Development of Marine-Lenhart Syndrome during the Course of Acromegaly
Abstract
A 76-year-old woman was diagnosed with acromegaly and underwent resection of a transsphenoidal pituitary tumor. Central hypothyroidism was detected before surgery and the patient was treated with levothyroxine. Insulin-like growth factor-1 (IGF-1) levels remained abnormal after surgery. Follow-up showed an increase in free thyroxine levels even after discontinuation of levothyroxine; thereafter, Marine-Lenhart syndrome was diagnosed. The initiation of treatment with a somatostatin analog for acromegaly and thiamazole for Marine-Lenhart syndrome was followed by normalization of IGF-1 levels and thyroid function test results. Coexistent thyrotoxicosis is rare in patients with acromegaly; therefore, attention should be paid to elderly patients, as they exhibit only a few symptoms.
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BibTeX
@article{saito2026development,
title = {{Development of Marine-Lenhart Syndrome during the Course of Acromegaly}},
author = {Momo Saito and Yosuke Okada and Fumi Uemura and Yoshiya Tanaka},
journal = {Internal Medicine},
year = {2026},
month = aug,
doi = {10.2169/internalmedicine.5550-25},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_5550-25/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Development of Marine-Lenhart Syndrome during the Course of Acromegaly
AU - Momo Saito
AU - Yosuke Okada
AU - Fumi Uemura
AU - Yoshiya Tanaka
PY - 2026
DA - 2026/08/01
JO - Internal Medicine
DO - 10.2169/internalmedicine.5550-25
UR - https://www.jstage.jst.go.jp/article/internalmedicine/65/15/65_5550-25/_article
AB - A 76-year-old woman was diagnosed with acromegaly and underwent resection of a transsphenoidal pituitary tumor. Central hypothyroidism was detected before surgery and the patient was treated with levothyroxine. Insulin-like growth factor-1 (IGF-1) levels remained abnormal after surgery. Follow-up showed an increase in free thyroxine levels even after discontinuation of levothyroxine; thereafter, Marine-Lenhart syndrome was diagnosed. The initiation of treatment with a somatostatin analog for acromegaly and thiamazole for Marine-Lenhart syndrome was followed by normalization of IGF-1 levels and thyroid function test results. Coexistent thyrotoxicosis is rare in patients with acromegaly; therefore, attention should be paid to elderly patients, as they exhibit only a few symptoms.
SN - 1349-7235
SN - 0918-2918
ER -