Skip to content
DraconiticResearch
Search Sources API
181,716 studies31 sourcesUpdated 50 min ago
Peer-reviewedCC BYBMC Cardiovascular Disorders

Association between the triglyceride-glucose index and carotid-femoral pulse wave velocity in rural hypertensive adults

  • Zaihua Cheng1
  • Lan Gao2
  • Xudong Hu1
  • Wanjin Guan3
  • Tianyu Cao3
  • Lishun Liu4
  • Yan Zhang2
  • Jianping Li2
  • Yong Huo2
  • Xiaoshu Cheng1
  • Hong Wang5
  • Xiao Huang1
5 affiliations
  1. 1Department of Cardiology, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University
  2. 2Department of Cardiology, Peking University First Hospital
  3. 3Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
  4. 4Shenzhen Evergreen Medical Institute
  5. 5Temple University Lewis Katz School of Medicine
Read full textDOICite

Abstract

Background Triglyceride-glucose (TyG) index is a surrogate marker of insulin resistance and has been linked with cardiovascular outcomes. However, its association with arterial stiffness is understudied, particularly among hypertensive adults. Objectives To explore the association between TyG index and arterial stiffness, assessed by carotid-femoral pulse wave velocity (cfPWV), among a group of rural dwelling hypertensive adults. Methods A total of 12,751 hypertensive participants from the Hypertension and Stroke Prevention and Control Project (HSPCP) were analyzed. cfPWV was measured noninvasively using a PulsePen device (WPP001-ET, DiaTecne s.r.l.). TyG index was calculated as ln [fasting triglycerides (mg/dL) ×fasting glucose (mg/dL)/2]. Multivariate linear regression and log-binomial regression were used to explore the cross-sectional association between TyG index and cfPWV. Subgroup analyses were applied to identify potential effect modifiers. Results The mean age was 59.8 years, with 37.3% being male. The mean TyG index was 8.9 (SD, 0.7), and the mean cfPWV was 9.3 m/s. In the multivariable-adjusted model, a higher TyG index was associated higher cfPWV (β = 0.15 [95% CI: 0.10–0.21]). When analyzed as quartiles, participants in the highest quartile of the TyG index (≥ 9.2) had the highest level of cfPWV (β = 0.28 [95% CI 0.17–0.38]; ref=lowest quartile), and was dose-dependent. Additionally, each unit increase in the TyG index was associated with a 12% increased risk of elevated cfPWV. Participants in the highest TyG index quartile had a 26% greater likelihood of having cfPWV > 10 m/s compared to those in the lowest quartile. In sensitivity analysis, adjusting for fasting glucose reduced but did not eliminate the association (β = 0.07 [95% CI: 0.03–0.11]). Each unit increase in the TyG index was linked to a 7% higher prevalence of elevated cfPWV after adjusting for fasting glucose (RR = 1.07 [95% CI: 1.04–1.11]). Subgroup analysis indicated a stronger association in non-obese participants, though this should be interpreted with caution. Conclusion The TyG index was positively associated with measured cfPWV among rural hypertensive adults in cross-sectional analyses. These findings suggest that the TyG index may be related to subclinical central arterial stiffness in this population.

