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Peer-reviewedCC BYEnvironmental science & technology

Expanding the Scope of PFAS Research to Include Adipose Tissues.

  • Xiaodi Shi1
  • Matthew MacLeod1
  • Amila O De Silva2
  • Karl J Jobst3
  • Mélanie Z Lauria1,4
  • Seth R Newton5
  • Jane Prihodova1
  • Anna M Roos6
  • Anne L Soerensen6
  • Elsie M Sunderland7,8
  • Jonathan P Benskin1
  • Satoshi Endo9
9 affiliations
  1. 1Department of Environmental Science, Stockholm University, 10691Stockholm, Sweden.
  2. 2Aquatic Contaminants Research Division, Environment and Climate Change Canada, Burlington, OntarioL7S 1A1, Canada.
  3. 3Department of Chemistry, Memorial University of Newfoundland, St. John's, Newfoundland and LabradorA1C 5S7, Canada.
  4. 4Department of Environmental Chemistry, Eawag, 8600Dübendorf, Switzerland.
  5. 5U.S. Environmental Protection Agency Office of Research and Development, Washington, D.C.20460, United States.
  6. 6Department of Environmental Monitoring and Research, Swedish Museum of Natural History, 10405Stockholm, Sweden.
  7. 7Harvard John A. Paulson School of Engineering & Applied Sciences, Harvard University, Cambridge, Massachusetts02138, United States.
  8. 8Department of Earth and Planetary Sciences, Harvard University, Cambridge, Massachusetts02138, United States.
  9. 9Health and Environmental Risk Division, National Institute for Environmental Studies (NIES), 305-8506Tsukuba, Ibaraki, Japan.
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Abstract

The occurrence and burden of per- and polyfluoroalkyl substances (PFAS) in adipose tissue of humans and wildlife represent an underexamined dimension of PFAS exposure. While most PFAS research has focused on ionic substances that accumulate in tissues such as liver and blood, there is growing evidence that a distinct and diverse suite of neutral PFAS bioaccumulate in adipose tissue. This Perspective synthesizes recent data illustrating the substantial contribution of some adipose-associated PFAS to overall body burdens, applies quantum chemical modeling to exemplify additional PFAS likely to partition into adipose tissue, and examines analytical blindspots that have limited their detection to date. We show that certain neutral PFAS possess partitioning properties comparable to legacy persistent organic pollutants, which, provided that they are sufficiently persistent, can lead to bioaccumulation in adipose tissue. We further outline the analytical challenge of extracting, detecting, and quantifying neutral PFAS in matrices rich in storage lipids and discuss the implications for exposure assessment, toxicology, and environmental surveillance. Finally, we identify key research needs and call for expanded monitoring strategies that capture the full chemical space of PFAS bioaccumulation.

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Cite

BibTeXRIS
BibTeX
@article{shi2026expanding,
  title = {{Expanding the Scope of PFAS Research to Include Adipose Tissues.}},
  author = {Xiaodi Shi and Matthew MacLeod and Amila O De Silva and Karl J Jobst and Mélanie Z Lauria and Seth R Newton and Jane Prihodova and Anna M Roos and Anne L Soerensen and Elsie M Sunderland and Jonathan P Benskin and Satoshi Endo},
  journal = {Environmental science \& technology},
  year = {2026},
  month = sep,
  doi = {10.1021/acs.est.6c01695},
  url = {https://europepmc.org/article/MED/42915420},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Expanding the Scope of PFAS Research to Include Adipose Tissues.
AU  - Xiaodi Shi
AU  - Matthew MacLeod
AU  - Amila O De Silva
AU  - Karl J Jobst
AU  - Mélanie Z Lauria
AU  - Seth R Newton
AU  - Jane Prihodova
AU  - Anna M Roos
AU  - Anne L Soerensen
AU  - Elsie M Sunderland
AU  - Jonathan P Benskin
AU  - Satoshi Endo
PY  - 2026
DA  - 2026/09/01
JO  - Environmental science & technology
DO  - 10.1021/acs.est.6c01695
UR  - https://europepmc.org/article/MED/42915420
AB  - The occurrence and burden of per- and polyfluoroalkyl substances (PFAS) in adipose tissue of humans and wildlife represent an underexamined dimension of PFAS exposure. While most PFAS research has focused on ionic substances that accumulate in tissues such as liver and blood, there is growing evidence that a distinct and diverse suite of neutral PFAS bioaccumulate in adipose tissue. This Perspective synthesizes recent data illustrating the substantial contribution of some adipose-associated PFAS to overall body burdens, applies quantum chemical modeling to exemplify additional PFAS likely to partition into adipose tissue, and examines analytical blindspots that have limited their detection to date. We show that certain neutral PFAS possess partitioning properties comparable to legacy persistent organic pollutants, which, provided that they are sufficiently persistent, can lead to bioaccumulation in adipose tissue. We further outline the analytical challenge of extracting, detecting, and quantifying neutral PFAS in matrices rich in storage lipids and discuss the implications for exposure assessment, toxicology, and environmental surveillance. Finally, we identify key research needs and call for expanded monitoring strategies that capture the full chemical space of PFAS bioaccumulation.
SN  - 0013-936X
SN  - 1520-5851
ER  -