 16 dairy or beef farms. Each group received either oral oxfendazole (OFZ, 11 groups) or injectable ivermectin (IVM, 11 groups). Faecal samples were collected in a paired study design before (D 0 ) and after treatment (D 10-14 for OFZ, D 14-17 for IVM). Individual faecal egg counts (FECs) were determined using the Mini-FLOTAC method, and pooled faecal samples were cultured per group to determine the proportions of Ostertagia and Cooperia larvae using droplet digital PCR. Efficacy classification (resistant, susceptible or inconclusive) was determined for each group according to the WAAVP guidelines, using the fecrt.com web application and the clinical protocol scenario with a grey zone of 90–99%. IVM resistance was detected on 10 of 11 farms, with 33–49% and 51–67% of larvae being Ostertagia and Cooperia after treatment, respectively. The remaining farm had inconclusive results. OFZ resistance was detected on 2 of 11 farms, with 100% and 97% of larvae being Ostertagia after treatment. The remaining 9 farms were classified as susceptible. This study provides valuable local insights into AR, which could help raise awareness among farmers and veterinarians and encourage changes in treatment practices.
SN - 0022-149X
SN - 1475-2697
ER -