Related

  1. The association of triglyceride-glucose body roundness index with carotid atherosclerosis in type 2 diabetes: a cross-sectional study
    Cuihua Huang, Yan Tong, Yan Luo +1
    Frontiers in endocrinologyPeer-reviewedCC BYFull textEndocrinology & metabolismEurope PMCCrossref
  2. Visit-to-visit variability and longitudinal change of the triglyceride-glucose index are associated with early carotid plaque progression.
    Pan Tang, Min Cui, Ru Li +2
    BMC cardiovascular disordersPeer-reviewedCC BY-NC-NDFull textEndocrinology & metabolismEurope PMCDOAJ
  3. Association of the triglyceride-glucose index and triglyceride-glucose-body mass index with postoperative atrial fibrillation in patients undergoing off-pump coronary artery bypass grafting: a retrospective cohort study
    Zhiyuan Song, Jiawei Wu, Ze Bu +6
    Journal of thoracic diseasePeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC
  4. Association of triglyceride-glucose and its related indices with circadian syndrome : Evidence from a prospective cohort study
    MedicinePeer-reviewedCC BY-NCFull textGeneral medicineEurope PMC
  5. Association between triglyceride glucose–relative fat mass index and obstructive sleep apnea risk : A cross-sectional study from NHANES
    Yunzhou Zheng, Shanshan Zhang, Mingqiang Mi
    MedicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{cheng2026association,
  title = {{Association between the triglyceride-glucose index and carotid-femoral pulse wave velocity in rural hypertensive adults}},
  author = {Zaihua Cheng and Lan Gao and Xudong Hu and Wanjin Guan and Tianyu Cao and Lishun Liu and Yan Zhang and Jianping Li and Yong Huo and Xiaoshu Cheng and Hong Wang and Xiao Huang},
  journal = {BMC Cardiovascular Disorders},
  year = {2026},
  month = jul,
  doi = {10.1186/s12872-026-06327-1},
  url = {https://doi.org/10.1186/s12872-026-06327-1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Association between the triglyceride-glucose index and carotid-femoral pulse wave velocity in rural hypertensive adults
AU  - Zaihua Cheng
AU  - Lan Gao
AU  - Xudong Hu
AU  - Wanjin Guan
AU  - Tianyu Cao
AU  - Lishun Liu
AU  - Yan Zhang
AU  - Jianping Li
AU  - Yong Huo
AU  - Xiaoshu Cheng
AU  - Hong Wang
AU  - Xiao Huang
PY  - 2026
DA  - 2026/07/01
JO  - BMC Cardiovascular Disorders
DO  - 10.1186/s12872-026-06327-1
UR  - https://doi.org/10.1186/s12872-026-06327-1
AB  - Background Triglyceride-glucose (TyG) index is a surrogate marker of insulin resistance and has been linked with cardiovascular outcomes. However, its association with arterial stiffness is understudied, particularly among hypertensive adults. Objectives To explore the association between TyG index and arterial stiffness, assessed by carotid-femoral pulse wave velocity (cfPWV), among a group of rural dwelling hypertensive adults. Methods A total of 12,751 hypertensive participants from the Hypertension and Stroke Prevention and Control Project (HSPCP) were analyzed. cfPWV was measured noninvasively using a PulsePen device (WPP001-ET, DiaTecne s.r.l.). TyG index was calculated as ln [fasting triglycerides (mg/dL) ×fasting glucose (mg/dL)/2]. Multivariate linear regression and log-binomial regression were used to explore the cross-sectional association between TyG index and cfPWV. Subgroup analyses were applied to identify potential effect modifiers. Results The mean age was 59.8 years, with 37.3% being male. The mean TyG index was 8.9 (SD, 0.7), and the mean cfPWV was 9.3 m/s. In the multivariable-adjusted model, a higher TyG index was associated higher cfPWV (β = 0.15 [95% CI: 0.10–0.21]). When analyzed as quartiles, participants in the highest quartile of the TyG index (≥ 9.2) had the highest level of cfPWV (β = 0.28 [95% CI 0.17–0.38]; ref=lowest quartile), and was dose-dependent. Additionally, each unit increase in the TyG index was associated with a 12% increased risk of elevated cfPWV. Participants in the highest TyG index quartile had a 26% greater likelihood of having cfPWV > 10 m/s compared to those in the lowest quartile. In sensitivity analysis, adjusting for fasting glucose reduced but did not eliminate the association (β = 0.07 [95% CI: 0.03–0.11]). Each unit increase in the TyG index was linked to a 7% higher prevalence of elevated cfPWV after adjusting for fasting glucose (RR = 1.07 [95% CI: 1.04–1.11]). Subgroup analysis indicated a stronger association in non-obese participants, though this should be interpreted with caution. Conclusion The TyG index was positively associated with measured cfPWV among rural hypertensive adults in cross-sectional analyses. These findings suggest that the TyG index may be related to subclinical central arterial stiffness in this population.
SN  - 1471-2261
ER  -