Weight Loss and Long-Term Weight Trajectories After a Structured Nutritional and Behavioral Intervention: A Large Real-World Cohort Study
6 affiliations
- 1Groupe Éthique et Santé, Actiburo 1, Bâtiment A, 100 Chemin de l’Aumône Vieille, 13400 Aubagne, France
- 2HP2 Laboratory, INSERM U1300, Grenoble Alpes University Hospital, University Grenoble Alpes, 38000 Grenoble, France
- 3Department of Human Nutrition, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G31 2ER, UK
- 4Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, 2650 Edegem, Belgium
- 5Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford OX2 6GG, UK
- 6Nutrition Unit, Copenhagen University Hospital—Bispebjerg and Frederiksberg, DK-2400 Copenhagen NV, Denmark
Abstract
Background/Objectives: Achieving and maintaining intentional weight loss is a major challenge in routine clinical practice, and real-world evidence is limited. Methods: This retrospective cohort study evaluated initial weight loss in 56,093 adults from a total of 126,659 who commenced the French RNPC program between 2013 and 2025, and subsequent weight trajectories in 2395 participants with 4-year follow-up data. The intervention combined an energy-restricted, protein-enriched, low-glycemic-load diet with individualized dietary and behavioral support, followed by progressive food reintroduction and optional long-term follow-up. Results: During the weight-loss phase (median, 4.6 months), median body weight decreased by 11.0 kg (12.7%) and waist circumference by 12.0 cm (11.8%), while lean mass percentage increased by 1.3 percentage points. At 4 years, among the 2395 participants with available follow-up data, median weight remained 7.8 kg (9.1%) and waist circumference 10.0 cm (9.8%) below baseline. Longitudinal mixed-effects models using all available repeated measurements showed similar patterns in weight, BMI, waist circumference, fat mass, waist-to-height ratio, and relative fat mass at 4 years. Conclusions: These findings show substantial initial weight loss and long-term maintenance of clinically meaningful reductions in weight and waist circumference among participants with 4-year follow-up data after a structured nutritional and behavioral intervention in routine clinical practice.
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BibTeX
@article{fabre2026weight,
title = {{Weight Loss and Long-Term Weight Trajectories After a Structured Nutritional and Behavioral Intervention: A Large Real-World Cohort Study}},
author = {Odile Fabre and Sébastien Bailly and Laurent Pantagis and Rémy Legrand and Michael E. J. Lean and Luc F. Van Gaal and Susan A. Jebb and Arne Astrup},
journal = {Nutrients},
year = {2026},
month = oct,
doi = {10.3390/nu18203364},
url = {https://www.mdpi.com/2072-6643/18/20/3364},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Weight Loss and Long-Term Weight Trajectories After a Structured Nutritional and Behavioral Intervention: A Large Real-World Cohort Study
AU - Odile Fabre
AU - Sébastien Bailly
AU - Laurent Pantagis
AU - Rémy Legrand
AU - Michael E. J. Lean
AU - Luc F. Van Gaal
AU - Susan A. Jebb
AU - Arne Astrup
PY - 2026
DA - 2026/10/01
JO - Nutrients
DO - 10.3390/nu18203364
UR - https://www.mdpi.com/2072-6643/18/20/3364
AB - Background/Objectives: Achieving and maintaining intentional weight loss is a major challenge in routine clinical practice, and real-world evidence is limited. Methods: This retrospective cohort study evaluated initial weight loss in 56,093 adults from a total of 126,659 who commenced the French RNPC program between 2013 and 2025, and subsequent weight trajectories in 2395 participants with 4-year follow-up data. The intervention combined an energy-restricted, protein-enriched, low-glycemic-load diet with individualized dietary and behavioral support, followed by progressive food reintroduction and optional long-term follow-up. Results: During the weight-loss phase (median, 4.6 months), median body weight decreased by 11.0 kg (12.7%) and waist circumference by 12.0 cm (11.8%), while lean mass percentage increased by 1.3 percentage points. At 4 years, among the 2395 participants with available follow-up data, median weight remained 7.8 kg (9.1%) and waist circumference 10.0 cm (9.8%) below baseline. Longitudinal mixed-effects models using all available repeated measurements showed similar patterns in weight, BMI, waist circumference, fat mass, waist-to-height ratio, and relative fat mass at 4 years. Conclusions: These findings show substantial initial weight loss and long-term maintenance of clinically meaningful reductions in weight and waist circumference among participants with 4-year follow-up data after a structured nutritional and behavioral intervention in routine clinical practice.
SN - 2072-6643
ER -