Skip to content
DraconiticResearch
Search Sources API
203,203 studies31 sourcesUpdated 51 min ago
Peer-reviewedCC BY-NC-NDAmerican Heart Journal Plus

Progression rates of aortic stenosis in patients with calcific and rheumatic heart disease in Saudi Arabia

  • Zeinelabdien T. Elsherif
  • Dania Elsherif1
  • Amjad M. Ahmed2
  • Husam I. Ardah3
  • Fawaz Al-Mutairi2
  • Safeah Almaghrabi4
  • Futun Alanazi4
  • Hind Alaqeel5
  • Mashael Almohaimeed6
  • Rana Alklaib4
  • Jawza Aldakhil7
  • Haifa Alturki4
7 affiliations
  1. 1Independent researcher, Riyadh, Saudi Arabia
  2. 2King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia; King Abdulaziz Cardiac Center, King Abdulaziz Medical City, Riyadh, Saudi Arabia
  3. 3King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Department of Biostatistics and bioinformatics, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia
  4. 4Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia; King Abdulaziz Cardiac Center, King Abdulaziz Medical City, Riyadh, Saudi Arabia
  5. 5Sultan Bin Abdulaziz Humanitarian City, Riyadh, Saudi Arabia
  6. 6MSc Digital Health and Entrepreneurship, University College London, Prince Sultan Cardiac Center, Riyadh, Saudi Arabia
  7. 7King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
Read full textPDFDOICite

Abstract

Study objective: Calcific aortic stenosis (AS) is the most prevalent type of AS in developed countries. However, in developing countries, rheumatic heart disease (RHD), which has a low progression rate, remains the prevalent type. This study compared the progression rates of AS between the National Guard cohort and Western populations. Design: This was a retrospective single-center cohort study. Participants: Involving patients who underwent two echocardiographic examinations within an interval of at least 2 years. Main outcome measures: Progression of aortic valve stenosis was assessed by measuring changes in the aortic valve area (AVA), peak aortic velocity, and mean aortic valve gradient. Results: In total, 1669 patients (median follow-up: 6.9 years) were included in the analysis. The overall annual AVA progression rate was 0.074 ± 0.1 cm 2 /year (median: −0.061 cm 2 /year). Patients with RHD had lower progression rates than those without RHD (25%–35%; AVA: −0.036 [−0.042, −0.030] cm 2 /year). Patients with end-stage renal disease (ESRD) who exhibited calcific AS had the highest progression rate (AVA: −0.102 ± 0.096 cm 2 /year). The overall progression rate of AS for the National Guard cohort was lower across all groups compared with that in Western populations (AVA: −0.08 to 0.12 cm 2 /year). Conclusions: Patients with ESRD who had calcific AS had the highest progression rate. Meanwhile, patients with RHD exhibited the lowest progression rate. The high prevalence of calcific AS in our study shows the importance of adherence to the American College of Cardiology/European Society of Cardiology guidelines for disease management.

Related

  1. Altered kynurenine and indole tryptophan pathways in calcific aortic stenosis: cross-sectional evidence for a gut-host metabolic imbalance (GUT-CAS)
    C. Chong-Nguyen, S. Atighetchi, C. Ferro +18
    medRxivPreprintAll rights reservedFull textCardiovascular medicinemedRxiv
  2. Understanding what retains patients in rheumatic heart disease care: a qualitative study of an integrated control program in northern Uganda
    Jafesi Pulle, Isaac O. Otim, Michaela Pardo +9
    BMC Public HealthPeer-reviewedCC BY-NC-ND 4.0Epidemiology & public healthCrossref
  3. Lipoprotein(a) in calcific aortic stenosis: mechanistic insights, clinical evidence, and emerging therapies
    Wang Li, Shao Yun Shuang, You Bei An +5
    Frontiers in Cardiovascular MedicinePeer-reviewedCC BY 4.0Full textCardiovascular medicineCrossrefPMC
  4. Foundation Model Artificial Intelligence for Electrocardiogram Detection of Rheumatic Mitral Stenosis
    R. Sriram, I. Nenadic, Z. Loring +4
    medRxivPreprintCC BYFull textCardiovascular medicinemedRxiv
  5. Sirtuin 1 modulation unlocks the therapeutic potential of sodium-glucose co-transporter 2 inhibitors (SGLT2i) in calcific aortic valve stenosis
    Vincenza Valerio, Ilaria Massaiu, Matteo Franchi +16
    Cardiovascular ResearchPeer-reviewedCC BY1 citedCardiovascular medicineHAL

Cite

BibTeXRIS
BibTeX
@article{elsherif2026progression,
  title = {{Progression rates of aortic stenosis in patients with calcific and rheumatic heart disease in Saudi Arabia}},
  author = {Zeinelabdien T. Elsherif and Dania Elsherif and Amjad M. Ahmed and Husam I. Ardah and Fawaz Al-Mutairi and Safeah Almaghrabi and Futun Alanazi and Hind Alaqeel and Mashael Almohaimeed and Rana Alklaib and Jawza Aldakhil and Haifa Alturki},
  journal = {American Heart Journal Plus},
  year = {2026},
  month = oct,
  doi = {10.1016/j.ahjo.2026.100976},
  url = {https://doi.org/10.1016/j.ahjo.2026.100976},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Progression rates of aortic stenosis in patients with calcific and rheumatic heart disease in Saudi Arabia
AU  - Zeinelabdien T. Elsherif
AU  - Dania Elsherif
AU  - Amjad M. Ahmed
AU  - Husam I. Ardah
AU  - Fawaz Al-Mutairi
AU  - Safeah Almaghrabi
AU  - Futun Alanazi
AU  - Hind Alaqeel
AU  - Mashael Almohaimeed
AU  - Rana Alklaib
AU  - Jawza Aldakhil
AU  - Haifa Alturki
PY  - 2026
DA  - 2026/10/20
JO  - American Heart Journal Plus
DO  - 10.1016/j.ahjo.2026.100976
UR  - https://doi.org/10.1016/j.ahjo.2026.100976
AB  - Study objective: Calcific aortic stenosis (AS) is the most prevalent type of AS in developed countries. However, in developing countries, rheumatic heart disease (RHD), which has a low progression rate, remains the prevalent type. This study compared the progression rates of AS between the National Guard cohort and Western populations. Design: This was a retrospective single-center cohort study. Participants: Involving patients who underwent two echocardiographic examinations within an interval of at least 2 years. Main outcome measures: Progression of aortic valve stenosis was assessed by measuring changes in the aortic valve area (AVA), peak aortic velocity, and mean aortic valve gradient. Results: In total, 1669 patients (median follow-up: 6.9 years) were included in the analysis. The overall annual AVA progression rate was 0.074 ± 0.1 cm 2 /year (median: −0.061 cm 2 /year). Patients with RHD had lower progression rates than those without RHD (25%–35%; AVA: −0.036 [−0.042, −0.030] cm 2 /year). Patients with end-stage renal disease (ESRD) who exhibited calcific AS had the highest progression rate (AVA: −0.102 ± 0.096 cm 2 /year). The overall progression rate of AS for the National Guard cohort was lower across all groups compared with that in Western populations (AVA: −0.08 to 0.12 cm 2 /year). Conclusions: Patients with ESRD who had calcific AS had the highest progression rate. Meanwhile, patients with RHD exhibited the lowest progression rate. The high prevalence of calcific AS in our study shows the importance of adherence to the American College of Cardiology/European Society of Cardiology guidelines for disease management.
SN  - 2666-6022
ER  -